Groundwater monitoring at a building site of the tidal flood protection system “MOSE” in the Lagoon of Venice, Italy

To protect Venice against tidal flooding, the MOSE system (Experimental Electro-mechanic Module) has been under construction since 2003. This safeguarding system is composed of four batteries of mobile barriers at the Lagoon’s inlets (Lido, Malamocco, Chioggia), which will be lifted before the occurrence of exceptional high tides (>1.10 m above the mean sea level), isolating the Venetian Lagoon from the sea. The end of the construction work is foreseen by 2016. In this paper, the results of the groundwater monitoring at the building site of Punta Sabbioni at the Lido inlet are described. A large dewatered basin (tura), formerly occupied by the sea and close to the shoreline, was used for the precasting of the mobile barriers, and the impact of groundwater control was therefore monitored in the phreatic and shallow confined aquifers. Although a slurry wall barrier was excavated to isolate the tura, a drawdown cone in the confined aquifer was observed, extending to 1 km from the construction site. In contrast, the phreatic aquifer was only influenced by tides, rainfall and evapotranspiration, and the slurry wall of the tura had a positive effect of decreasing the groundwater salinity by limiting the seawater intrusion, as confirmed by the electrical conductivity profiles measured inside the piezometers. The monitoring activity was successful in assessing the impacts of the construction work on the aquifer system and in distinguishing them from the effects of natural driving forces

investigation of bearings overloads due to misaligned splined shafts

Abstract Bearings may be subjected to overloads due to shaft unwanted loads, caused, as an example, by tiling moments related to spline coupling misalignment. Misalignment is mainly generated by manufacturing of mounting errors (due to machining tolerances) or by the transmission working conditions. These kind of overload is critical because may reduce both bearing life and system efficiency, moreover it is quite complicated to be evaluated. In this work, the overload generated on bearings supporting a misaligned splined shafts have been investigated by means of a commercial simulation software (Romax Designer). The simulations have been performed considering a standard transmission scheme composed of two shafts connected by a spline coupling and supported by four roller bearings (two for each shaft), mounted in isostatic configuration. The effect of spline coupling teeth microgeometry has been taken into account along with the misalignment angle magnitude and the torque level. In particular, the influence of these parameters on teeth contact pressure has been evaluated, as tilting moment is mainly driven by the contact pressure distribution among engaging teeth and by the position of maximum pressure distribution along teeth in axial direction. Results obtained in this work may be useful to designers, suggesting some basic criteria to reduce the bearings overload, allowing designing more reliable and efficient machines

VAD in failing Fontan: simulation of ventricular, cavo-pulmonary and biventricular assistance in systolic/diastolic ventricular dysfunction and in pulmonary vascular resistance increase.

Aim: Due to the lack of donors, VADs could be an alternative to heart transplantation for Failing Fontan patients (PTs). Considering the complex physiopathology and the type of VAD connection, a numerical model (NM) could be useful to support clinical decisions. The aim of this work is to test a NM simulating the VADs effects on failing Fontan for systolic dysfunction (SD), diastolic dysfunction (DD) and pulmonary vascular resistance increase (PRI). Methods: Data of 10 Fontan PTs were used to simulate the PTs baseline using a dedicated NM. Then, for each PTs a SD, a DD and a PRI were simulated. Finally, for each PT and for each pathology, the VADs implantation was simulated. Results: NM can well reproduce PTs baseline. In the case of SD, LVAD increases the cardiac output (CO) (35%) and the arterial systemic pressure (ASP) (25%). With cavo-pulmonary assistance (RVAD) a decrease of inferior vena cava pressure (IVCP) (39%) was observed with 34% increase of CO. With the BIVAD an increase of ASP (29%) and CO (37%) was observed. In the case of DD, the LVAD increases CO (42%), the RVAD decreases the IVCP. In the case of PRI, the highest CO (50%) and ASP (28%) increase is obtained with an RVAD together with the highest decrease of IVCP (53%). Conclusions: The use of NM could be helpful in this innovative field to evaluate the VADs implantation effects on specific PT to support PT and VAD selection

