Choroid Plexus Papillomas in two Siblings: Case Report [İki Kardeşte Görülen Koroid Pleksus Papillomu: Olgu Sunumu]

Choroid plexus papilloma (CPP) is a rare, benign epithelial brain tumor of the nervous system seen particularly in infants. Familial cases are extremely uncommon. Some other form of malignant tumors was noted in the relatives of patients with CPPs, and some genetic defects regarding this coincidence were reported in the literature. These neoplasms are occasionally bilateral and hydrocephalus is an associated sign in most of the cases. We report three lateral ventricle CPPs in two siblings, at the age of 7 month and 2 years respectively. All tumors were resected with parietotemporal craniotomy and a superior temporal sulcus approach to the lateral ventricle. To avoid a concomitant need of ventriculoperitoneal shunt insertion, external ventricular drainage was inserted for a week in the postoperative period relieving symptoms of hydrocephalus. Search for a hereditary defect in the p53 gene of the second infant (7 months old) revealed no mutation. Postoperative courses were uneventful and the patients were followed for three years without any recurrence. Bilateral CPPS are rare and unusual in two siblings. A genetic predisposition such as the p53 mutation should be investigated in bilateral CPPs in particular

Occurrence of fumonisin in processed and low processed corn-based products in Turkey

A total of 92 corn-based food products consisting of 53 low-processed and 39 processed samples were collected at random from retail markets and bazaars in various provinces of Turkey and analysed for total fumonisin levels. Twenty oneTwenty-one (40%) low-processed and nine (23%) processed samples were found to contain fumonisin. Total fumonisin contamination in the low-processed products ranged from 0.8 to 273 273 mg. mg kg-1, and in the processed products from 0.3 to 76.8 mg kg-. Considering all 92 samples, the highest frequency of detection and also the highest concentrations (in flour samples up to 273 mg kg-1) were detected in low-processed products. These results indicated the natural contamination of fumonisins corn-based low-processed and processed food products for human consumption in Turkey by fumonisins

Determination of pharmaceutical active compounds in Ceyhan River, Turkey: Seasonal, spatial variations and environmental risk assessment

Pharmaceutical pollution has gained attention with the development of analytical technology. The occurrence of 91 pharmaceutically active compounds from variety of drug groups including pain killers, antimicrobials, cardiovascular drugs, hypolipidemic drugs, central nervous system drugs, and stimulants was investigated in Ceyhan River, Turkey. Pharmaceutically active compounds were examined at 9 stations, seasonally during the periods of September 2013–August 2014. For the pharmaceutically active compound analysis, solid phase extraction (SPE) method was used and measured by using liquid chromatography tandem mass spectrometry (LC-MS/MS). Highest measured pharmaceutically active compound concentration was caffeine (4880.00 ng/L). Other high concentrated pharmaceuticals were diazepam (374.00 ng/L), gabapentin (355.00 ng/L), lidocaine (48.70 ng/L), etodolac (47.35 ng/L), metoprolol (43.60 ng/L), carbamazepine (24.25 ng/L), diclofenac (17.60 ng/L), and fluconazole (15.95 ng/L). Carbamazepine and lidocaine were the most frequently detected pharmaceutics in the river water. The results of risk assessment shows that risk quotient values (RQs) is lower than 0.01, except sertraline, which means that most of the detected pharmaceutically active compounds pose no environmental risk to aquatic environment in Ceyhan River. However, it is not possible to give precise information about the effects of all detected pharmaceutically active compounds when they behave together in the aquatic environment. © 2018, © 2018 Taylor & Francis Group, LLC.Cukurova University, Teaching Staff Trainee Program (OYP) provided the financial support for this work

Occurrence and seasonal changes of N,N-Diethyl-m-Toluamide (Deet) pesticide in middle south Turkey surface waters

N, N-diethyl-m-toluamide (DEET) is a widely used insect repellent and a very effective pesticide applied to skin or clothing to remove insects or rodents. It is also among personal care products. DEET can be toxic to birds, fishes and aquatic invertebrates. For this reason, determination of concentrations in surface waters is very important for living things that live in or feed in aquatic environments. This work was carried out in Ivriz, Ayrancı, Godet, Sucullu, Uluborlu, Kozan, Mehmetli, Seyhan Dam Lakes, Golbasi, Azapli, Inekli Lakes and Ceyhan River in the Middle South of Turkey. During this study, DEET was detected in all surface water samples taken from lakes and Ceyhan River and the obtained average DEET concentrations are ranged from 0.57 to 80.10 ng/l. The highest concentration obtained was found in the Ceyhan River in summer. When the averages of DEET concentrations are listed, the first three are Ceyhan River, Golbasi Lake and Seyhan Dam Lake, respectively. Higher DEET concentrations were found in summer in most lakes and Ceyhan River. Despite the fact that the measured DEET concentrations in surface waters are well below the acute effect concentrations, but it is not known exactly how their effects will be when DEET behave with the other pollutants. © 2018, Scibulcom Ltd. All rights reserved

The effectiveness of hesperidin in the prevention of bacterial translocation caused by methotrexate in the gastrointestinal tract [Metotreksati{dotless}n neden oldugu gastrointestinal kanaldan bakteriyel translokasyonun önlenmesinde hesperidinin etkinligi]

Methotrexate (MTX) is an antimetabolite that it is widely used in childhood cancers. Gastrointestinal toxicity stemming from oxidative damage is an important factor limiting its use. MTX causes morphological damage in the mucosa of the small intestine and serious barrier function disorder. Bacterial translocation can be seen when intestinal barrier functions are deteriorated. The aim of this study was to investigate the effect of hesperidin, a powerful antioxidant, in the prevention of bacterial translocation caused by MTX. Rats were given a single intraperitoneal dose of MTX at 20 mg/kg body weight. Hesperidin was given with oral gavage at 200 mg/kg body weight through 5 days. On the 6th day, biopsy specimens from the ileocecal region, ascending colon and mesenteric lymph nodes were placed in culture media. Increased intestinal bacteria growth was found and prominent bacterial translocation were determined in the MTX group (P<0.05). Hesperidin significantly reduced the growth load and bacterial translocation. This study showed that hesperidin protects against translocation by preventing damage caused by MTX

Pesticide intoxications in Cukurova, Turkey: Three years analysis

PubMedID: 21393348In Cukurova region, pesticide poisonings still remain an unfortunate cause of death, which led to the present study. The autopsy records of Adana Branch of the Council of Forensic Medicine, between 2006 and 2008, were evaluated retrospectively. Deaths that were attributed to pesticide poisoning were included in the scope of the study to identify the type of pesticide, and etiology of intoxication. The frequency and distribution of intoxications were also analyzed in terms of sex and age. In the studied period, a total of 4199 autopsies were referred to the forensic toxicology laboratory for pesticide analysis. Seventy-two cases were positive for pesticide analysis. Of these, 42 (58.33%) were male and 30 (41.67%) were female, with a mean age of 38.8 ± 20.6 years. Among the inspected pesticides, endosulfan was found to be the most common with 47.2% of prevalence, followed by dichlorvos. This report showed that certain pesticides, endosulfan in particular, remains as common cause of poisonings in Cukurova region. © The Author(s) 2011