Entangled-State Cycles of Atomic Collective-Spin States

We study quantum trajectories of collective atomic spin states of $N$ effective two-level atoms driven with laser and cavity fields. We show that interesting ``entangled-state cycles'' arise probabilistically when the (Raman) transition rates between the two atomic levels are set equal. For odd (even) $N$, there are $(N+1)/2$ ($N/2$) possible cycles. During each cycle the $N$-qubit state switches, with each cavity photon emission, between the states $(|N/2,m>\pm |N/2,-m>)/\sqrt{2}$, where $|N/2,m>$ is a Dicke state in a rotated collective basis. The quantum number $m$ ($>0$), which distinguishes the particular cycle, is determined by the photon counting record and varies randomly from one trajectory to the next. For even $N$ it is also possible, under the same conditions, to prepare probabilistically (but in steady state) the Dicke state $|N/2,0>$, i.e., an $N$-qubit state with $N/2$ excitations, which is of particular interest in the context of multipartite entanglement.Comment: 10 pages, 9 figure

Supersymmetric States in Large N Chern-Simons-Matter Theories

In this paper we study the spectrum of BPS operators/states in N=2 superconformal U(N) Chern-Simons-matter theories with adjoint chiral matter fields, with and without superpotential. The superconformal indices and conjectures on the full supersymmetric spectrum of the theories in the large N limit with up to two adjoint matter fields are presented. Our results suggest that some of these theories may have supergravity duals at strong coupling, while some others may be dual to higher spin theories of gravity at strong coupling. For the N=2 theory with no superpotential, we study the renormalization of R-charge at finite 't Hooft coupling using "Z-minimization". A particularly intriguing result is found in the case of one adjoint matter.Comment: 53 pages, 18 figures. v2: improved numerics, additional comments adde

A New Weighted k-Nearest Neighbor Algorithm Based on Newton¿s Gravitational Force

[EN] The kNN algorithm has three main advantages that make it appealing to the community: it is easy to understand, it regularly offers competitive performance and its structure can be easily tuning to adapting to the needs of researchers to achieve better results. One of the variations is weighting the instances based on their distance. In this paper we propose a weighting based on the Newton's gravitational force, so that a mass (or relevance) has to be assigned to each instance. We evaluated this idea in the kNN context over 13 benchmark data sets used for binary and multi-class classification experiments. Results in F1 score, statistically validated, suggest that our proposal outperforms the original version of kNN and is statistically competitive with the distance weighted kNN version as well.This research was partially supported by CONACYT-Mexico (project FC-2410). The work of Paolo Rosso has been partially funded by the SomEMBED TIN2015-71147-C2-1-P MINECO research project.Aguilera, J.; González, LC.; Montes-Y-Gómez, M.; Rosso, P. (2019). A New Weighted k-Nearest Neighbor Algorithm Based on Newton¿s Gravitational Force. Lecture Notes in Computer Science. 11401:305-313. https://doi.org/10.1007/978-3-030-13469-3_36S3053131140

Refined Checks and Exact Dualities in Three Dimensions

We discuss and provide nontrivial evidence for a large class of dualities in three-dimensional field theories with different gauge groups. We match the full partition functions of the dual phases for any value of the couplings to underpin our proposals. We focus on two classes of models. The first class, motivated by the AdS/CFT conjecture, consists of necklace U(N) quiver gauge theories with non chiral matter fields. We also consider orientifold projections and establish dualities among necklace quivers with alternating orthogonal and symplectic groups. The second class consists of theories with tensor matter fields with free theory duals. In most of these cases the R-symmetry mixes with IR accidental symmetries and we develop the prescription to include their contribution into the partition function and the extremization problem accordingly.Comment: 38 pages, 3 figure, using jheppu

Precision Spectroscopy and Higher Spin symmetry in the ABJM model

We revisit Kaluza-Klein compactification of 11-d supergravity on S^7/Z_k using group theory techniques that may find application in other flux vacua with internal coset spaces. Among the SO(2) neutral states, we identify marginal deformations and fields that couple to the recently discussed world-sheet instanton of Type IIA on CP^3. We also discuss charged states, dual to monopole operators, and the Z_k projection of the Osp(4|8) singleton and its tensor products. In particular, we show that the doubleton spectrum may account for N=6 higher spin symmetry enhancement in the limit of vanishing 't Hooft coupling in the boundary Chern-Simons theory.Comment: 44 page

High energy emission from microquasars

The microquasar phenomenon is associated with the production of jets by X-ray binaries and, as such, may be associated with the majority of such systems. In this chapter we briefly outline the associations, definite, probable, possible, and speculative, between such jets and X-ray, gamma-ray and particle emission.Comment: Contributing chapter to the book Cosmic Gamma-Ray Sources, K.S. Cheng and G.E. Romero (eds.), to be published by Kluwer Academic Publishers, Dordrecht, 2004. (19 pages

