Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system.

The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E. Corpet and S. Tache, Nutr. Cancer, 43: 1-21, 2002). Here we add the results of a systematic review of the effect of dietary and chemopreventive agents on the tumor yield in Min mice. The review is based on the results of 179 studies from 71 articles and is displayed also on the internet http://corpet.net/min.(2) We compared the efficacy of agents in the Min mouse model and the AOM rat model, and found that they were correlated (r = 0.66; P < 0.001), although some agents that afford strong protection in the AOM rat and the Min mouse small bowel increase the tumor yield in the large bowel of mutant mice. The agents included piroxicam, sulindac, celecoxib, difluoromethylornithine, and polyethylene glycol. The reason for this discrepancy is not known. We also compare the results of rodent studies with those of clinical intervention studies of polyp recurrence. We found that the effect of most of the agents tested was consistent across the animal and clinical models. Our point is thus: rodent models can provide guidance in the selection of prevention approaches to human colon cancer, in particular they suggest that polyethylene glycol, hesperidin, protease inhibitor, sphingomyelin, physical exercise, epidermal growth factor receptor kinase inhibitor, (+)-catechin, resveratrol, fish oil, curcumin, caffeate, and thiosulfonate are likely important preventive agents

How shall we use the proteomics toolbox for biomarker discovery?

Biomarker discovery for clinical purposes is one of the major areas in which proteomics is used. However, despite considerable effort, the successes have been relatively scarce. In this perspective paper, we try to highlight and analyze the main causes for this limited success, and to suggest alternate strategies, which will avoid them, without eluding the foreseeable weak points of these strategies. Two major strategies are analyzed, namely, the switch from body fluids to cell and tissues for the initial biomarker discovery step or, if body fluids must be analyzed, the implementation of highly selective protein selection strategies

Semiclassical magnetotransport in graphene n-p junctions

We provide a semiclassical description of the electronic transport through graphene n-p junctions in the quantum Hall regime. This framework is known to experimentally exhibit conductance plateaus whose origin is still not fully understood. In the magnetic regime (E < vF B), we show the conductance of excited states is essentially zero, while that of the ground state depends on the boundary conditions considered at the edge of the sample. In the electric regime (E > vF B), for a step-like electrostatic potential (abrupt on the scale of the magnetic length), we derive a semiclassical approximation for the conductance in terms of the various snake-like trajectories at the interface of the junction. For a symmetric configuration, the general result can be recovered using a simple scattering approach, providing a transparent analysis of the problem under study. We thoroughly discuss the semiclassical predicted behavior for the conductance and conclude that any approach using fully phase-coherent electrons will hardly account for the experimentally observed plateaus.Comment: 22 pages, 19 figure

Fingerprints of Majorana fermions in current-correlations measurements from a superconducting tunnel microscope

We compute various current correlation functions of electrons flowing from a topological nanowire to the tip of a superconducting scanning tunnel microscope and identify fingerprints of a Majorana bound state. In particular, the spin resolved cross-correlations are shown to display a clear distinction between the presence of a such an exotic state (negative correlations) and an Andreev bound state (positive correlations). Similarity and differences with measurements with a normal tunnel microscope are also discussed, like the robustness to finite temperature for instance.Comment: 7 pages, 2 figure

Graphene n-p junction in a strong magnetic field: a semiclassical study

We provide a semiclassical description of the electronic transport through graphene n-p junctions in the quantum Hall regime. A semiclassical approximation for the conductance is derived in terms of the various snake-like trajectories at the interface of the junction. For a symmetric (ambipolar) configuration, the general result can be recovered by means of a simple scattering approach, providing a very transparent qualitative description of the problem under study. Consequences of our findings for the understanding of recent experiments are discussed.Comment: 10 pages, 2 figure