A study of the new X-ray transient RXTE J2123-058 during its post-outburst state

We carried out I, R, V and B photometric observations of the neutron star X-ray binary RXTE J2123−058 shortly after the end of the X-ray outburst in mid-1998. We adopt the low-mass binary model to interpret our observations. After folding our data on the 0.24 821-d orbital period, and correcting for the steady brightness decline following the outburst, we observed sinusoidal oscillations with hints of ellipsoidal modulations which became progressively more evident. Our data also show that the decline in brightness was faster in the V band than in the R and I bands. This suggests both the cooling of an irradiation-heated secondary star and the fading of an accretion disc over the nights of our observations

Diabetes mellitus and hearing loss: A review

Diabetes (type 2) and sensorineural hearing loss are common health problems manifested with ageing. While both type 1 and type 2 diabetes have been associated with hearing loss, a causal link has been difficult to establish. Individuals with diabetes have twice the incidence of hearing loss compared to those without diabetes and those with prediabetes have a 30% higher rate of hearing loss. Whether hearing loss is associated with diabetes independent of glycemic control remains to be determined. Hearing loss has its own set of risk factors and shares others with diabetes. This review will summarize the complex relationship between diabetes and sensorineural hearing loss

Detection of ipsilateral and contralateral activation components in unilateral fingers-tapping using spinal BOLD fMR

Ipsilateral activation component has been reported in brain fMRI studies using unilateral finger motion. However, the ipsilateral component is usually taskdependent and sparsely distributed. In this study, spinal BOLD fMRI has been performed on 4 healthy right-handed volunteers performing unilateral fingerstapping to investigate the ipsilateral and contralateral activation inside the cervical spinal cord. Our results showed that more activation were found at the spinal level C5-C6/C7. Bilateral activation was observed in all subjects both in left/right hand fingers-tapping. Spinal fMRI was sensitive to detect bilateral firing in fingers-tapping using dominant or non-dominant hands.published_or_final_versio

Catalytic steam gasification of biomass for a sustainable hydrogen future: influence of catalyst composition

Hydrogen is regarded as a clean energy for fuelling the future. Hydrogen will be the energy carrier from other resources such as hydropower, wind, solar and biomass. Producing hydrogen from gasification of biomass wastes, particularly in the presence of steam, represents a promising route to produce this clean and CO2-neutral fuel. The steam pyrolysis-gasification ofbiomass (wood sawdust) was carried out with various nickel-based catalysts for hydrogen production in a two-stage fixed bed reaction system. The wood sawdust was pyrolysed in the first reactor and the derived products were gasified in the second reactor in the presence of the catalyst and steam. The synthesised Ni-Ca-Al and Ni-Zn-Al catalysts were preparedbyco-precipitation method with different Ni loadings of 20 mol% and various Zn/Al or Ca/Al ratios, which were characterized with scanning electron microscopy (SEM), transmission electron microscopy (TEM) and temperature-programmed oxidation (TPO). The results showed that the Ni/Zn-Al (1:9) catalyst resulted in higher hydrogenproduction(23.9 mmol H2 g-1biomass)compared with the Ni/Ca-Al (1:9) catalyst (12.7 23.9 mmol H2 g-1 biomass) and in addition, the increase of Ca or Zn content in the catalyst slightly increased the hydrogen production. The TPO results showed that the catalyst suffered negligible coke deposition from the catalytic steam pyrolysis/gasification of wood sawdust. Additionally, Na2CO3 basic solution was also found toproduce a catalyst with better performance and lower coke deposition, compared with NH4OH catalyst preparation agent, as observed by TPO, SEM and TEM analysis

Melatonin Alters Age-Related Changes in Transcription Factors and Kinase Activation

Male mice were fed 40 ppm melatonin for 2 months prior to sacrifice at age 26 months, and compared with both 26 and 4 month-old untreated controls. The nuclear translocation of NF-κB increased with age in both brain and spleen and this was reversed by melatonin only in brain. Another transcription factor, AP-1 was increased with age in the spleen and not in brain and this could be blocked by melatonin treatment. The fraction of the active relative to the inactive form of several enabling kinases was compared. The proportion of activated ERK was elevated with age in brain and spleen but this change was unresponsive to melatonin. A similar age-related increase in glial fibrillary acidic protein (GFAP) was also refractory to melatonin treatment. The cerebral melatonin M1 receptor decreased with age in brain but increased in spleen. The potentially beneficial nature of melatonin for the preservation of brain function with aging was suggested by the finding that an age-related decline in cortical synaptophysin levels was prevented by dietary melatonin

Changes in BMI before and during economic development and subsequent risk of cardiovascular disease and total mortality: A 35-year follow-up study in China

