427 research outputs found
Demodex spp.
Los ácaros ectoparásitos del género Demodex spp (>140 especies) pertenecen a la familia Demodicidae, superfamilia Cheyletoidea, suborden Prostigmata, orden Trombidiformes, superorden Acariformes. Fueron descritos por primera vez en 1841 por Henle y Berger. El término Demodex deriva del griego: demos = grasa y dex = gusano incrustado.Tienen una longitud de 0.2- 0.4 mm, son transparentes y elongados. Su cuerpo se divide en tres secciones principales: 1) gnatosoma, región anterior, en donde se encuentra la apertura bucal; 2) podosoma, región en la que se encuentran sus cuatro pares de patas; y 3) el opistoma, región caudal o cola.Se adquieren poco después del nacimiento y se consideran parte del microbiota normal de muchos mamÃferos, asà como también del ser humano, en particular de la unidad pilosebácea. Por lo tanto, se ubican principalmente en el rostro, cuero cabelludo y región superior del tronco. Todas estas áreas corporales se caracterizan por la alta secreción sebácea, alimento primordial para el crecimiento y desarrollo de este ácaro; razón por la cual, además, su densidad aumenta durante la pubertad, periodo cuando proliferan las glándulas sebáceas. Dentro de las especies del género, encontramos exclusivamente en humanos, a D. folliculorum (440 µm), habitando frecuentemente el infundÃbulo folicular y D. brevis (240 µm), que se localiza predominantemente en los ductos sebáceos y glándulas tarsales a nivel ocular
Métodos tradicionales para purificar el agua
Ante la indisponibilidad de proveerse de este lÃquido vital, en muchos sectores rurales, urbano marginales, de nuestro paÃs y a lo mejor incluso por la mala utilización en los centros urbanos de el agua potable, he creido conveniente hacer uso de este espacio, para exponer algunas formas caseras y sencillas de purificación de el agua
Development of Mobile Application that Detects Phishing Messages to Decrease the Percentage of Data Theft during the COVID-19 Pandemic
The COVID-19 pandemic has established not only a health emergency, but has generated an emergency in the control of personal data of all those people who make use of technological means, which increased the activity of phishing which consists of the theft of personal data through the circulation of false information through the different social networks, in addition, the circulation with messages related to the cure of this disease only for the theft of data. This research develops a mobile application that detects malicious URLs found within the content of textmessages. The developed application performs an analysis of the URLs according to the database that is updated with each attack detected, performing a blocking of the content and notifies the user of the actions that canbetaken, with this the theft of the personal data of the users is avoided. This application is very useful for all those people who use mobile equipment (mobile) and have no knowledge of these types of attacks, since they are likely to perform the actions that the perpetrators foresee for the obtaining of their personal data, so this application provides a means of security against these types of phishing attacks
Ischemic Preconditioning Improves the Bench-Press Maximal Strength in Resistance-Trained Men
International Journal of Exercise Science 16(4): 217-229, 2023. We investigated whether acute ischemic preconditioning (IPC) would affect upper limb maximal strength performance in resistance-trained men. Using a counterbalanced randomized crossover design, fifteen men (29.9 ± 5.9 yrs.; 86.3 ± 9.6 kg; 8.0 ± 5.0 yrs. resistance training experience) performed one-repetition maximum (1-RM) bench press tests on three different occasions: control, 10 min post-IPC or 10 min post-placebo (SHAM). One-way analysis of variance showed that the post-IPC condition increased (P \u3c 0.0001) 1-RM loads compared to both control and post-SHAM (control 113.3 ± 15.9 kg vs. SHAM 113.9 ± 15.8 kg vs. IPC 115.7 ± 15.6 kg), while control and SHAM did not differ (P \u3e 0.05). Individual results showed that 13 participants (~87%) improved their performance post-IPC compared to control, and 11 participants (~73%) performed better post-IPC compared to post-SHAM. Reported session rating of perceived exertion (RPE) was lower (P \u3c 0.0001) post-IPC (8.5 ± 0.6 arb.u) compared to control (9.3 ± 0.5 arb.u) and post-SHAM (9.3 ± 0.5 arb.u). Therefore, we conclude that IPC acutely improves upper limb maximal strength performance and reduces session-RPE in resistance-trained men. These results suggest an acute ergogenic effect of IPC for strength and power sports such as powerlifting
Perturbed mitochondria-ER contacts in live neurons that model the amyloid pathology of Alzheimer\u27s disease.
The use of fixed fibroblasts from familial and sporadic Alzheimer\u27s disease patients has previously indicated an upregulation of mitochondria-ER contacts (MERCs) as a hallmark of Alzheimer\u27s disease. Despite its potential significance, the relevance of these results is limited because they were not extended to live neurons. Here we performed a dynamic in vivo analysis of MERCs in hippocampal neurons from McGill-R-Thy1-APP transgenic rats, a model of Alzheimer\u27s disease-like amyloid pathology. Live FRET imaging of neurons from transgenic rats revealed perturbed \u27lipid-MERCs\u27 (gap width \u3c10 nm), while \u27Ca2+-MERCs\u27 (10-20 nm gap width) were unchanged. In situ TEM showed no significant differences in the lipid-MERCs:total MERCs or lipid-MERCs:mitochondria ratios; however, the average length of lipid-MERCs was significantly decreased in neurons from transgenic rats as compared to controls. In accordance with FRET results, untargeted lipidomics showed significant decreases in levels of 12 lipids and bioenergetic analysis revealed respiratory dysfunction of mitochondria from transgenic rats. Thus, our results reveal changes in MERC structures coupled with impaired mitochondrial functions in Alzheimer\u27s disease-related neurons.This article has an associated First Person interview with the first author of the paper
Lactate Regulates Metabolic and Proinflammatory Circuits in Control of T Cell Migration and Effector Functions
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