1,756 research outputs found
Coefficient invariances of Convex functions
For convex univalent functions we give instances where the sharp bound for
various coefficient functionals are identical to those for the corresponding
bound for the inverse function. We give instances where the sharp bounds differ
and also suggest some significant open problems.Comment: 9 page
Research to stop tobacco deaths
In 2003, governments adopted the Framework Convention on Tobacco Control, the worldâs first global health treaty. In the decade since the treaty was adopted by 178 member states of the World Health Organization, there have been substantial achievements in reducing tobacco use around the world. Research and evidence on the impact of interventions and policies have helped drive this policy progress. An increased and sustained focus on research is needed in the future to ensure that the gains of the global tobacco control movement are maintained, particularly in low- and middle-income countries, which are affected most strongly by the tobacco epidemic. In addition to current priorities, greater attention is needed to research related to trade agreements, prevention among girls, and the appropriate response to nicotine-based noncombustibles (including e-cigarettes)
Blip glitches in Advanced LIGO data
Blip glitches are short noise transients present in data from ground-based
gravitational-wave observatories. These glitches resemble the
gravitational-wave signature of massive binary black hole mergers. Hence, the
sensitivity of transient gravitational-wave searches to such high-mass systems
and other potential short duration sources is degraded by the presence of blip
glitches. The origin and rate of occurrence of this type of glitch have been
largely unknown. In this paper we explore the population of blip glitches in
Advanced LIGO during its first and second observing runs. On average, we find
that Advanced LIGO data contains approximately two blip glitches per hour of
data. We identify four subsets of blip glitches correlated with detector
auxiliary or environmental sensor channels, however the physical causes of the
majority of blips remain unclear
The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin
Schizophrenia is often a severe and debilitating mental illness, frequently associated with impairments in social cognition that hinder individuals' abilities to relate to others and integrate effectively in society. Oxytocin has emerged as a putative therapeutic agent for treating social deficits in schizophrenia, but the mode of action remains unclear. This placebo-controlled crossover study aimed to elucidate the neural underpinnings of oxytocin administration in patients with schizophrenia. 20 patients with schizophrenia were examined using functional magnetic resonance imaging under oxytocin (40 IU) or placebo nasal spray. Participants performed a stochastically rewarded decision-making task that incorporated elements of social valence provided by different facial expressions, i.e. happy, angry and neutral. Oxytocin attenuated the normal bias in selecting the happy face accompanied by reduced activation in a network of brain regions that support mentalising, processing of facial emotion, salience, aversion, uncertainty and ambiguity in social stimuli, including amygdala, temporo-parietal junction, posterior cingulate cortex, precuneus and insula. These pro-social effects may contribute to the facilitation of social engagement and social interactions in patients with schizophrenia and warrant further investigation in future clinical trials for social cognitive impairments in schizophrenia
An interdisciplinary framework for measuring and supporting adherence in HIV prevention trials of ARVâbased vaginal rings
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138229/1/jia29158.pd
Duration of wrinkle correction following repeat treatment with Juvéderm hyaluronic acid fillers
Many patients elect to have repeat treatments with hyaluronic acid dermal fillers to maintain wrinkle correction, but the clinical performance of these products after repeat treatments has not been formally assessed. The primary objective of this study was to evaluate the effectiveness of JuvĂ©derm injectable gel (JuvĂ©derm Ultra, JuvĂ©derm Ultra Plus, and JuvĂ©derm 30) through 1 year after repeat treatment of nasolabial folds (NLFs) that were previously treated with JuvĂ©derm or Zyplast 6â9 months prior to the repeat treatment. Upon completion of the pivotal IDE clinical trial for JuvĂ©derm, five of the original 11 study sites were selected to participate in an extended follow-up evaluation, and a total of 80 subjects were enrolled. For the JuvĂ©derm-treated NLFs in each treatment group, the median injection volume was 1.5â1.6 mL for initial treatment but only 0.5â0.6 mL for the repeat treatment (p < 0.0001). Mean Investigator-assigned NLF severity scores on a scale of 0â4 for the JuvĂ©derm-treated NLFs improved from 2.5â2.7 (moderate to severe) at baseline to 1.2â1.5 (mild) just prior to repeat treatment (>24 weeks) and 0.7â0.9 (mild) at 4 weeks after repeat treatment. At 48 weeks post-repeat treatment, the mean NLF scores were 1.1â1.3 (mild), and 78â90% of subjects were considered responders (â„1 point improvement). Thus, subjects sustained a total of 18â21 months of wrinkle correction with a repeat treatment at 6â9 months and needed substantially less filler (60% less) for repeat treatment than for initial treatment, indicating that retreatment at this timepoint may be beneficial to patients
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