Situational Context and Marked Code-Switching

Based on Halliday’s theory of register, this paper concerns about marked code-switching from the perspective of sociolinguistic situational context. Marked code-switching does not happen at random, but a kind of rational behavior. The data are gathered from utterances occurred in different situational contexts, by which and based on the field, tenor and mode of register, this research has made a deep analysis on marked code-switch, its socio-pragmatic functions and psychological motivations as well. It does have some research value either in theory and application since there is seldom research done about the marked code-switching phenomenon from the perspective of register theory. Keywords: register theory; marked code-switching; socio-pragmatic functions Résumé: Sur la base de la théorie de registre de Halliday, cet article s’intéresse sur le code-switching marqué à partir de la perspective du contexte situationnel sociolinguistique. Le Code-switching marqué ne se fait pas au hasard. C’est une sorte de procédé rationnel. Les données sont recueillies à partir des énoncés produits dans de différents contextes situationnels et la recherche a fait une analyse profonde sur le code-switching marqué, ses fonctions socio-pragmatiques et aussi les motivations psychologiques. Elle possède une certaine valeur de recherche dans la théorie et dans l'application, car les recherches sur le phénomène de code-switching marqué sont rarement faites dans la perspective de la théorie de registre. Mots-clés: la théorie de register; le code-switching marqué; les fonctions socio-pragmatiques 摘 要：本文從社會語言學的情景語境角度，借助Halliday的語域理論探討在語言的使用中有標記語碼轉換現象。 有標記語碼轉換不是盲目隨意的，而是一種理性行為。本文以一些生活中的情景語境片段為語料，從語域理論的語場、語勢和語式三維變項角度分析了有標記語碼轉換現象、有標記語碼轉換的社會語用和心理動機。將語域理論用於研究有標記語碼轉換的研究不甚多見，因此本研究具有一定的理論和應用價值。 關鍵詞：語域理論；有標記語碼轉換；社會語用功

The elliptic quantum algebra Uq,p(slN^)U_{q,p}(\hat{sl_N}) and its vertex operators

We construct a realization of the elliptic quantum algebra $U_{q,p}(\hat{sl_N})$ for any given level $k$ in terms of free boson fields and their twisted partners. It can be considered as the elliptic deformation of the Wakimoto realization of the quantum affine algebra $U_{q}(\hat{sl_N})$. We also construct a family of screening currents, which commute with the currents of $U_{q,p}(\hat{sl_N})$ up to total q-differences. And we give explicit twisted expressions for the type $I$ and the type $II$ vertex operators of $U_{q,p}(\hat{sl_N})$ by twisting the known results of the type $I$ vertex operators of the quantum affine algebra $U_{q}(\hat{sl_N})$ and the new results of the type $II$ vertex operators of $U_{q}(\hat{sl_N})$ we obtained in this paper.Comment: 28 page

Antiaging Effect of Pine Pollen in Human Diploid Fibroblasts and in a Mouse Model Induced by D-Galactose

The present paper was designed to investigate the effect of pine pollen against aging in human diploid fibroblast 2BS cells and in an accelerated aging model, which was established by subcutaneous injections with D-galactose daily for 8 weeks in C57BL/6J mice. Pine pollen (1 mg/mL and 2 mg/mL) is proved to delay the replicative senescence of 2BS cells as evidenced by enhanced cell proliferation, decreased SA-β-Gal activity, and reversed expression of senescence-associated molecular markers, such as p53, p21Waf1, p16INK4a, PTEN, and p27Kip1 in late PD cells. Besides, pine pollen reversed D-galactose-induced aging effects in neural activity and inflammatory cytokine levels, as indicated by improved memory latency time and reduced error rate in step-down test and decreased concentrations of IL-6 and TNF-α in model mice. Similar to the role of AGEs (advanced glycation endproducts) formation inhibitor aminoguanidine (AG), pine pollen inhibited D-galactose-induced increment of AGEs levels thus reversed the aging phenotypes in model mice. Furthermore, the declined antioxidant activity was obviously reversed upon pine pollen treatment, which may account for its inhibitory effect on nonenzymatic glycation (NEG) in vivo. Our finding presents pine pollen as an attractive agent with potential to retard aging and attenuate age-related diseases in humans