A Sterescopic System to Measure Water Waves in Laboratories

A new system for estimating the synthetic parameters of sea states during physical investigations has been implemented. The technique proposed herein is based on stereographic analysis of digital images acquired with optical sensors. A series of ad hoc floating markers has been made and properly moored to the bottom of a large wave tank to estimate the synthetic parameters of generated waves. The implemented acquisition system and the proposed algorithm provide automatic recognition of all markers by a pair of optical sensors that synchronously captures their instantaneous location and tracks their movements over time. After transformation from the image to the real-world coordinates, water surface elevation time series have been obtained. Several experimental tests have been carried out to assess the feasibility and reliability of the proposed approach. The estimated wave synthetic parameters have been then compared with those obtained by employing standard resistive probes. The deviation were found to be equal to ~6% for the significant wave height and 1% for peak, mean, and significant wave periods

Refinement of the diagnostic approach for the identification of children and adolescents affected by familial hypercholesterolemia: Evidence from the LIPIGEN study

Background and aims: We aimed to describe the limitations of familiar hypercholesterolemia (FH) diagnosis in childhood based on the presence of the typical features of FH, such as physical sings of cholesterol accumulation and personal or family history of premature cardiovascular disease or hypercholesterolemia, comparing their prevalence in the adult and paediatric FH population, and to illustrate how additional information can lead to a more effective diagnosis of FH at a younger age.Methods: From the Italian LIPIGEN cohort, we selected 1188 (>= 18 years) and 708 (<18 years) genetically-confirmed heterozygous FH, with no missing personal FH features. The prevalence of personal and familial FH features was compared between the two groups. For a sub-group of the paediatric cohort (N = 374), data about premature coronary heart disease (CHD) in second-degree family members were also included in the evaluation.Results: The lower prevalence of typical FH features in children/adolescents vs adults was confirmed: the prevalence of tendon xanthoma was 2.1% vs 13.1%, and arcus cornealis was present in 1.6% vs 11.2% of the cohorts, respectively. No children presented clinical history of premature CHD or cerebral/peripheral vascular disease compared to 8.8% and 5.6% of adults, respectively. The prevalence of premature CHD in first-degree relatives was significantly higher in adults compared to children/adolescents (38.9% vs 19.7%). In the sub-cohort analysis, a premature CHD event in parents was reported in 63 out of 374 subjects (16.8%), but the percentage increased to 54.0% extending the evaluation also to second-degree relatives.Conclusions: In children, the typical FH features are clearly less informative than in adults. A more thorough data collection, adding information about second-degree relatives, could improve the diagnosis of FH at younger age

Lipoprotein(a) Genotype Influences the Clinical Diagnosis of Familial Hypercholesterolemia

: Background Evidence suggests that LPA risk genotypes are a possible contributor to the clinical diagnosis of familial hypercholesterolemia (FH). This study aimed at determining the prevalence of LPA risk variants in adult individuals with FH enrolled in the Italian LIPIGEN (Lipid Transport Disorders Italian Genetic Network) study, with (FH/M+) or without (FH/M-) a causative genetic variant. Methods and Results An lp(a) [lipoprotein(a)] genetic score was calculated by summing the number risk-increasing alleles inherited at rs3798220 and rs10455872 variants. Overall, in the 4.6% of 1695 patients with clinically diagnosed FH, the phenotype was not explained by a monogenic or polygenic cause but by genotype associated with high lp(a) levels. Among 765 subjects with FH/M- and 930 subjects with FH/M+, 133 (17.4%) and 95 (10.2%) were characterized by 1 copy of either rs10455872 or rs3798220 or 2 copies of either rs10455872 or rs3798220 (lp(a) score ≥1). Subjects with FH/M- also had lower mean levels of pretreatment low-density lipoprotein cholesterol than individuals with FH/M+ (t test for difference in means between FH/M- and FH/M+ groups <0.0001); however, subjects with FH/M- and lp(a) score ≥1 had higher mean (SD) pretreatment low-density lipoprotein cholesterol levels (223.47 [50.40] mg/dL) compared with subjects with FH/M- and lp(a) score=0 (219.38 [54.54] mg/dL for), although not statistically significant. The adjustment of low-density lipoprotein cholesterol levels based on lp(a) concentration reduced from 68% to 42% the proportion of subjects with low-density lipoprotein cholesterol level ≥190 mg/dL (or from 68% to 50%, considering a more conservative formula). Conclusions Our study supports the importance of measuring lp(a) to perform the diagnosis of FH appropriately and to exclude that the observed phenotype is driven by elevated levels of lp(a) before performing the genetic test for FH

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

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