7,831 research outputs found
Localizing the Latent Structure Canonical Uncertainty: Entropy Profiles for Hidden Markov Models
This report addresses state inference for hidden Markov models. These models
rely on unobserved states, which often have a meaningful interpretation. This
makes it necessary to develop diagnostic tools for quantification of state
uncertainty. The entropy of the state sequence that explains an observed
sequence for a given hidden Markov chain model can be considered as the
canonical measure of state sequence uncertainty. This canonical measure of
state sequence uncertainty is not reflected by the classic multivariate state
profiles computed by the smoothing algorithm, which summarizes the possible
state sequences. Here, we introduce a new type of profiles which have the
following properties: (i) these profiles of conditional entropies are a
decomposition of the canonical measure of state sequence uncertainty along the
sequence and makes it possible to localize this uncertainty, (ii) these
profiles are univariate and thus remain easily interpretable on tree
structures. We show how to extend the smoothing algorithms for hidden Markov
chain and tree models to compute these entropy profiles efficiently.Comment: Submitted to Journal of Machine Learning Research; No RR-7896 (2012
Chiral QCD, General QCD Parameterization and Constituent Quark Models
Several recent papers -using effective QCD chiral Lagrangians- reproduced
results obtained with the general QCD parameterization (GP). These include the
baryon 8+10 mass formula, the octet magnetic moments and the coincidental
nature of the "perfect" -3/2 ratio between the magnetic moments of p and n.
Although we anticipated that the GP covers the case of chiral treatments, the
above results explicitly exemplify this fact. Also we show by the GP that -in
any model or theory (chiral or non chiral) reproducing the results of exact
QCD- the Franklin (Coleman Glashow) sum rule for the octet magnetic moments
must be violated.Comment: 10 pages, Latex; abridged version (same results), removed some
reference
Analysis of dynamical corrections to baryon magnetic moments
We present and analyze QCD corrections to the baryon magnetic moments in
terms of the one-, two-, and three-body operators which appear in the effective
field theory developed in our recent papers. The main corrections are extended
Thomas-type corrections associated with the confining interactions in the
baryon. We investigate the contributions of low-lying angular excitations to
the moments quantitatively and show that they are completely negligible. When
the QCD corrections are combined with the non-quark model contributions of the
meson loops, we obtain a model which describes the moments within a mean
deviation of 0.04 . The nontrivial interplay of the two types of
corrections to the quark-model moments is analyzed in detail, and explains why
the quark model is so successful. In the course of these calculations, we
parametrize the general spin structure of the baryon wave functions
in a form which clearly displays the symmetry properties and the internal
angular momentum content of the wave functions, and allows us to use spin-trace
methods to calculate the many spin matrix elements which appear in the
expressions for the moments. This representation may be useful elsewhere.Comment: 32 pages, 3 figures, submitted to Phys. Rev.
Sudden To Adiabatic Transition in Beta Decay
We discuss effects in beta decays at very low beta energies, of the order of
the kinetic energies of atomic electrons. As the beta energy is lowered the
atomic response changes from sudden to adiabatic. As a consequence, the beta
decay rate increases slightly and the ejection of atomic electrons (shake off)
and subsequent production of X rays is turned off. We estimate the transition
energy and the change in decay rate. The rate increase is largest in heavy
atoms, which have a small Q value in their decay. The X ray switch-off is
independent of Q value.Comment: 6 pages LaTe
Stability of the Zagreb Carnegie-Mellon-Berkeley model
In ref. [1] we have used the Zagreb realization of Carnegie-Melon-Berkeley
coupled-channel, unitary model as a tool for extracting pole positions from the
world collection of partial wave data, with the aim of eliminating model
dependence in pole-search procedures. In order that the method is sensible, we
in this paper discuss the stability of the method with respect to the strong
variation of different model ingredients. We show that the Zagreb CMB procedure
is very stable with strong variation of the model assumptions, and that it can
reliably predict the pole positions of the fitted partial wave amplitudes.Comment: 25 pages, 12 figures, 19 table
Label-free detection of anticancer drug paclitaxel in living cells by confocal Raman microscopy
Confocal Raman microscopy, a non-invasive, label-free, and high spatial resolution imaging technique is employed to trace the anticancer drug paclitaxel in living Michigan Cancer Foundation-7 (MCF-7) cells. The Raman images were treated by K-mean cluster analysis to detect the drug in cells. Distribution of paclitaxel in cells is verified by calculating the correlation coefficient between the reference spectrum of the drug and the whole Raman image spectra. A time dependent gradual diffusion of paclitaxel all over the cell is observed suggesting a complementary picture of the pharmaceutical action of this drug based on rapid binding of free tubulin to crystallized paclitaxel. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4794871
Effective field theory and the quark model
We analyze the connections between the quark model (QM) and the description
of hadrons in the low-momentum limit of heavy-baryon effective field theory in
QCD. By using a three-flavor-index representation for the effective baryon
fields, we show that the ``nonrelativistic'' constituent QM for baryon masses
and moments is completely equivalent through O(m_s) to a parametrization of the
relativistic field theory in a general spin--flavor basis. The flavor and spin
variables can be identified with those of effective valence quarks. Conversely,
the spin-flavor description clarifies the structure and dynamical
interpretation of the chiral expansion in effective field theory, and provides
a direct connection between the field theory and the semirelativistic models
for hadrons used in successful dynamical calculations. This allows dynamical
information to be incorporated directly into the chiral expansion. We find, for
example, that the striking success of the additive QM for baryon magnetic
moments is a consequence of the relative smallness of the non-additive
spin-dependent corrections.Comment: 25 pages, revtex, no figure
Octet Magnetic Moments with Null Instantons and Semibosonized Nambu-Jona-Lasinio Model
It is shown that the difference between the magnetic moment results in the
quark model with null instantons and semibosonized Nambu-Jona-Lasinio model
lies in the description of the magnetic moment of the -hyperon.Comment: RevTex, 6 pages, submitted to Progr.Theor.Phy
Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone.
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy. METHODS: Method and outcome classification of the study complied with WHO guidelines. Children 6-59 months with uncomplicated malaria were followed-up for 28 days. PCR genotyping was used to distinguish recrudescence from reinfection. Reinfections were reclassified as cured. RESULTS: Of 172 children who were referred to the study clinic, 126 satisfied inclusion criteria and were enrolled. No early treatment failures were reported. The day 14, efficacy was 98.2% (95% CI: 93.8-99.8). Of 65 recurrent parasitaemias analysed by PCR, 17 were recrudescences. The PCR-adjusted day 28 efficacy was 84.5% (95% CI: 76.4-90.7). All true failures occurred in the last 8 days of follow-up. Of 110 children who completed the 28-day follow-up, 54 (49.1%) experienced a novel infection. CONCLUSION: The efficacy of this combination was disappointing. The high reinfection rate suggested little prophylactic effect. In Kailahun a more efficacious combination might be necessary in the future. The efficacy of AS + AQ needs to be monitored in Kailahun and in the other regions of Sierra Leone
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