38 research outputs found
Predicting site index from climate and soil variables for cork oak (Quercus suber L.) stands in Portugal
Site productivity, assessed through site index, was modelled using partial least
squares regression as a function of soil and climatic variables. Two alternative models were
developed: a full model, considering all available explanatory variables, and a reduced
model, considering only variables that can be obtained without digging a soil pit. The
reduced model was used for mapping the site index distribution in Portugal, on the basis of
existing digital cartography available for the whole country. The developed models indicate
the importance of water availability and soil water holding capacity for site index
value distribution. Site index was related to climate, namely evaporation and frost, and soil
characteristics such as lithology, soil texture, soil depth, thickness of the A horizon and soil
classification. The variability of the estimated values within the map (9.5–16.8 m with an
average value of 13.4 m) reflects the impact of soil characteristics on the site productivity
estimation. These variables should be taken into consideration during the establishment of
new plantations of cork oak, and management of existing plantations. Results confirm the
potential distribution of cork oak in coastal regions. They also suggest the existence of a
considerable area, located both North and South of the Tagus river, where site indices
values of medium (]13;15]) to high (]15;17]) productivity classes may be expected. The
species is then expected to be able to have good productivity along the northern coastal
areas of Portugal, where presently it is not a common species but where, according to
historical records, it occurred until the middle of the sixteenth century. The present
research focused on tree growth. Cork growth and cork quality distribution needs to be
further researched through the establishment of long term experimental sites along the distribution area of cork oak, namely in the central and northern coastal areas of the
countryinfo:eu-repo/semantics/publishedVersio
DFT-inspired methods for quantum thermodynamics
In the framework of quantum thermodynamics, we propose a method to
quantitatively describe thermodynamic quantities for out-of-equilibrium
interacting many-body systems. The method is articulated in various
approximation protocols which allow to achieve increasing levels of accuracy,
it is relatively simple to implement even for medium and large number of
interactive particles, and uses tools and concepts from density functional
theory. We test the method on the driven Hubbard dimer at half filling, and
compare exact and approximate results. We show that the proposed method
reproduces the average quantum work to high accuracy: for a very large region
of parameter space (which cuts across all dynamical regimes) estimates are
within 10% of the exact results
The Prometastatic Microenvironment of the Liver
The liver is a major metastasis-susceptible site and majority of patients with hepatic metastasis die from the disease in the absence of efficient treatments. The intrahepatic circulation and microvascular arrest of cancer cells trigger a local inflammatory reaction leading to cancer cell apoptosis and cytotoxicity via oxidative stress mediators (mainly nitric oxide and hydrogen peroxide) and hepatic natural killer cells. However, certain cancer cells that resist or even deactivate these anti-tumoral defense mechanisms still can adhere to endothelial cells of the hepatic microvasculature through proinflammatory cytokine-mediated mechanisms. During their temporary residence, some of these cancer cells ignore growth-inhibitory factors while respond to proliferation-stimulating factors released from tumor-activated hepatocytes and sinusoidal cells. This leads to avascular micrometastasis generation in periportal areas of hepatic lobules. Hepatocytes and myofibroblasts derived from portal tracts and activated hepatic stellate cells are next recruited into some of these avascular micrometastases. These create a private microenvironment that supports their development through the specific release of both proangiogenic factors and cancer cell invasion- and proliferation-stimulating factors. Moreover, both soluble factors from tumor-activated hepatocytes and myofibroblasts also contribute to the regulation of metastatic cancer cell genes. Therefore, the liver offers a prometastatic microenvironment to circulating cancer cells that supports metastasis development. The ability to resist anti-tumor hepatic defense and to take advantage of hepatic cell-derived factors are key phenotypic properties of liver-metastasizing cancer cells. Knowledge on hepatic metastasis regulation by microenvironment opens multiple opportunities for metastasis inhibition at both subclinical and advanced stages. In addition, together with metastasis-related gene profiles revealing the existence of liver metastasis potential in primary tumors, new biomarkers on the prometastatic microenvironment of the liver may be helpful for the individual assessment of hepatic metastasis risk in cancer patients
Lyme disease risk in southern California: abiotic and environmental drivers of Ixodes pacificus (Acari: Ixodidae) density and infection prevalence with Borrelia burgdorferi
Oxidative Stress in Wild Boars Naturally and Experimentally Infected with Mycobacterium bovis
Reactive oxygen and nitrogen species (ROS-RNS) are important defence substances involved in the immune response against pathogens. An excessive increase in ROS-RNS, however, can damage the organism causing oxidative stress (OS). The organism is able to neutralise OS by the production of antioxidant enzymes (AE); hence, tissue damage is the result of an imbalance between oxidant and antioxidant status. Though some work has been carried out in humans, there is a lack of information about the oxidant/antioxidant status in the presence of tuberculosis (TB) in wild reservoirs. In the Mediterranean Basin, wild boar (Sus scrofa) is the main reservoir of TB. Wild boar showing severe TB have an increased risk to Mycobacterium spp. shedding, leading to pathogen spreading and persistence. If OS is greater in these individuals, oxidant/antioxidant balance in TB-affected boars could be used as a biomarker of disease severity. The present work had a two-fold objective: i) to study the effects of bovine TB on different OS biomarkers (namely superoxide dismutase (SOD), catalasa (CAT), glutathione peroxidase (GPX), glutathione reductase (GR) and thiobarbituric acid reactive substances (TBARS)) in wild boar experimentally challenged with Mycobacterium bovis, and ii) to explore the role of body weight, sex, population and season in explaining the observed variability of OS indicators in two populations of free-ranging wild boar where TB is common. For the first objective, a partial least squares regression (PLSR) approach was used whereas, recursive partitioning with regression tree models (RTM) were applied for the second. A negative relationship between antioxidant enzymes and bovine TB (the more severe lesions, the lower the concentration of antioxidant biomarkers) was observed in experimentally infected animals. The final PLSR model retained the GPX, SOD and GR biomarkers and showed that 17.6% of the observed variability of antioxidant capacity was significantly correlated with the PLSR X's component represented by both disease status and the age of boars. In the samples from free-ranging wild boar, however, the environmental factors were more relevant to the observed variability of the OS biomarkers than the TB itself. For each OS biomarker, each RTM was defined as a maximum by one node due to the population effect. Along the same lines, the ad hoc tree regression on boars from the population with a higher prevalence of severe TB confirmed that disease status was not the main factor explaining the observed variability in OS biomarkers. It was concluded that oxidative damage caused by TB is significant, but can only be detected in the absence of environmental variation in wild boar
α-Aminophosphonate Derivatives for Enhanced Flame Retardant Properties in Epoxy Resin
This work demonstrates the introduction of various α-aminophosphonate compounds to an epoxy resin system, thereby improving flame retardance properties. The α-aminophosphonate scaffold allows for covalent incorporation (via the secondary amine) of the compounds into the polymer network. This work explores the synergistic effect of phosphorus and halogens (such as fluorine) to improve flame retardancy. The compounds were all prepared and isolated in analytical purity and in good yield (95%). Epoxy samples were prepared, individually incorporating each compound. Thermogravimetric analysis showed an increased char yield, indicating an improved thermal resistance (with respect to the control sample). Limiting oxygen index for the control polymer was 28.0% ± 0.31% and it increased to 34.6% ± 0.33% for the fluorinated derivativ