606 research outputs found
Study of Multiparticle Spikes in Central 4.5A GeV/c C-Cu Collisions
An analysis of local fluctuations, or spikes, is performed for charged
particles produced in central C-Cu collisions at 4.5 GeV//nucleon. The
distributions of spike-centers and the maximum density distributions are
investigated for different narrow pseudorapidity windows to search for
multiparticle dynamical correlations. Two peaks over statistical background are
observed in the spike-center distributions with the structure similar to that
expected from the coherent gluon radiation model and recently found in hadronic
interactions. The dynamical contribution to maximum density fluctuations are
obtained to be hidden by statistical correlations, though behavior of the
distributions shows qualitative agreement with that from the one-dimensional
intermittency model. The observed features of the two different approaches,
coherent vs. stochastic, to the formation of the local dynamical fluctuations
are discussed.Comment: 12 pages, LaTeX, 2 eps fig
Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities
E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success. The von Hippel-Lindau protein (pVHL) is the substrate recognition subunit of the VHL E3 ligase that targets HIF-1α for degradation. We recently reported inhibitors of the pVHL:HIF-1α interaction, however they exhibited moderate potency. Herein, we report the design and optimization, guided by X-ray crystal structures, of a ligand series with nanomolar binding affinities
Hospedabilidade de plantas melhoradoras de solo Ă Rotylenchulus reniformis Linford e Oliveira (1940)
The ÎŽN formula is the dynamical renormalization group
We derive the 'separate universe' method for the inflationary bispectrum,
beginning directly from a field-theory calculation. We work to tree-level in
quantum effects but to all orders in the slow-roll expansion, with masses
accommodated perturbatively. Our method provides a systematic basis to account
for novel sources of time-dependence in inflationary correlation functions, and
has immediate applications. First, we use our result to obtain the correct
matching prescription between the 'quantum' and 'classical' parts of the
separate universe computation. Second, we elaborate on the application of this
method in situations where its validity is not clear. As a by-product of our
calculation we give the leading slow-roll corrections to the three-point
function of field fluctuations on spatially flat hypersurfaces in a canonical,
multiple-field model.Comment: v1: 33 pages, plus appendix and references; 5 figures. v2:
typographical typos fixed, minor changes to the main text and abstract,
reference added; matches version published in JCA
Dynamics of coupled cell networks: synchrony, heteroclinic cycles and inflation
Copyright © 2011 Springer. The final publication is available at www.springerlink.comWe consider the dynamics of small networks of coupled cells. We usually assume asymmetric inputs and no global or local symmetries in the network and consider equivalence of networks in this setting; that is, when two networks with different architectures give rise to the same set of possible dynamics. Focussing on transitive (strongly connected) networks that have only one type of cell (identical cell networks) we address three questions relating the network structure to dynamics. The first question is how the structure of the network may force the existence of invariant subspaces (synchrony subspaces). The second question is how these invariant subspaces can support robust heteroclinic attractors. Finally, we investigate how the dynamics of coupled cell networks with different structures and numbers of cells can be related; in particular we consider the sets of possible âinflationsâ of a coupled cell network that are obtained by replacing one cell by many of the same type, in such a way that the original network dynamics is still present within a synchrony subspace. We illustrate the results with a number of examples of networks of up to six cells
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