A proposed disease classification system for duck viral hepatitis

The nomenclature of duck viral hepatitis (DVH) was historically not a problem. However, 14 hepatotropic viruses among 10 different genera are associated with the same disease name, DVH. Therefore, the disease name increasingly lacks clarity and may no longer fit the scientific description of the disease. Because one disease should not be attributed to 10 genera of viruses, this almost certainly causes misunderstanding regarding the disease-virus relationship. Herein, we revisited the problem and proposed an update to DVH disease classification. This classification is based on the nomenclature of human viral hepatitis and the key principle of Koch's postulates (“one microbe and one disease”). In total, 10 types of disease names have been proposed. These names were literately matched with hepatitis-related viruses. We envision that this intuitive nomenclature system will facilitate scientific communication and consistent interpretation in this field, especially in the Asian veterinary community, where these diseases are most commonly reported

FAST observations of an extremely active episode of FRB 20201124A: IV. Spin Period Search

We report the properties of more than 800 bursts detected from the repeating fast radio burst (FRB) source FRB 20201124A with the Five-hundred-meter Aperture Spherical radio telescope (FAST) during an extremely active episode on UTC September 25th-28th, 2021 in a series of four papers. In this fourth paper of the series, we present a systematic search of the spin period and linear acceleration of the source object from both 996 individual pulse peaks and the dedispersed time series. No credible spin period was found from this data set. We rule out the presence of significant periodicity in the range between 1 ms to 100 s with a pulse duty cycle $< 0.49\pm0.08$ (when the profile is defined by a von-Mises function, not a boxcar function) and linear acceleration up to $300$ m s$^{-2}$ in each of the four one-hour observing sessions, and up to $0.6$ m s$^{-2}$ in all 4 days. These searches contest theoretical scenarios involving a 1 ms to 100 s isolated magnetar/pulsar with surface magnetic field $<10^{15}$ G and a small duty cycle (such as in a polar-cap emission mode) or a pulsar with a companion star or black hole up to 100 M$_{\rm \odot}$ and $P_b>10$ hours. We also perform a periodicity search of the fine structures and identify 53 unrelated millisecond-timescale "periods" in multi-components with the highest significance of 3.9 $\sigma$. The "periods" recovered from the fine structures are neither consistent nor harmonically related. Thus they are not likely to come from a spin period. We caution against claiming spin periodicity with significance below $\sim$ 4 $\sigma$ with multi-components from one-off FRBs. We discuss the implications of our results and the possible connections between FRB multi-components and pulsar micro-structures.Comment: Accepted by Research in Astronomy and Astrophysics (RAA

Microlensing as a probe of the Galactic structure; 20 years of microlensing optical depth studies

Microlensing is now a very popular observational astronomical technique. The investigations accessible through this effect range from the dark matter problem to the search for extra-solar planets. In this review, the techniques to search for microlensing effects and to determine optical depths through the monitoring of large samples of stars will be described. The consequences of the published results on the knowledge of the Milky-Way structure and its dark matter component will be discussed. The difficulties and limitations of the ongoing programs and the perspectives of the microlensing optical depth technique as a probe of the Galaxy structure will also be detailed.Comment: Accepted for publication in General Relativity and Gravitation. General Relativity and Gravitation in press (2010) 0

Circulating tumor DNA clearance predicts prognosis across treatment regimen in a large real-world longitudinally monitored advanced non-small cell lung cancer cohort

Background: Although growth advantage of certain clones would ultimately translate into a clinically visible disease progression, radiological imaging does not reflect clonal evolution at molecular level. Circulating tumor DNA (ctDNA), validated as a tool for mutation detection in lung cancer, could reflect dynamic molecular changes. We evaluated the utility of ctDNA as a predictive and a prognostic marker in disease monitoring of advanced non-small cell lung cancer (NSCLC) patients.Methods: This is a multicenter prospective cohort study. We performed capture-based ultra-deep sequencing on longitudinal plasma samples utilizing a panel consisting of 168 NSCLC-related genes on 949 advanced NSCLC patients with driver mutations to monitor treatment responses and disease progression. The correlations between ctDNA and progression-free survival (PFS)/overall survival (OS) were performed on 248 patients undergoing various treatments with the minimum of 2 ctDNA tests.Results: The results of this study revealed that higher ctDNA abundance (P=0.012) and mutation count (P=8.5x10(-4)) at baseline are associated with shorter OS. We also found that patients with ctDNA clearance, not just driver mutation clearance, at any point during the course of treatment were associated with longer PFS (P=2.2x10(-1)6, HR 0.28) and OS (P=4.5x10(-6), HR 0.19) regardless of type of treatment and evaluation schedule.Conclusions: This prospective real-world study shows that ctDNA clearance during treatment may serve as predictive and prognostic marker across a wide spectrum of treatment regimens