The Transversity Function and Double Spin Azimuthal Asymmetry in Semi-Inclusive Pion Leptoproduction

We show that the transverse momentum dependent transversity function is proportional to the longitudinal polarization of a quark in a transversely polarized proton. This result suggests an alternative, convenient method for determining transversity, without knowing unusual fragmentation functions. The method consists of measuring the double spin azimuthal asymmetry in semi-inclusive pion leptoproduction by a transversely polarized proton target. The asymmetry, which is twist 3, is estimated to be more than 10% under the most favorable conditions. The experiment we suggest is feasible at facilities like DESY and CERN.Comment: extended version; to appear on Int. Jou. Mod. Phys.

X-ray spectral evolution of the extragalactic Z-source, LMC X-2

We present the results obtained by a detailed study of the extragalactic Z source, LMC X-2, using broad band Suzaku data and a large ($\sim 750$ ksec) data set obtained with the proportional counter array (PCA) onboard RXTE. The PCA data allows for studying the complete spectral evolution along the horizontal, normal and flaring branches of the Z-track. Comparison with previous study show that the details of spectral evolution (like variation of Comptonizing electron temperature), is similar to that of GX 17+2 but unlike that of Cyg X-2 and GX 349+2. This suggests that Z sources are heterogeneous group with perhaps LMC X-2 and GX 17+2 being member of a subclass. However non monotonic evolution of the Compton y-parameter seems to be generic to all sources. The broad band {\it Suzaku} data reveals that the additional soft component of the source modelled as a disk blackbody emission is strongly preferred over one where it is taken to be a blackbody spectrum. This component as well as the temperature of seed photons do not vary when source goes into a flaring mode and the entire variation can be ascribed to the Comptonizing cloud. The bolometric unabsorbed luminosity of the source is well constrained to be $\sim 2.23 \times 10^{38}$ ergs/sec which if the source is Eddington limited implies a neutron star mass of 1.6 M$_\odot$. We discuss the implications of these results.Comment: 9 pages, 8 figures, accepted for the publicatin in MNRA

Evidence for a resonant cyclotron line in IGR J16493-4348 from the Swift-BAT hard X-ray survey

Resonant absorption cyclotron features are a key diagnostic tool to directly measure the strength of the magnetic field of accreting neutron stars. However, typical values for cyclotron features lie in the high-energy part of the spectrum between 20 keV and 50 keV, where detection is often damped by the low statistics from single pointed observations. We show that long-term monitoring campaign performed with Swift-BAT of persistently, but faint, accreting high-mass X-ray binaries is able to reveal in their spectra the presence of cyclotron features. We extracted the average Swift-BAT 15-150 keV spectrum from the 54 months long Swift-BAT survey of the high-mass X-ray source IGR J16493-4348. To constrain the broadband spectrum we used soft X-ray spectra from Swift-XRT and Suzaku pointed observations. We model the spectra using a set of phenomenological models usually adopted to describe the energy spectrum of accreting high-mass X-ray binaries; irrespective of the models we used, we found significant improvements in the spectral fits adding to the models a broad (10 keV width) absorption feature, with best-fitting energy estimate between 30 and 33 keV, that we interpret as evidence for a resonant cyclotron absorption feature. We also discuss instrumental issues related to the use of Swift-BAT for this kind of studies and the statistical method to weight the confidence level of this detection. Correcting for the gravitational redshift of a 1.4 M_{\sun} neutron star, the inferred surface magnetic field is Bsurf 3.7 x 10^{12} Gauss. The spectral parameters of IGR J16493-4348 fit well with empirical correlations observed when the whole sample of high-mass binaries with detected cyclotron features is considered.Comment: Published in Astronomy & Astrophysics, 2011, 532, A7

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs

The multifaceted role of vitamin b6 in cancer: drosophila as a model system to investigate dna damage

