Performance Evaluation of end-to-end security protocols in an Internet of Things

Wireless Sensor Networks are destined to play a fundamental role in the next-generation Internet, which will be characterized by the Machine-to-Machine paradigm, according to which, embedded devices will actively exchange information, thus enabling the development of innovative applications. It will contribute to assert the concept of Internet of Things, where end-to-end security represents a key issue. In such context, it is very important to understand which protocols are able to provide the right level of security without burdening the limited resources of constrained networks. This paper presents a performance comparison between two of the most widely used security protocols: IPSec and DTLS. We provide the analysis of their impact on the resources of embedded devices. For this purpose, we have modified existing implementations of both protocols to make them properly run on our hardware platforms, and we have performed an extensive experimental evaluation study. The achieved results are not a consequence of a classical simulation campaign, but they have been obtained in a real scenario that uses software and hardware typical of the current technological developments. Therefore, they can help network designers to identify the most appropriate secure mechanism for end-to-end IP communications involving constrained devices

Drosophila Histone Deacetylase-3 Controls Imaginal Disc Size through Suppression of Apoptosis

Histone deacetylases (HDACs) execute biological regulation through post-translational modification of chromatin and other cellular substrates. In humans, there are eleven HDACs, organized into three distinct subfamilies. This large number of HDACs raises questions about functional overlap and division of labor among paralogs. In vivo roles are simpler to address in Drosophila, where there are only five HDAC family members and only two are implicated in transcriptional control. Of these two, HDAC1 has been characterized genetically, but its most closely related paralog, HDAC3, has not. Here we describe the isolation and phenotypic characterization of hdac3 mutations. We find that both hdac3 and hdac1 mutations are dominant suppressors of position effect variegation, suggesting functional overlap in heterochromatin regulation. However, all five hdac3 loss-of-function alleles are recessive lethal during larval/pupal stages, indicating that HDAC3 is essential on its own for Drosophila development. The mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid. In contrast, although HDAC1 mutants also display small imaginal discs, this appears to result from reduced proliferation rather than from elevated apoptosis. The connection between HDAC loss and apoptosis is important since HDAC inhibitors show anticancer activities in animal models through mechanisms involving apoptotic induction. However, the specific HDACs implicated in tumor cell killing have not been identified. Our results indicate that protein deacetylation by HDAC3 plays a key role in suppression of apoptosis in Drosophila imaginal tissue

Industrialitation Trends in Southern and Eastern Mediterranean

Il saggio analizza i recenti cambiamenti politici e dinamiche socio economiche dei Paesi Mediterrane

Partecipazione e identità territoriale. Il caso di Castel del Giudice (Molise)

n recent years, there is growing attention to neo-endogenous development approaches. In these practices, the focus is on people’s needs, abilities and expectations, this also implies the inclusion of an ethical dimension of the development process, to be achieved through a significant participation of the community and respect for the values expressed. A process that, according to the latest scientific debate, would be organized around the so-called “social innovation”. In this contribution, social innovation is explored in relation to the idea of development that seems to be to underline and from it, specific interpretations of the concept of territorial identity would emerge. The conceptual framework outlined leads the observation of the case study, a small village in Molise, with the aim of verifying the applicability of a scheme of identification about social innovation and of interpreting its relationship with territorial identity. The risk of “disappearing” has prompted significant changes driven by the vision and commitment of a group of actors and the local community itself

Stereochemistry of the biotransformation of 1-hexene and 2-methyl-1-hexene with rat liver microsomes and purified P450s of rats and humans

The epoxidation of 1-hexene (1a) and 2-methyl-1-hexene (1b), two hydrocarbons present in the ambient air as: pollutants, is catalyzed by some human and rat P450 enzymes. The enantioselectivities of these processes, when the reactions were carried out using rat and human liver microsomal preparations, were modest and dependent on both P450 composition and substrate concentrations. Various P450 isoforms (rat P450 2B1 and human P450 2C10 and 2A6) catalyzed the double bond oxidation of 1a and 1b with different product enantioselectivities. In the case of 1a, a moderately enantioselective hydroxylation at the allylic C(3) with the formation of 1-hexen-3-ol (4a) by microsomes from control or preinduced rats was also observed. The oxidation of this metabolite was, in turn, catalyzed by rat liver microsomes and mainly by rat P450 2C11, leading exclusively to the formation of 1-hexen-3-one, with no double bond epoxidation being observed. The stereochemical course of the microsomal epoxide hydrolase-catalyzed hydrolysis of the epoxy alcohols, threo-(+/-)- and erythro-(+/-)-1,2-epoxyhexan-3-ol, theoretically expected to be formed from 4a, has been investigated