IUE ultraviolet observations of W UM a Stars

International Ultraviolet Explorer observations of four W UMa eclipsing binary systems (44 Boo, VW Cep, W UMa, and epsilon) are discussed. The stars generally show large surface fluxes of high temperature lines (C II, C IV, N V, Si IV) which may result from the high rotational velocities forced by synchronous rotation. High dispersion spectra of the 44 Boo system in the Mg II line enable the individual stellar components to be identified. The line widths and phase variations are consistent with the optically determined spectroscopic orbit. Circumstellar absorption of Mg II may be presented at selected phases

X-Ray Determination of the Variable Rate of Mass Accretion onto TW Hydrae

Diagnostics of electron temperature (T_e), electron density (n_e), and hydrogen column density (N_H) from the Chandra High Energy Transmission Grating spectrum of He-like Ne IX in TW Hydrae (TW Hya), in conjunction with a classical accretion model, allow us to infer the accretion rate onto the star directly from measurements of the accreting material. The new method introduces the use of the absorption of Ne IX lines as a measure of the column density of the intervening, accreting material. On average, the derived mass accretion rate for TW Hya is 1.5 x 10^{-9} M_{\odot} yr^{-1}, for a stellar magnetic field strength of 600 Gauss and a filling factor of 3.5%. Three individual Chandra exposures show statistically significant differences in the Ne IX line ratios, indicating changes in N_H, T_e, and n_e by factors of 0.28, 1.6, and 1.3, respectively. In exposures separated by 2.7 days, the observations reported here suggest a five-fold reduction in the accretion rate. This powerful new technique promises to substantially improve our understanding of the accretion process in young stars

Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner

Background Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has been shown that during chronic inflammation, neuronal integrity is compromised through targeted disruption of the axon initial segment (AIS), the axonal domain critical for action potential initiation. AIS disruption was associated with contact by reactive inflammatory microglia which wrap around the AIS, increasing association with disease progression. While it is clear that chronic microglial inflammation and enhanced ROS production impact neuronal integrity, little is known about how acute microglial inflammation influences AIS stability. Here, we demonstrate that acute neuroinflammation induces AIS structural plasticity in a ROS-mediated and calpain-dependent manner. Methods C57BL/6J and NOX2−/− mice were given a single injection of lipopolysaccharide (LPS; 5 mg/kg) or vehicle (0.9% saline, 10 mL/kg) and analyzed at 6 h–2 weeks post-injection. Anti-inflammatory Didox (250 mg/kg) or vehicle (0.9% saline, 10 mL/kg) was administered beginning 24 h post-LPS injection and continued for 5 days; animals were analyzed 1 week post-injection. Microglial inflammation was assessed using immunohistochemistry (IHC) and RT-qPCR, and AIS integrity was quantitatively analyzed using ankyrinG immunolabeling. Data were statistically compared by one-way or two-way ANOVA where mean differences were significant as assessed using Tukey’s post hoc analysis. Results LPS-induced neuroinflammation, characterized by enhanced microglial inflammation and increased expression of ROS-producing enzymes, altered AIS protein clustering. Importantly, inflammation-induced AIS changes were reversed following resolution of microglial inflammation. Modulation of the inflammatory response using anti-inflammatory Didox, even after significant AIS disruption occurred, increased the rate of AIS recovery. qPCR and IHC analysis revealed that expression of microglial NOX2, a ROS-producing enzyme, was significantly increased correlating with AIS disruption. Furthermore, ablation of NOX2 prevented inflammation-induced AIS plasticity, suggesting that ROS drive AIS structural plasticity. Conclusions In the presence of acute microglial inflammation, the AIS undergoes an adaptive change that is capable of spontaneous recovery. Moreover, recovery can be therapeutically accelerated. Together, these findings underscore the dynamic capabilities of this domain in the presence of a pathological insult and provide evidence that the AIS is a viable therapeutic target

Combined ultraviolet studies of astronomical sources

Topics addressed include: Cygnus Loop; P Cygni profiles in dwarf novae; YY Gem; nova shells; HZ Herculis; activity cycles in cluster giants; Alpha Ori; metal deficient giant stars; ultraviolet spectra of symbiotic stars detected by the Very Large Array; time variability in symbiotic stars; blue galaxies; and quasistellar objects with X-ray spectra

TW Hya: Spectral Variability, X-Rays, and Accretion Diagnostics

The nearest accreting T Tauri star, TW Hya was observed with spectroscopic and photometric measurements simultaneous with a long se gmented exposure using the CHANDRA satellite. Contemporaneous optical photometry from WASP-S indicates a 4.74 day period was present during this time. Absence of a similar periodicity in the H-alpha flux and the total X-ray flux points to a different source of photometric variations. The H-alpha emission line appears intrinsically broad and symmetric, and both the profile and its variability suggest an origin in the post-shock cooling region. An accretion event, signaled by soft X-rays, is traced spectroscopically for the first time through the optical emission line profiles. After the accretion event, downflowing turbulent material observed in the H-alpha and H-beta lines is followed by He I (5876A) broadening. Optical veiling increases with a delay of about 2 hours after the X-ray accretion event. The response of the stellar coronal emission to an increase in the veiling follows about 2.4 hours later, giving direct evidence that the stellar corona is heated in part by accretion. Subsequently, the stellar wind becomes re-established. We suggest a model that incorporates this sequential series of events: an accretion shock, a cooling downflow in a supersonically turbulent region, followed by photospheric and later, coronal heating. This model naturally explains the presence of broad optical and ultraviolet lines, and affects the mass accretion rates determined from emission line profiles.Comment: 61 pages; 22 figures; to appear in The Astrophysical Journa