The Clinical Significance of Subclinical Thyroid Dysfunction.

Subclinical thyroid disease (SCTD) is defined as serum free T(4) and free T(3) levels within their respective reference ranges in the presence of abnormal serum TSH levels. SCTD is being diagnosed more frequently in clinical practice in young and middle-aged people as well as in the elderly. However, the clinical significance of subclinical thyroid dysfunction is much debated. Subclinical hyper- and hypothyroidism can have repercussions on the cardiovascular system and bone, as well as on other organs and systems. However, the treatment and management of SCTD and population screening are controversial despite the potential risk of progression to overt disease, and there is no consensus on the thyroid hormone and thyrotropin cutoff values at which treatment should be contemplated. Opinions differ regarding tissue effects, symptoms, signs, and cardiovascular risk. Here, we critically review the data on the prevalence and progression of SCTD, its tissue effects, and its prognostic implications. We also examine the mechanisms underlying tissue alterations in SCTD and the effects of replacement therapy on progression and tissue parameters. Lastly, we address the issue of the need to treat slight thyroid hormone deficiency or excess in relation to the patient's ag

Non-Hodgkin’s Lymphoma of the Uterine Cervix

Non Hodgkin’s Lymphoma (NHL) causes many deaths worldwide and its incidence is increasing. They occur commonly in middle aged and elderly people and are disseminated at diagnosis. We present an interesting case of NHL in a 52 years old female, who presented with past a history of postmenopausal bleeding. A 3 x 5 cms endocervical polyp was noticed in the cervix. Biopsy of the polyp revealed it to be a CD20-positive diffuse large B-cell (DLBCL)-type NHL. She was diagnosed as stage IE after staging work-up. She attained a complete response, and has been in remission for 1 year 8 months

A Historical Perspective on Runtime Assertion Checking in Software Development

This report presents initial results in the area of software testing and analysis produced as part of the Software Engineering Impact Project. The report describes the historical development of runtime assertion checking, including a description of the origins of and significant features associated with assertion checking mechanisms, and initial findings about current industrial use. A future report will provide a more comprehensive assessment of development practice, for which we invite readers of this report to contribute information

The linear dependence relations and truncation errors for interpolating even order splines

Linear dependence relations are derived for even order polynomial splines defined over the points midway between a uniformly spaced set of knots. The leading term of the truncation error is determined and is illustrated by an example

Enabling Confidentiality in Content-Based Publish/Subscribe Infrastructures

Content-Based Publish/Subscribe (CBPS) is an interaction model where the interests of subscribers are stored in a content-based forwarding infrastructure to guide routing of notifications to interested parties. In this paper, we focus on answering the following question: Can we implement content-based publish/subscribe while keeping subscriptions and notifications confidential from the forwarding brokers? Our contributions include a systematic analysis of the problem, providing a formal security model and showing that the maximum level of attainable security in this setting is restricted. We focus on enabling provable confidentiality for commonly used applications and subscription languages in CBPS and present a series of practical provably secure protocols, some of which are novel and others adapted from existing work. We have implemented these protocols in SIENA, a popular CBPS system. Evaluation results show that confidential content-based publish/subscribe is practical: A single broker serving 1000 subscribers is able to route more than 100 notifications per second with our solutions

Resonance equals reducibility for A-hypergeometric systems

Classical theorems of Gel'fand et al., and recent results of Beukers, show that non-confluent Cohen-Macaulay A-hypergeometric systems have reducible monodromy representation if and only if the continuous parameter is A-resonant. We remove both the confluence and Cohen-Macaulayness conditions while simplifying the proof.Comment: 9 pages, final versio

Reliability Analysis of Concurrent Systems using LTSA

The analysis for software dependability is considered an important task within the software engineering life cycle. However, it is often impossible to carry out this task due to the complexity of available tools, lack of expert personnel and time-to-market pressures. As a result, released software versions may present unverified dependability properties subjecting customers to blind software reliability assessment. In particular, concurrent systems present certain behaviour that require a more complex system analysis not easily grasped at system design and architecture level

Mechanical properties of a degradable phosphate glass fibre reinforced polymer composite for internal fracture fixation

NOTICE: this is the author’s version of a work that was accepted for publication in Materials Science and Engineering. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Science and Engineering, [VOL 30, ISSUE 7, (2010)] DOI: 10.1016/j.msec.2010.04.017