Probing the Physics of Interacting Galaxies

Both Arp 140 and Arp 104 reveal extended tidal tails in the HI. The Halpha and FIR fluxes of Arp 140 yield similar SFR of ~0.8 solar masses per year. In contrast the Halpha flux of Arp 104 yields a SFR of ~0.05 solar masses per year, ~ 20 times smaller than that obtained from the FIR flux. Spectra were used to examine the changing velocity of atomic and molecular gas in NGC 5218 (Arp 104). The atomic and molecular gas were found to be dynamically similar with comparable velocities and velocity widths across the galaxy; consistent with the two phases responding similarly to the interaction, or enhanced HI to CO conversion in the centre of the galaxy

New rotation periods in the Pleiades: Interpreting activity indicators

We present results of photometric monitoring campaigns of G, K and M dwarfs in the Pleiades carried out in 1994, 1995 and 1996. We have determined rotation periods for 18 stars in this cluster. In this paper, we examine the validity of using observables such as X-ray activity and amplitude of photometric variations as indicators of angular momentum loss. We report the discovery of cool, slow rotators with high amplitudes of variation. This contradicts previous conclusions about the use of amplitudes as an alternate diagnostic of the saturation of angular momentum loss. We show that the X-ray data can be used as observational indicators of mass-dependent saturation in the angular momentum loss proposed on theoretical grounds.Comment: 24 pages, LaTex (AASTeX); includes 8 postscript figures and 4 Latex tables. To appear in ApJ, Feb. 1, 1998. Postscript version of preprint can be obtained from http://casa.colorado.edu/~anitak/pubs.htm

VISIR/VLT mid-infrared imaging of Seyfert nuclei: Nuclear dust emission and the Seyfert-2 dichotomy

Half of the Seyfert-2 galaxies escaped detection of broad lines in their polarised spectra observed so far. Some authors have suspected that these non-HBLRs contain real Sy2 nuclei without intrinsic broad line region hidden behind a dust torus. If this were true, then their nuclear structure would fundamentally differ from that of Sy2s with polarised broad lines: in particular, they would not be explained by orientation-based AGN unification. Further arguments for two physically different Sy2 populations have been derived from the warm and cool IRAS F25/F60 ratios. These ratios, however, refer to the entire host galaxies and are unsuitable to conclusively establish the absence of a nuclear dust torus. Instead, a study of the Seyfert-2 dichotomy should be performed on the basis of nuclear properties only. Here we present the first comparison between [OIII] 5007A and mid-infrared imaging at matching spatial resolution. Exploring the Seyfert-2 dichotomy we find that the distributions of nuclear mid-infrared/[OIII] luminosity ratios are indistinguishable for Sy1s and Sy2s with and without detected polarised broad lines and irrespective of having warm or cool IRAS F25/F60 ratios. We find no evidence for the existence of a population of real Sy2s with a deficit of nuclear dust emission. Our results suggest 1) that all Seyfert nuclei possess the same physical structure including the putative dust torus and 2) that the cool IRAS colours are caused by a low contrast of AGN to host galaxy. Then the Seyfert-2 dichotomy is explained in part by unification of non-HBLRs with narrow-line Sy1s and to a larger rate by observational biases caused by a low AGN/host contrast and/or an unfavourable scattering geometry.Comment: 11 pages, 6 figures, accepted by A&

The Fueling and Evolution of AGN: Internal and External Triggers

In this chapter, I review the fueling and evolution of active galactic nuclei (AGN) under the influence of internal and external triggers, namely intrinsic properties of host galaxies (morphological or Hubble type, color, presence of bars and other non-axisymmetric features, etc) and external factors such as environment and interactions. The most daunting challenge in fueling AGN is arguably the angular momentum problem as even matter located at a radius of a few hundred pc must lose more than 99.99 % of its specific angular momentum before it is fit for consumption by a BH. I review mass accretion rates, angular momentum requirements, the effectiveness of different fueling mechanisms, and the growth and mass density of black BHs at different epochs. I discuss connections between the nuclear and larger-scale properties of AGN, both locally and at intermediate redshifts, outlining some recent results from the GEMS and GOODS HST surveys.Comment: Invited Review Chapter to appear in LNP Volume on "AGN Physics on All Scales", Chapter 6, in press. 40 pages, 12 figures. Typo in Eq 5 correcte

The dynamics and efficacy of antiviral RNA silencing: A model study

<p>Abstract</p> <p>Background</p> <p>Mathematical modeling is important to provide insight in the complicated pathway of RNA silencing. RNA silencing is an RNA based mechanism that is widely used by eukaryotes to fight viruses, and to control gene expression.</p> <p>Results</p> <p>We here present the first mathematical model that combines viral growth with RNA silencing. The model involves a plus-strand RNA virus that replicates through a double-strand RNA intermediate. The model of the RNA silencing pathway consists of cleavage of viral RNA into siRNA by Dicer, target cleavage of viral RNA via the RISC complex, and a secondary response. We found that, depending on the strength of the silencing response, different viral growth patterns can occur. Silencing can decrease viral growth, cause oscillations, or clear the virus completely. Our model can explain various observed phenomena, even when they seem contradictory at first: the diverse responses to the removal of RNA dependent RNA polymerase; different viral growth curves; and the great diversity in observed siRNA ratios.</p> <p>Conclusion</p> <p>The model presented here is an important step in the understanding of the natural functioning of RNA silencing in viral infections.</p

