A phyto-guide to species selection for optimized South African green infrastructure

In South Africa, rapid environmental degeneration caused by anthropogenic pollution poses a major ecological engineering problem, demanding proper resource mitigation strategies. For the treatment of polluted water and degraded soil systems, green infrastructure (GI) offers an effective, sustainable and affordable nature-based alternative to grey infrastructure. An additive benefit within GI, plant species provide enormous potential to treatment; however, species vary substantially in their pollutant removal and hydrologic performance. South African civil engineers tasked with designing GI often lack expertise and knowledge of plant behaviour and ecosystem dynamics. Therefore, this paper proposes a decision framework to facilitate selection for designing local GI in the form of a phyto-guide, based on existing recommendations and knowledge of removal processes and plant behaviour. Interdisciplinarity at the core of the phyto-guide relies on continuous specialist collaboration with each selection criteria, whilst efficiency and sustainability are considered equally important contributors to successful GI functioning. The spread of invasive alien plants, whether accidental or deliberate, negatively impacts an ecosystem’s capacity to deliver goods and services. Thus, the desire to optimize GI by incorporating effective phytoremediators cannot be prioritised over conservation concerns. In addition, this paper seeks to advance the GI limitation of relying solely on previously identified phytoremediators, by including evaluation criteria of beneficial plant traits as well as plant distribution, behaviour and diversity into the decision-making process for optimized GI. It is recommended that future research engages in discovering less invasive, naturally occurring local species as potential phytoremediators, inspired by South Africa’s rich biodiversity and endemism, as well as conveying the importance of consultation with engineers and ecologists for optimized GI

The Chances to Produce and Detect the b-b-ubar-dbar Tetraquark at LHC

In the LHC collider a significant rate of events with double parton scattering is expected. This will be the leading mechanism for production of two b-bbar pairs. We estimate the probability of binding two b quarks into a diquark and the probability of dressing this diquark into a b-b-ubar-dbar ISP=01+ tetraquark. Calculations shows that that this bound state of two B mesons is stable against the strong interaction and has a life time of the order of ps. We estimate that the production rate at luminosity L=0.1 events per second will be about 6 tetraquarks per hour or more.Comment: Contributed talk at the XVIII European Conference on Few-Body Problems in Physics, September 8-14, Bled, Slovenia, 4 pages LaTe

Sub-Shot-Noise Quantum Optical Interferometry: A Comparison of Entangled State Performance within a Unified Measurement Scheme

Phase measurement using a lossless Mach-Zehnder interferometer with certain entangled $N$-photon states can lead to a phase sensitivity of the order of 1/N, the Heisenberg limit. However, previously considered output measurement schemes are different for different input states to achieve this limit. We show that it is possible to achieve this limit just by the parity measurement for all the commonly proposed entangled states. Based on the parity measurement scheme, the reductions of the phase sensitivity in the presence of photon loss are examined for the various input states.Comment: 5 pages, 2 figure

The Coulomb phase shift revisited

We investigate the Coulomb phase shift, and derive and analyze new and more precise analytical formulae. We consider next to leading order terms to the Stirling approximation, and show that they are important at small values of the angular momentum $l$ and other regimes. We employ the uniform approximation. The use of our expressions in low energy scattering of charged particles is discussed and some comparisons are made with other approximation methods.Comment: 13 pages, 5 figures, 1 tabl

An inhomogeneous toy-model of the quantum gravity with explicitly evolvable observables

An inhomogeneous (1+1)-dimensional model of the quantum gravity is considered. It is found, that this model corresponds to a string propagating against some curved background space. The quantization scheme including the Wheeler-DeWitt equation and the "particle on a sphere" type of the gauge condition is suggested. In the quantization scheme considered, the "problem of time" is solved by building of the quasi-Heisenberg operators acting in a space of solutions of the Wheeler-DeWitt equation and the normalization of the wave function corresponds to the Klein-Gordon type. To analyze the physical consequences of the scheme, a (1+1)-dimensional background space is considered for which a classical solution is found and quantized. The obtained estimations show the way to solution of the cosmological constant problem, which consists in compensation of the zero-point oscillations of the matter fields by the quantum oscillations of the scale factor. Along with such a compensation, a slow global evolution of a background corresponding to an universe expansion exists.Comment: 18 page

The Role of Extramembranous Cytoplasmic Termini in Assembly and Stability of the Tetrameric K+-Channel KcsA

