191 research outputs found
Quantum saturation and condensation of excitons in CuO: a theoretical study
Recent experiments on high density excitons in CuO provide evidence for
degenerate quantum statistics and Bose-Einstein condensation of this nearly
ideal gas. We model the time dependence of this bosonic system including
exciton decay mechanisms, energy exchange with phonons, and interconversion
between ortho (triplet-state) and para (singlet-state) excitons, using
parameters for the excitonic decay, the coupling to acoustic and low-lying
optical phonons, Auger recombination, and ortho-para interconversion derived
from experiment. The single adjustable parameter in our model is the
optical-phonon cooling rate for Auger and laser-produced hot excitons. We show
that the orthoexcitons move along the phase boundary without crossing it (i.e.,
exhibit a ``quantum saturation''), as a consequence of the balance of entropy
changes due to cooling of excitons by phonons and heating by the non-radiative
Auger two-exciton recombination process. The Auger annihilation rate for
para-para collisions is much smaller than that for ortho-para and ortho-ortho
collisions, explaining why, under the given experimental conditions, the
paraexcitons condense while the orthoexcitons fail to do so.Comment: Revised to improve clarity and physical content 18 pages, revtex,
figures available from G. Kavoulakis, Physics Department, University of
Illinois, Urban
Fine structure of excitons in CuO
Three experimental observations on 1s-excitons in CuO are not consistent
with the picture of the exciton as a simple hydrogenic bound state: the
energies of the 1s-excitons deviate from the Rydberg formula, the total exciton
mass exceeds the sum of the electron and hole effective masses, and the
triplet-state excitons lie above the singlet. Incorporating the band structure
of the material, we calculate the corrections to this simple picture arising
from the fact that the exciton Bohr radius is comparable to the lattice
constant. By means of a self-consistent variational calculation of the total
exciton mass as well as the ground-state energy of the singlet and the
triplet-state excitons, we find excellent agreement with experiment.Comment: Revised abstract; 10 pages, revtex, 3 figures available from G.
Kavoulakis, Physics Department, University of Illinois, Urban
Auger decay of degenerate and Bose-condensed excitons in CuO
We study the non-radiative Auger decay of excitons in CuO, in which two
excitons scatter to an excited electron and hole. The exciton decay rate for
the direct and the phonon-assisted processes is calculated from first
principles; incorporating the band structure of the material leads to a
relatively shorter lifetime of the triplet state ortho excitons. We compare our
results with the Auger decay rate extracted from data on highly degenerate
triplet excitons and Bose-condensed singlet excitons in CuO.Comment: 15 pages, revtex, figures available from G. Kavoulaki
Susceptibility to chronic mucus hypersecretion, a genome wide association study
Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoking, but it is unknown why only a minority of smokers develops CMH. A plausible explanation for this phenomenon is a predisposing genetic constitution. Therefore, we performed a genome wide association (GWA) study of CMH in Caucasian populations. Methods: GWA analysis was performed in the NELSON-study using the Illumina 610 array, followed by replication and meta-analysis in 11 additional cohorts. In total 2,704 subjects with, and 7,624 subjects without CMH were included, all current or former heavy smokers (≥20 pack-years). Additional studies were performed to test the functional relevance of the most significant single nucleotide polymorphism (SNP). Results: A strong association with CMH, consistent across all cohorts, was observed with rs6577641 (p = 4.25x10-6, OR = 1.17), located in intron 9 of the special AT-rich sequence-binding protein 1 locus (SATB1) on chromosome 3. The risk allele (G) was associated with higher mRNA expression of SATB1 (4.3x10 -9) in lung tissue. Presence of CMH was associated with increased SATB1 mRNA expression in bronchial biopsies from COPD patients. SATB1 expression was induced during differentiation of primary human bronchial epithelial cells in culture. Conclusions: Our findings, that SNP rs6577641 is associated with CMH in multiple cohorts and is a cis-eQTL for SATB1, together with our additional observation that SATB1 expression increases during epithelial differentiation provide suggestive evidence that SATB1 is a gene that affects CMH
Updated precision measurement of the average lifetime of B hadrons
The measurement of the average lifetime of B hadrons using inclusively reconstructed secondary vertices has been updated using both an improved processing of previous data and additional statistics from new data. This has reduced the statistical and systematic uncertainties and gives \tau_{\mathrm{B}} = 1.582 \pm 0.011\ \mathrm{(stat.)} \pm 0.027\ \mathrm{(syst.)}\ \mathrm{ps.} Combining this result with the previous result based on charged particle impact parameter distributions yields \tau_{\mathrm{B}} = 1.575 \pm 0.010\ \mathrm{(stat.)} \pm 0.026\ \mathrm{(syst.)}\ \mathrm{ps.
Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes
Hundreds of thousands of genetic variants have been reported to cause severe monogenic diseases, but the probability that a variant carrier develops the disease (termed penetrance) is unknown for virtually all of them. Additionally, the clinical utility of common polygenetic variation remains uncertain. Using exome sequencing from 77,184 adult individuals (38,618 multi-ancestral individuals from a type 2 diabetes case-control study and 38,566 participants from the UK Biobank, for whom genotype array data were also available), we apply clinical standard-of-care gene variant curation for eight monogenic metabolic conditions. Rare variants causing monogenic diabetes and dyslipidemias display effect sizes significantly larger than the top 1% of the corresponding polygenic scores. Nevertheless, penetrance estimates for monogenic variant carriers average 60% or lower for most conditions. We assess epidemiologic and genetic factors contributing to risk prediction in monogenic variant carriers, demonstrating that inclusion of polygenic variation significantly improves biomarker estimation for two monogenic dyslipidemias
The importance of visualisation in concept design
This research seeks to advance our understanding of how visualisation can facilitate concept design. It focuses on how designers' use of a specific cognitive process, visualisation, can influence the development of design concepts. The paper presents a conceptual framework that links the type of visualisation (memory vs imagination) and the content of visualisation (incorporation of the end user) to the nature of the design process and to the nature of the design outcome, i.e. its originality, usefulness, and customer appeal. Two experiments are presented that test the propositions that flow from the proposed model. The results indicate that the designer's experience in the design process improves in terms of the difficulty experienced in designing the product and information value, as a function of whether the imaginative visualisation is used, and whether or not the end user is incorporated in the visualisation. Additionally, visualisation, by the designer, that involves both imagination and images of the end user, results in designs that are perceived to be more useful by the end user. This effect, however, is not realised when memory visualisation and images of the end user are combined. Finally, and most importantly, visualising the end user in combination with imagination-based visualisation led to designs that were significantly more appealing to the customer
Narrative transportation in concept tests for really new products : are all protagonists equally convincing?
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