Observational evidence for AGN fueling. I. The merging of NGC6104 with a companion

We investigate in details the kinematics and morphology of the Seyfert galaxy NGC6104 in order to identify the mechanism of gas transportation to the active galactic nucleus (AGN). Our observational data were obtained at the 6-m Special Astrophysical Observatory telescope with the MPFS integral-field spectrograph and the SCORPIO universal device in three modes: direct imaging, a scanning Fabry-Perot interferometer, and long-slit spectroscopy. Images from the HST archive were invoked to study the structure of the circumnuclear region. An analysis of deep images has revealed that NGC6104 is in the phase of active merging with a companion galaxy. We have been able to study the detailed picture of ionized gas motions up to galactocentric distances of 14 kpc and to construct the stellar velocity field for the inner region. The radial gas motions toward the AGN along the central bar play a significant role at galactocentric distances of 1-5 kpc. In addition, we have detected an outflow of ionized gas from the nucleus that presumably resulted from the intrusion of a radio jet into the ambient interstellar medium. Using diagnostic diagrams, we estimate the contributions from the AGN and star formation to the galactic gas ionization. We estimate the bar pattern speed by the Tremaine-Weinberg method and show that the inner ring observed in the galactic images has a resonant nature. Two possible ring formation scenarios (before and during the interaction with a companion) are discussed.Comment: 12 pages, 2 tables, 6 figures, accepted for publication in Astronomy Letter

Ribavirin-Induced Anemia in Hepatitis C Virus Patients Undergoing Combination Therapy

The current standard of care for hepatitis C virus (HCV) infection – combination therapy with pegylated interferon and ribavirin – elicits sustained responses in only ∼50% of the patients treated. No alternatives exist for patients who do not respond to combination therapy. Addition of ribavirin substantially improves response rates to interferon and lowers relapse rates following the cessation of therapy, suggesting that increasing ribavirin exposure may further improve treatment response. A key limitation, however, is the toxic side-effect of ribavirin, hemolytic anemia, which often necessitates a reduction of ribavirin dosage and compromises treatment response. Maximizing treatment response thus requires striking a balance between the antiviral and hemolytic activities of ribavirin. Current models of viral kinetics describe the enhancement of treatment response due to ribavirin. Ribavirin-induced anemia, however, remains poorly understood and precludes rational optimization of combination therapy. Here, we develop a new mathematical model of the population dynamics of erythrocytes that quantitatively describes ribavirin-induced anemia in HCV patients. Based on the assumption that ribavirin accumulation decreases erythrocyte lifespan in a dose-dependent manner, model predictions capture several independent experimental observations of the accumulation of ribavirin in erythrocytes and the resulting decline of hemoglobin in HCV patients undergoing combination therapy, estimate the reduced erythrocyte lifespan during therapy, and describe inter-patient variations in the severity of ribavirin-induced anemia. Further, model predictions estimate the threshold ribavirin exposure beyond which anemia becomes intolerable and suggest guidelines for the usage of growth hormones, such as erythropoietin, that stimulate erythrocyte production and avert the reduction of ribavirin dosage, thereby improving treatment response. Our model thus facilitates, in conjunction with models of viral kinetics, the rational identification of treatment protocols that maximize treatment response while curtailing side effects

Exploring Cell Tropism as a Possible Contributor to Influenza Infection Severity

Several mechanisms have been proposed to account for the marked increase in severity of human infections with avian compared to human influenza strains, including increased cytokine expression, poor immune response, and differences in target cell receptor affinity. Here, the potential effect of target cell tropism on disease severity is studied using a mathematical model for in-host influenza viral infection in a cell population consisting of two different cell types. The two cell types differ only in their susceptibility to infection and rate of virus production. We show the existence of a parameter regime which is characterized by high viral loads sustained long after the onset of infection. This finding suggests that differences in cell tropism between influenza strains could be sufficient to cause significant differences in viral titer profiles, similar to those observed in infections with certain strains of influenza A virus. The two target cell mathematical model offers good agreement with experimental data from severe influenza infections, as does the usual, single target cell model albeit with biologically unrealistic parameters. Both models predict that while neuraminidase inhibitors and adamantanes are only effective when administered early to treat an uncomplicated seasonal infection, they can be effective against more severe influenza infections even when administered late

Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses

Influenza virus infection remains a public health problem worldwide. The mechanisms underlying viral control during an uncomplicated influenza virus infection are not fully understood. Here, we developed a mathematical model including both innate and adaptive immune responses to study the within-host dynamics of equine influenza virus infection in horses. By comparing modeling predictions with both interferon and viral kinetic data, we examined the relative roles of target cell availability, and innate and adaptive immune responses in controlling the virus. Our results show that the rapid and substantial viral decline (about 2 to 4 logs within 1 day) after the peak can be explained by the killing of infected cells mediated by interferon activated cells, such as natural killer cells, during the innate immune response. After the viral load declines to a lower level, the loss of interferon-induced antiviral effect and an increased availability of target cells due to loss of the antiviral state can explain the observed short phase of viral plateau in which the viral level remains unchanged or even experiences a minor second peak in some animals. An adaptive immune response is needed in our model to explain the eventual viral clearance. This study provides a quantitative understanding of the biological factors that can explain the viral and interferon kinetics during a typical influenza virus infection