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Structure of the hDmc1-ssDNA filament reveals the principles of its architecture

In eukaryotes, meiotic recombination is a major source of genetic diversity, but its defects in humans lead to abnormalities such as Down's, Klinefelter's and other syndromes. Human Dmc1 (hDmc1), a RecA/Rad51 homologue, is a recombinase that plays a crucial role in faithful chromosome segregation during meiosis. The initial step of homologous recombination occurs when hDmc1 forms a filament on single-stranded (ss) DNA. However the structure of this presynaptic complex filament for hDmc1 remains unknown. To compare hDmc1-ssDNA complexes to those known for the RecA/Rad51 family we have obtained electron microscopy (EM) structures of hDmc1-ssDNA nucleoprotein filaments using single particle approach. The EM maps were analysed by docking crystal structures of Dmc1, Rad51, RadA, RecA and DNA. To fully characterise hDmc1-DNA complexes we have analysed their organisation in the presence of Ca2+, Mg2+, ATP, AMP-PNP, ssDNA and dsDNA. The 3D EM structures of the hDmc1-ssDNA filaments allowed us to elucidate the principles of their internal architecture. Similar to the RecA/Rad51 family, hDmc1 forms helical filaments on ssDNA in two states: extended (active) and compressed (inactive). However, in contrast to the RecA/Rad51 family, and the recently reported structure of hDmc1-double stranded (ds) DNA nucleoprotein filaments, the extended (active) state of the hDmc1 filament formed on ssDNA has nine protomers per helical turn, instead of the conventional six, resulting in one protomer covering two nucleotides instead of three. The control reconstruction of the hDmc1-dsDNA filament revealed 6.4 protein subunits per helical turn indicating that the filament organisation varies depending on the DNA templates. Our structural analysis has also revealed that the N-terminal domain of hDmc1 accomplishes its important role in complex formation through domain swapping between adjacent protomers, thus providing a mechanistic basis for coordinated action of hDmc1 protomers during meiotic recombination

Generation of fusion protein EGFRvIII-HBcAg and its anti-tumor effect in vivo

The epidermal growth factor receptor variant III (EGFRvIII) is the most common variation of EGFR. Because it shows a high frequency in several different types of tumor and has not been detected in normal tissues, it is an ideal target for tumor specific therapy. In this study, we prepared EGFRvIII-HBcAg fusion protein. After immunization with fusion protein, HBcAg or PBS, the titers of antibody in BALB/c mice immunized with fusion protein reached 2.75 × 105. Western blot analysis demonstrated that the fusion protein had specific antigenicity against anti-EGFRvIII antibody. Further observation showed fusion protein induced a high frequency of IFN-γ-secreting lymphocytes. CD4+T cells rather than CD8+T cells were associated with the production of IFN-γ. Using Renca-vIII(+) cell as specific stimulator, we observed remarkable cytotoxic activity in splenocytes from mice immunized with fusion protein. Mice were challenged with Renca-vIII(+) cells after five times immunization. In fusion protein group, three of ten mice failed to develop tumor and all survived at the end of the research. The weight of tumors in fusion protein were obviously lighter than that in other two groups (t = 4.73, P = 0.044;t = 6.89, P = 0.040). These findings demonstrated that EGFRvIII-HBcAg fusion protein triggered protective responses against tumor expressing EGFRvIII

Facile Synthesis of Three-Dimensional ZnO Nanostructure: Realization of a Multifunctional Stable Superhydrophobic Surface

BACKGROUND: After comprehensive study of various superhydrophobic phenomena in nature, it is no longer a puzzle for researchers to realize such fetching surfaces. However, the different types of artificial surfaces may get wetted and lose its water repellence if there exist defects or the liquid is under pressure. With respect to the industry applications, in which the resistance of wetting transition is critical important, new nanostructure satisfied a certain geometric criterion should be designed to hold a stable gas film at the base area to avoid the wet transition. METHODOLOGY: A thermal deposition method was utilized to produce a thin ZnO seeds membrane on the aluminum foil. And then a chemical self-assemble technology was developed in present work to fabricate three-dimensional (3D) hierarchical dune-like ZnO architecture based on the prepared seeds membrane. RESULTS: Hierarchical ZnO with micro scale dune-like structure and core-sharing nanosheets was generated. The characterization results showed that there exist plenty of gaps and interfaces among the micro-dune and nanosheets, and thus the surface area was enlarged by such a unique morphology. Benefited from this unique 3D ZnO hierarchical nanostructure, the obtained surface exhibited stable water repellency after modification with Teflon, and furthermore, based on solid theory analysis, such 3D ZnO nanostructure would exhibit excellent sensing performance