Associates and Determinants of the MGNREGA: An Indian Case Study of Rural Transformation

Purpose: The study sought to investigate the various types of employees who took part in the MGNREGA programme. According to the findings, the employment scenario is determined by economic status, social group, education, gender, family size, and land holdings. Approach/Methodology/Design: A micro-level analysis was conducted along the dichotomies of various variables to consider the associates and determinates of labour participation in MGNREGA. The Chi-square test and logistic regression were used to analyze data from the survey's various indicators. Findings: The employment scenario is determined by economic status, social group, education, gender, family size, and land holdings. MGNREGA is more appealing to households that belong to a disadvantaged community, have a low level of education, or have a large family. Increased working days with efficient work in rural areas are needed to serve all areas. Originality/value: The traditional model of joint households in rural areas is being broken as a result of the program's implementation, as a proportion of work cards are held by smaller families. The educational level of the beneficiaries has been discovered to be lower. According to the results, the socio-economic condition of households regularly working under the MGNREGA scheme is extremely poor in rural areas

Geospatial mapping and drinking water quality status of fluoride endemic hilly District Doda (J&K), India

In the present study, an attempt has been made to investigate the drinking water quality status of various surface and ground water sources and the supplied water from two water filtration plants supplying drinking water to Doda town and its adjoining areas by using Arithmetic Water Quality Index (WQI) and geospatial mapping techniques. Doda is fluoride endemic district of Jammu and Kashmir State where groundwater fluoride concentration upto 7.0 mg/L is recorded. Water samples collected from about twenty two drinking water sources from two blocks of Doda district (Bhagwah and Doda blocks) were analyzed at pre-determined locations marked using handheld GPS(Montana 650). These locations formed the attribute database for the study based on which fluoride distribution maps have been derived and integrated with Arithmetic WQI through Inverse distance weighted (IDW) interpolation technique. Prepared thematic maps have confirmed the vulnerability of the drinking water sources and water supply systems in the study area, thus, posing a serious public health concern. Based on the WQI, water quality status of Beoli filtration plant (WQI=43.26) falls under the category of good water whereas that of Moochan filtration plant (WQI=157.41) has been classified as unfit for drinking. The geochemical evolution of the water studied using Piper’s diagram has shown mixed type of hydrochemical facies. Coefficient of correlation(r) between different parameters has indicated significant correlation between several parameters.  The study urges the concerned government authorities to make provisions for providing safe drinking water to public which is free of turbidity and low in fluoride concentration

Inflammasomes: Emerging Central Players in Cancer Immunology and Immunotherapy

Inflammation has an established role in cancer development and progression and is a key player in regulating the entry and exit of immune cells in the tumor microenvironment, mounting a significant impact on anti-tumor immunity. Recent studies have shed light on the role of inflammasomes in the regulation of inflammation with a focus on the subsequent effects on the immunobiology of tumors. To generate strong anti-tumor immunity, cross-talk between innate, and adaptive immune cells is necessary. Interestingly, inflammasome bridges both arms of the immune system representing a unique opportunity to manipulate the role of inflammation in favor of tumor suppression. In this review, we discuss the impact of inflammasomes on the regulation of the levels of inflammatory cytokines-chemokines and the efficacy of immunotherapy response in cancer treatment

Expression of tumor-associated glycoprotein-72 (TAG-72) antigen in human prostatic adenocarcinomas.

Tumor-specific antigens are usually defined by monoclonal antibodies (MAbs) and can play critical roles in the diagnosis and therapy of carcinomas. Despite advances in the understanding of the molecular genetics of human prostate carcinomas, therapeutic approaches require that tumor-specific markers, preferably on the cell surface, should be defined. In this study, we examined the expression of an oncofetal antigen tumor-associated glycoprotein-72 (TAG-72) in prostatic adenocarcinomas with a Gleason grade of six or higher. Using a second generation MAb CC49 against TAG-72, immunoreactivity was detected in 88% (29/33) of the prostatic cancer tissues. Occasionally, the benign epithelium showed a very faint immunostaining but in most of the specimens, no reactivity was detected. Positive staining was present in the cytoplasm and the cell membrane of the malignant cells similar to reports on other cancer tissues. A weaker staining pattern of this antigen was seen in poorly differentiated areas. A significant negative correlation (r = -0.36, p \u3c 0.05) was observed between TAG-72 antigen expression and Gleason grade. The TAG-72 antigen expression in prostatic adenocarcinomas may be used as a target for radioimmunotherapy by the multivalent single chain antibody CC49 constructs recently generated by our group

Circulatory MIC-1 as a Determinant of Prostate Cancer Racial Disparity

In this study, we investigated the potential of MIC-1 (macrophage inhibitory cytokine-1) on the severity of prostate cancer between African American men and Caucasians. Differences between the races were examined using Mann–Whitney tests for continuous variables and Fisher’s exact tests for categorical variables. Pearson’s correlation coefficient was used to identify associations between continuous measures across all samples and within each race. Analysis of variance, including clinical parameters, was used to identify differences in serum and urine MIC-1 levels between races. We found significant differences between the two races for age (p = 0.01), Gleason scores (p = 0.01), and stage of disease (p = 0.03). African American men in the study had higher Gleason scores (mean = 6.9) than Caucasians (mean = 6.5), during earlier stages of the disease. In Caucasian men with prostate cancer, serum MIC-1 expression was positively associated with age (r = 0.7, p < 0.01). However, African American men had highly expressed MIC-1 and high Gleason scores (r = 0.16, p = 0.3). Interestingly, the urine MIC-1 level was significantly higher in African American men with prostate cancer than in Caucasian patients. It appeared to be more sensitive and specific for African Americans (AUC = 0.85 vs. 0.56). Thus, high circulatory MIC-1 in prostate cancer patients may indicate MIC-1 as a potential biomarker to improve the diagnostic ability of an aggressive stage of prostate cancer in African American men. However, a larger cohort of sample analysis is required to validate these observations

Retracted: Technique of Intravesical Laparoscopy for Ureteric Reimplantation to Treat VUR

Inflammation-associated studies entice specific attention due to inflammation’s role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized. A focused class of inflammatory regulators known as inflammasomes has recently gained attention in cancer development. Inflammasomes are a multiprotein complex that drives a cascade of proinflammatory cytokines regulating various cellular activities. Inflammasomes activation is linked with infection, stress, or danger signals, which are common events within the prostate gland. In this study, we review the potential of inflammasomes in understanding the role of inflammation in prostate cancer

Review Article From Inflammation to Prostate Cancer: The Role of Inflammasomes

Inflammation-associated studies entice specific attention due to inflammation's role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized. A focused class of inflammatory regulators known as inflammasomes has recently gained attention in cancer development. Inflammasomes are a multiprotein complex that drives a cascade of proinflammatory cytokines regulating various cellular activities. Inflammasomes activation is linked with infection, stress, or danger signals, which are common events within the prostate gland. In this study, we review the potential of inflammasomes in understanding the role of inflammation in prostate cancer