A perturbed uptake of micronutrients, such as minerals and vitamins, impacts on different human diseases, including cancer and neurological disorders. Several data converge towards a crucial role played by many micronutrients in genome integrity maintenance and in the establishment of a correct DNA methylation pattern. Failure in the proper accomplishment of these processes accelerates senescence and increases the risk of developing cancer, by promoting the formation of chromosome aberrations and deregulating the expression of oncogenes. Here, the main recent evidence regarding the impact of some B vitamins on DNA damage and cancer is summarized, providing an integrated and updated analysis, mainly centred on vitamin B6. In many cases, it is difficult to finely predict the optimal vitamin rate that is able to protect against DNA damage, as this can be influenced by a given individual's genotype. For this purpose, a precious resort is represented by model organisms which allow limitations imposed by more complex systems to be overcome. In this review, we show that Drosophila can be a useful model to deeply understand mechanisms underlying the relationship between vitamin B6 and genome integrity

Interpreting physical performance in professional soccer match-play: Should we be more pragmatic in our approach?

Academic and practitioner interest in the physical performance of male professional soccer players in the competition setting determined via time-motion analyses has grown substantially over the last four decades leading to a substantial body of published research and aiding development of a more systematic evidence-based framework for physical conditioning. Findings have forcibly shaped contemporary opinions in the sport with researchers and practitioners frequently emphasising the important role that physical performance plays in match outcomes. Time-motion analyses have also influenced practice as player conditioning programmes can be tailored according to the different physical demands identified across individual playing positions. Yet despite a more systematic approach to physical conditioning, data indicate that even at the very highest standards of competition, the contemporary player is still susceptible to transient and end-game fatigue. Over the course of this article, the author suggests that a more pragmatic approach to interpreting the current body of time-motion analysis data and its application in the practical setting is nevertheless required. Examples of this are addressed using findings in the literature to examine: a) the association between competitive physical performance and ‘success’ in professional soccer, b) current approaches to interpreting differences in time-motion analysis data across playing positions and, c) whether data can realistically be used to demonstrate the occurrence of fatigue in match-play. Gaps in the current literature and directions for future research are also identified

The near-IR counterpart of IGR J17480-2446 in Terzan 5

Some globular clusters in our Galaxy are noticeably rich in low-mass X-ray binaries. Terzan 5 has the richest population among globular clusters of X- and radio-pulsars and low-mass X-ray binaries. The detection and study of optical/IR counterparts of low-mass X-ray binaries is fundamental to characterizing both the low-mass donor in the binary system and investigating the mechanisms of the formation and evolution of this class of objects. We aim at identifying the near-IR counterpart of the 11 Hz pulsar IGRJ17480-2446 discovered in Terzan 5. Adaptive optics (AO) systems represent the only possibility for studying the very dense environment of GC cores from the ground. We carried out observations of the core of Terzan 5 in the near-IR bands with the ESO-VLT NAOS-CONICA instrument. We present the discovery of the likely counterpart in the Ks band and discuss its properties both in outburst and in quiescence. Archival HST observations are used to extend our discussion to the optical bands. The source is located at the blue edge of the turn-off area in the color-magnitude diagram of the cluster. Its luminosity increase from quiescence to outburst, by a factor 2.5, allows us to discuss the nature of the donor star in the context of the double stellar generation population of Terzan 5 by using recent stellar evolution models.Comment: 7 pages, 4 figure

Molecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy

Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5′-phosphate oxidase deficiency (PNPOD; OMIM: 610090), an autosomal recessive inborn error of metabolism that usually manifests with neonatal-onset severe seizures and subsequent encephalopathy. At present, 27 pathogenic mutations of the gene encoding human PNPO are known, 13 of which are homozygous missense mutations; however, only 3 of them have been characterised with respect to the molecular and functional properties of the variant enzyme forms. Moreover, studies on wild type and variant human PNPOs have so far largely ignored the regulation properties of this enzyme. Here, we present a detailed characterisation of the inhibition mechanism of PNPO by pyridoxal 5′-phosphate (PLP), the reaction product of the enzyme. Our study reveals that human PNPO has an allosteric PLP binding site that plays a crucial role in the enzyme regulation and therefore in the regulation of vitamin B6 metabolism in humans. Furthermore, we have produced, recombinantly expressed and characterised several PNPO pathogenic variants responsible for PNPOD (G118R, R141C, R225H, R116Q/R225H, and X262Q). Such replacements mainly affect the catalytic activity of PNPO and binding of the enzyme substrate and FMN cofactor, leaving the allosteric properties unaltered