Chandra Measurements of a Complete Sample of X-ray Luminous Galaxy Clusters: The Luminosity-Mass Relation

We present the results of work involving a statistically complete sample of 34 galaxy clusters, in the redshift range 0.15$\le$z$\le$0.3 observed with $Chandra$. We investigate the luminosity-mass ($LM$) relation for the cluster sample, with the masses obtained via a full hydrostatic mass analysis. We utilise a method to fully account for selection biases when modeling the $LM$ relation, and find that the $LM$ relation is significantly different than the relation modelled when not account for selection effects. We find that the luminosity of our clusters is 2.2$\pm$0.4 times higher (when accounting for selection effects) than the average for a given mass, its mass is 30% lower than the population average for a given luminosity. Equivalently, using the $LM$ relation measured from this sample without correcting for selection biases would lead to the underestimation by 40% of the average mass of a cluster with a given luminosity. Comparing the hydrostatic masses to mass estimates determined from the $Y_{X}$ parameter, we find that they are entirely consistent, irrespective of the dynamical state of the cluster.Comment: 31 pages, 43 figures, accepted for publication in MNRA

Soluble urokinase plasminogen activator receptor (suPAR) levels predict damage accrual in patients with recent-onset systemic lupus erythematosus

© 2019 The Authors Objective: The soluble urokinase plasminogen activator receptor (suPAR) has potential as a prognosis and severity biomarker in several inflammatory and infectious diseases. In a previous cross-sectional study, suPAR levels were shown to reflect damage accrual in cases of systemic lupus erythematosus (SLE). Herein, we evaluated suPAR as a predictor of future organ damage in recent-onset SLE. Methods: Included were 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who met the 1997 American College of Rheumatology classification criteria with 5-years of follow-up data available. Baseline sera from patients and age- and sex-matched controls were assayed for suPAR. Organ damage was assessed annually using the SLICC/ACR damage index (SDI). Results: The levels of suPAR were higher in patients who accrued damage, particularly those with SDI≥2 at 5 years (N = 32, 46.8% increase, p = 0.004), as compared to patients without damage. Logistic regression analysis revealed a significant impact of suPAR on SDI outcome (SDI≥2; OR = 1.14; 95% CI 1.03–1.26), also after adjustment for confounding factors. In an optimized logistic regression to predict damage, suPAR persisted as a predictor, together with baseline disease activity (SLEDAI-2K), age, and non-Caucasian ethnicity (model AUC = 0.77). Dissecting SDI into organ systems revealed higher suPAR levels in patients who developed musculoskeletal damage (SDI≥1; p = 0.007). Conclusion: Prognostic biomarkers identify patients who are at risk of acquiring early damage and therefore need careful observation and targeted treatment strategies. Overall, suPAR constitutes an interesting biomarker for patient stratification and for identifying SLE patients who are at risk of acquiring organ damage during the first 5 years of disease

A Thirty Kiloparsec Chain of "Beads on a String" Star Formation Between Two Merging Early Type Galaxies in the Core of a Strong-Lensing Galaxy Cluster

New Hubble Space Telescope ultraviolet and optical imaging of the strong-lensing galaxy cluster SDSS J1531+3414 (z=0.335) reveals two centrally dominant elliptical galaxies participating in an ongoing major merger. The interaction is at least somewhat rich in cool gas, as the merger is associated with a complex network of nineteen massive superclusters of young stars (or small tidal dwarf galaxies) separated by ~1 kpc in projection from one another, combining to an estimated total star formation rate of ~5 solar masses per year. The resolved young stellar superclusters are threaded by narrow H-alpha, [O II], and blue excess filaments arranged in a network spanning ~27 kpc across the two merging galaxies. This morphology is strongly reminiscent of the well-known "beads on a string" mode of star formation observed on kpc-scales in the arms of spiral galaxies, resonance rings, and in tidal tails between interacting galaxies. Nevertheless, the arrangement of this star formation relative to the nuclei of the two galaxies is difficult to interpret in a dynamical sense, as no known "beads on a string" systems associated with kpc-scale tidal interactions exhibit such lopsided morphology relative to the merger participants. In this Letter we present the images and follow-up spectroscopy, and discuss possible physical interpretations for the unique arrangement of the young stellar clusters. While we suggest that this morphology is likely to be dynamically short-lived, a more quantitative understanding awaits necessary multiwavelength follow-up, including optical integral field spectroscopy, ALMA sub-mm interferometry, and Chandra X-ray imaging.Comment: 7 pages, 4 figures, accepted for publication in ApJ Letters. High resolution images of the cluster can be found at http://hubblesite.org/news/2014/2

Weak Gravitational Lensing by a Sample of X-Ray Luminous Clusters of Galaxies -- II. Comparison with Virial Masses

Dynamic velocity dispersion and mass estimates are given for a sample of five X-ray luminous rich clusters of galaxies at intermediate redshifts (z~0.3) drawn from a sample of 39 clusters for which we have obtained gravitational lens mass estimates. The velocity dispersions are determined from between 9 and 20 redshifts measured with the LDSS spectrograph of the William Herschel Telescope, and virial radii are determined from imaging using the UH8K mosaic CCD camera on the University of Hawaii 2.24m telescope. Including clusters with velocity dispersions taken from the literature, we have velocity dispersion estimates for 12 clusters in our gravitational lensing sample. For this sample we compare the dynamical velocity dispersion estimates with our estimates of the velocity dispersions made from gravitational lensing by fitting a singular isothermal sphere profile to the observed tangential weak lensing distortion as a function of radius. In all but two clusters, we find a good agreement between the velocity dispersion estimates based on spectroscopy and on weak lensing.Comment: 9 pages, 4 figures, accepted for publication in ApJ. Version in emulateapj format with only minor change