Membrane-active alcohol 2,2,2-trifluoroethanol has been proven to be an attractive tool in the investigation of the intrinsic stability of integral membrane protein complexes by taking K+-channel KcsA as a suitable and representative ion channel. In the present study, the roles of both cytoplasmic N and C termini in channel assembly and stability of KcsA were determined. The N terminus (1–18 residues) slightly increased tetramer stability via electrostatic interactions in the presence of 30 mol.% acidic phosphatidylglycerol (PG) in phosphatidylcholine lipid bilayer. Furthermore, the N terminus was found to be potentially required for efficient channel (re)assembly. In contrast, truncation of the C terminus (125–160 residues) greatly facilitated channel reversibility from either a partially or a completely unfolded state, and this domain was substantially involved in stabilizing the tetramer in either the presence or absence of PG in lipid bilayer. These studies provide new insights into how extramembranous parts play their crucial roles in the assembly and stability of integral membrane protein complexes

De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis

This study investigated sonic hedgehog (Shh) signalling in gastric metaplasia in the insulin-gastrin (InsGas) hypergastrinaemic mouse +/− Helicobacter felis (H. felis) infection. Sonic hedgehog gene and protein expression was reduced in pre-metaplastic lesions from non-infected mice (90% gene reduction, P<0.01) compared to normal mucosa. Sonic hedgehog was reactivated in gastric metaplasia of H. felis-infected mice (3.5-fold increase, P<0.01) compared to pre-metaplastic lesions. Additionally, the Shh target gene, glioma-associated oncogene (Gli)-1, was significantly reduced in the gastric glands of InsGas mice (75% reduction, P<0.05) and reactivated with H. felis infection (P<0.05, base of glands, P<0.01 stroma of metaplastic glands). The ability of H. felis to activate the Shh pathway was investigated by measuring the effect of target cytokine, interleukin-8 (IL-8), on Shh expression in AGS and MGLVA1 cells, which was shown to induce Shh expression at physiological concentrations. H. felis induced the expression of NF-κB in inflammatory infiltrates in vivo, and the expression of the IL-8 mouse homologue, protein KC, in inflammatory infiltrates and metaplastic lesions. Sonic hedgehog pathway reactivation was paralleled with an increase in proliferation of metaplastic lesions (15.75 vs 4.39% in infected vs non-infected mice, respectively, P<0.001). Furthermore, Shh overexpression increased the growth rate of the gastric cancer cell line, AGS. The antiapoptotic protein, bcl-2, was expressed in the stroma of infected mice, along with a second Shh target gene, patched-1 (P=0.0001, stroma of metaplastic gland). This study provides evidence suggesting reactivation of Shh signalling from pre-metaplastic to advanced metaplastic lesions of the stomach and outlines the importance of the Shh pathway as a potential chemoprophylactic target for gastric carcinogenesis

Midlife diagnosis of Refsum Disease in siblings with Retinitis Pigmentosa – the footprint is the clue: a case report

<p>Abstract</p> <p>Introduction</p> <p>Refsum disease is a potentially lethal and disabling condition associated with retinitis pigmentosa in which early treatment can prevent some of the systemic manifestations.</p> <p>Case presentation</p> <p>We present the cases of two brothers with a diagnosis of retinitis pigmentosa from childhood in whom Refsum disease was subsequently diagnosed midlife, after routine enquiry into hand and feet abnormalities. Subsequent treatment through dietary modification stabilised visual impairment and has prevented development of neurological complications to date.</p> <p>Conclusion</p> <p>It is therefore important to consider the diagnosis of Refsum disease in any patient with autosomal recessive or simplex retinitis pigmentosa, and to enquire about the presence of "unusual" feet or hands in such patients.</p

R^4 counterterm and E7(7) symmetry in maximal supergravity

The coefficient of a potential R^4 counterterm in N=8 supergravity has been shown previously to vanish in an explicit three-loop calculation. The R^4 term respects N=8 supersymmetry; hence this result poses the question of whether another symmetry could be responsible for the cancellation of the three-loop divergence. In this article we investigate possible restrictions from the coset symmetry E7(7)/SU(8), exploring the limits as a single scalar becomes soft, as well as a double-soft scalar limit relation derived recently by Arkani-Hamed et al. We implement these relations for the matrix elements of the R^4 term that occurs in the low-energy expansion of closed-string tree-level amplitudes. We find that the matrix elements of R^4 that we investigated all obey the double-soft scalar limit relation, including certain non-maximally-helicity-violating six-point amplitudes. However, the single-soft limit does not vanish for this latter set of amplitudes, which suggests that the E7(7) symmetry is broken by the R^4 term.Comment: 33 pages, typos corrected, published versio