Peripheral blood gene expression profiles in COPD subjects

To identify non-invasive gene expression markers for chronic obstructive pulmonary disease (COPD), we performed genome-wide expression profiling of peripheral blood samples from 12 subjects with significant airflow obstruction and an equal number of non-obstructed controls. RNA was isolated from Peripheral Blood Mononuclear Cells (PBMCs) and gene expression was assessed using Affymetrix U133 Plus 2.0 arrays.Tests for gene expression changes that discriminate between COPD cases (FEV1 80% predicted, FEV1/FVC > 0.7) were performed using Significance Analysis of Microarrays (SAM) and Bayesian Analysis of Differential Gene Expression (BADGE). Using either test at high stringency (SAM median FDR = 0 or BADGE p < 0.01) we identified differential expression for 45 known genes. Correlation of gene expression with lung function measurements (FEV1 & FEV1/FVC), using both Pearson and Spearman correlation coefficients (p < 0.05), identified a set of 86 genes. A total of 16 markers showed evidence of significant correlation (p < 0.05) with quantitative traits and differential expression between cases and controls. We further compared our peripheral gene expression markers with those we previously identified from lung tissue of the same cohort. Two genes, RP9and NAPE-PLD, were identified as decreased in COPD cases compared to controls in both lung tissue and blood. These results contribute to our understanding of gene expression changes in the peripheral blood of patients with COPD and may provide insight into potential mechanisms involved in the disease. © 2011 Bhattacharya et al; licensee BioMed Central Ltd

M5-branes from gauge theories on the 5-sphere

We use the 5-sphere partition functions of supersymmetric Yang-Mills theories to explore the (2,0) superconformal theory on S^5 x S^1. The 5d theories can be regarded as Scherk-Schwarz reductions of the 6d theory along the circle. In a special limit, the perturbative partition function takes the form of the Chern-Simons partition function on S^3. With a simple non-perturbative completion, it becomes a 6d index which captures the degeneracy of a sector of BPS states as well as the index version of the vacuum Casimir energy. The Casimir energy exhibits the N^3 scaling at large N. The large N index for U(N) gauge group also completely agrees with the supergravity index on AdS_7 x S^4.Comment: 44 pages, 1 figure, v4: ref added, clarified weak/strong coupling behaviors of large N free energy, minor improvements, version to be published in JHE

Identifying Ligand Binding Conformations of the β2-Adrenergic Receptor by Using Its Agonists as Computational Probes

Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that the difference between the effects of various agonists and antagonists cannot be explained by single structures alone, but rather that the conformational ensembles of the proteins need to be considered. Here we use an elastic network model-guided molecular dynamics simulation protocol to generate an ensemble of conformers of a prototypical GPCR, β2-adrenergic receptor (β2AR). The resulting conformers are clustered into groups based on the conformations of the ligand binding site, and distinct conformers from each group are assessed for their binding to known agonists of β2AR. We show that the select ligands bind preferentially to different predicted conformers of β2AR, and identify a role of β2AR extracellular region as an allosteric binding site for larger drugs such as salmeterol. Thus, drugs and ligands can be used as "computational probes" to systematically identify protein conformers with likely biological significance. © 2012 Isin et al

Serum-Dependent Selective Expression of EhTMKB1-9, a Member of Entamoeba histolytica B1 Family of Transmembrane Kinases

Entamoeba histolytica transmembrane kinases (EhTMKs) can be grouped into six distinct families on the basis of motifs and sequences. Analysis of the E. histolytica genome revealed the presence of 35 EhTMKB1 members on the basis of sequence identity (≥95%). Only six homologs were full length containing an extracellular domain, a transmembrane segment and an intracellular kinase domain. Reverse transcription followed by polymerase chain reaction (RT-PCR) of the kinase domain was used to generate a library of expressed sequences. Sequencing of randomly picked clones from this library revealed that about 95% of the clones were identical with a single member, EhTMKB1-9, in proliferating cells. On serum starvation, the relative number of EhTMKB1-9 derived sequences decreased with concomitant increase in the sequences derived from another member, EhTMKB1-18. The change in their relative expression was quantified by real time PCR. Northern analysis and RNase protection assay were used to study the temporal nature of EhTMKB1-9 expression after serum replenishment of starved cells. The results showed that the expression of EhTMKB1-9 was sinusoidal. Specific transcriptional induction of EhTMKB1-9 upon serum replenishment was further confirmed by reporter gene (luciferase) expression and the upstream sequence responsible for serum responsiveness was identified. EhTMKB1-9 is one of the first examples of an inducible gene in Entamoeba. The protein encoded by this member was functionally characterized. The recombinant kinase domain of EhTMKB1-9 displayed protein kinase activity. It is likely to have dual specificity as judged from its sensitivity to different kinase inhibitors. Immuno-localization showed EhTMKB1-9 to be a surface protein which decreased on serum starvation and got relocalized on serum replenishment. Cell lines expressing either EhTMKB1-9 without kinase domain, or EhTMKB1-9 antisense RNA, showed decreased cellular proliferation and target cell killing. Our results suggest that E. histolytica TMKs of B1 family are functional kinases likely to be involved in serum response and cellular proliferation