The Cluster Mass Function from Weak Gravitational Lensing

We present the first measurement of the mass function of galaxy clusters based directly on cluster masses derived from observations of weak gravitational lensing. To investigate the degree of sample incompleteness resulting from the X-ray based selection of the target clusters, we use a sample of 50 clusters with weak lensing mass measurements to empirically determine the relation between lensing mass and X-ray luminosity and the scatter about this relation. We use a complete, volume-limited sub-sample of 35 X-ray luminous clusters of galaxies at 0.15<z<0.3 to constrain the abundance of very massive (M >~ 10^15/h M_sun) clusters. From this, we constrain sigma_8(Omega_m/0.3)^{0.37} = 0.67^{+0.04}_{-0.05} (68% confidence limits), agreeing well with constraints from the 3-year WMAP CMB measurements and estimates of cluster abundances based on X-ray observations, but somewhat lower than constraints from ``cosmic shear'' weak lensing measurements in random fields.Comment: 10 pages, 3 figures. Accepted for publication in Ap

The Shear TEsting Programme 1: Weak lensing analysis of simulated ground-based observations

The Shear TEsting Programme, STEP, is a collaborative project to improve the accuracy and reliability of all weak lensing measurements in preparation for the next generation of wide-field surveys. In this first STEP paper we present the results of a blind analysis of simulated ground-based observations of relatively simple galaxy morphologies. The most successful methods are shown to achieve percent level accuracy. From the cosmic shear pipelines that have been used to constrain cosmology, we find weak lensing shear measured to an accuracy that is within the statistical errors of current weak lensing analyses, with shear measurements accurate to better than 7%. The dominant source of measurement error is shown to arise from calibration uncertainties where the measured shear is over or under-estimated by a constant multiplicative factor. This is of concern as calibration errors cannot be detected through standard diagnostic tests. The measured calibration errors appear to result from stellar contamination, false object detection, the shear measurement method itself, selection bias and/or the use of biased weights. Additive systematics (false detections of shear) resulting from residual point-spread function anisotropy are, in most cases, reduced to below an equivalent shear of 0.001, an order of magnitude below cosmic shear distortions on the scales probed by current surveys. Our results provide a snapshot view of the accuracy of current ground-based weak lensing methods and a benchmark upon which we can improve. To this end we provide descriptions of each method tested and include details of the eight different implementations of the commonly used Kaiser, Squires and Broadhurst (1995) method (KSB+) to aid the improvement of future KSB+ analyses

Isolated Meningeal Recurrence of Transitional Cell Carcinoma of the Bladder

Meningeal carcinomatosis occurs in 1–18% of patients with solid tumours, most commonly carcinomas of the breast and lung or melanomas. There are relatively few reports of meningeal carcinomatosis in transitional cell carcinoma of the bladder. Isolated meningeal recurrence is particularly uncommon, and we present an unusual case of this in a 58-year-old man. The case was further complicated by the somewhat atypical presentation with a confirmed ischaemic stroke. The patient died one month after presentation

Linkages between mineralogy, fluid chemistry, and microbial communities within hydrothermal chimneys from the Endeavor Segment, Juan de Fuca Ridge

Rock and fluid samples were collected from three hydrothermal chimneys at the Endeavour Segment, Juan de Fuca Ridge to evaluate linkages among mineralogy, fluid chemistry, and microbial community composition within the chimneys. Mössbauer, midinfrared thermal emission, and visible-near infrared spectroscopies were utilized for the first time to characterize vent mineralogy, in addition to thin-section petrography, X-ray diffraction, and elemental analyses. A 282°C venting chimney from the Bastille edifice was composed primarily of sulfide minerals such as chalcopyrite, marcasite, and sphalerite. In contrast, samples from a 300°C venting chimney from the Dante edifice and a 321°C venting chimney from the Hot Harold edifice contained a high abundance of the sulfate mineral anhydrite. Geochemical modeling of mixed vent fluids suggested the oxic-anoxic transition zone was above 100°C at all three vents, and that the thermodynamic energy available for autotrophic microbial redox reactions favored aerobic sulfide and methane oxidation. As predicted, microbes within the Dante and Hot Harold chimneys were most closely related to mesophilic and thermophilic aerobes of the Betaproteobacteria and Gammaproteobacteria and sulfide-oxidizing autotrophic Epsilonproteobacteria. However, most of the microbes within the Bastille chimney were most closely related to mesophilic and thermophilic anaerobes of the Deltaproteobacteria, especially sulfate reducers, and anaerobic hyperthermophilic archaea. The predominance of anaerobes in the Bastille chimney indicated that other environmental factors promote anoxic conditions. Possibilities include the maturity or fluid flow characteristics of the chimney, abiotic Fe2+ and S2− oxidation in the vent fluids, or O2 depletion by aerobic respiration on the chimney outer wall