The very faint hard state of the persistent neutron star X-ray binary SLX 1737-282 near the Galactic centre

We report on a detailed study of the spectral and temporal properties of the neutron star low mass X-ray binary SLX 1737-282, which is located only ~1degr away from Sgr A. The system is expected to have a short orbital period, even within the ultra-compact regime, given its persistent nature at low X-ray luminosities and the long duration thermonuclear burst that it has displayed. We have analysed a Suzaku (18 ks) observation and an XMM-Newton (39 ks) observation taken 7 years apart. We infer (0.5-10 keV) X-ray luminosities in the range 3-6 x10^35erg s-1, in agreement with previous findings. The spectra are well described by a relatively cool (kTbb = 0.5 keV) black body component plus a Comptonized emission component with {\Gamma} ~1.5-1.7. These values are consistent with the source being in a faint hard state, as confirmed by the ~ 20 per cent fractional root mean square amplitude of the fast variability (0.1 - 7 Hz) inferred from the XMM-Newton data. The electron temperature of the corona is >7 keV for the Suzaku observation, but it is measured to be as low as ~2 keV in the XMM-Newton data at higher flux. The latter is significantly lower than expected for systems in the hard state. We searched for X-ray pulsations and imposed an upper limit to their semi-amplitude of 2 per cent (0.001 - 7 Hz). Finally, we investigated the origin of the low frequency variability emission present in the XMM-Newton data and ruled out an absorption dip origin. This constraint the orbital inclination of the system to 65 degr unless the orbital period is longer than 11 hr (i.e. the length of the XMM-Newton observation).Comment: 7 pages, 4 figures, 1 table. Accepted for publication in MNRA

Probing variability patterns of the Fe K line complex in bright nearby AGNs

The unprecedented sensitivity of current X-ray telescopes allows for the first time to address the issue of the Fe K line complex variability patterns in bright, nearby AGNs. We examine XMM-Newton observations of the brightest sources of the FERO sample of radio-quiet type 1 AGNs with the aim of characterizing the temporal behaviour of Fe K complex features. A systematic mapping of residual flux above and below the continuum in the 4-9 keV range is performed in the time vs energy domain, with the purpose of identifying interesting spectral features in the three energy bands: 5.4-6.1 keV, 6.1-6.8 keV and 6.8-7.2 keV, corresponding respectively to the redshifted, rest frame and blueshifted or highly ionized Fe Kalpha line bands. The variability significance is assessed by extracting light curves and comparing them with MonteCarlo simulations. The time-averaged profile of the Fe K complex revealed spectral complexity in several observations. Red- and blue-shifted components (either in emission or absorption) were observed in 30 out of 72 observations, with an average ~90 eV for emission and ~ -30 eV for absorption features. We detected significant line variability (with confidence levels ranging between 90% and 99.7%) within at least one of the above energy bands in 26 out of 72 observations on time scales of ~6-30 ks. Reliability of these features has been carefully calculated using this sample and has been assessed at ~3sigma confidence level. This work increases the currently scanty number of detections of variable, energy shifted, Fe lines and confirms the reliability of the claimed detections. We found that the distribution of detected features is peaked at high variability significances in the red- and blue-shifted energy bands, suggesting an origin in a relativistically modified accretion flow.Comment: Accepted for publication in Astronomy & Astrophysic

Injection Pattern Investigation for Gasoline Partially Premixed Combustion Analysis

Nowadays, compression-ignited engines are considered the most efficient and reliable technology for automotive applications. However, mainly due to the current emission regulations, that require increasingly stringent reductions of NOx and particulate matter, the use of diesel-like fuels is becoming a critical issue. For this reason, a large amount of research and experimentation is being carried out to investigate innovative combustion techniques suitable to simultaneously mitigate the production of NOx and soot, while improving engine efficiency. In this scenario, the combined use of compression-ignited engines and gasoline-like fuels proved to be very promising, especially in case the fuel is directly-injected in the combustion chamber at high pressure. The presented study analyzes the combustion process produced by the direct injection of small amounts of gasoline in a compression-ignited light-duty engine. The engine under investigation has been modified to guarantee a stable engine operation over its whole operating range, that is achieved controlling boost pressure and temperature, together with the design of the injection pattern. Experimental tests have been performed to highlight the impact of several control variables on the combustion effectiveness, i.e. on combustion efficiency and ignition delay. To identify the main mechanisms which impact the start of the combustion process and the sensitivity to the variation of the main control parameters, several tests have been run, directly-injecting constant amounts of gasoline in a compression ignited engine. These tests have been performed changing intake pressure and temperature (when suitable to maintain combustion stability), fuel pressure and injection timing within the cycle

The value of case reports and spontaneous reporting systems for pharmacovigilance and clinical practice

Non present

Investigation of Gasoline Partially Premixed Combustion with External Exhaust Gas Recirculation

The stringent emission regulations for Internal Combustion Engines (ICEs) spawned a great amount of research in the field of innovative combustion approaches characterized by high efficiency and low emissions. Previous research demonstrate that such promising techniques, named Low-Temperature Combustion (LTC), combine the benefits of Compression Ignition (CI) engines, such as high compression ratio and unthrottled lean mixture, with low engine-out emissions using a properly premixed air-fuel mixture. Due to longer ignition delay and high volatility compared to diesel, gasoline-like fuels show good potential for the generation of a highly premixed charge, which is needed to reach LTC characteristics. In this scenario, gasoline Partially Premixed Combustion (PPC), characterized by the high-pressure direct injection of gasoline, showed good potential for the simultaneous reduction of pollutants and emissions in CI engines. However, previous research on gasoline CI highlight that a key factor for the optimization of both efficiency and pollutants is the proper management of Exhaust Gas Recirculation (EGR). This work presents the experimental investigation performed running a light-duty CI engine, operated with gasoline PPC, and varying the mass of recirculated gases trapped in the combustion chamber. To guarantee the stability of gasoline autoignition in all the tested conditions, a specific experimental layout has been developed to accurately quantify the amount of trapped residual gases due to the internal and external EGR. The obtained results clearly highlight the impact of EGR on the combustion process and emissions, demonstrating that optimization of charge dilution with EGR is fundamental to guarantee the optimal compromise between efficiency and emissions over the whole operating range

Ultrasound imaging, a stethoscope for body composition assessment

Bone and muscle are two deeply interconnected organs and a strong relationship between them exists in their development and maintenance. The peak of both bone and muscle mass is achieved in early adulthood, followed by a progressive decline after the age of 40. The increase in life expectancy in developed countries resulted in an increase of degenerative diseases affecting the musculoskeletal system. Osteoporosis and sarcopenia represent a major cause of morbidity and mortality in the elderly population and are associated with a significant increase in healthcare costs. Several imaging techniques are currently available for the non-invasive investigation of bone and muscle mass and quality. Conventional radiology, dual energy X-ray absorptiometry (DXA), computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound often play a complementary role in the study of osteoporosis and sarcopenia, depicting different aspects of the same pathology. This paper presents the different imaging modalities currently used for the investigation of bone and muscle mass and quality in osteoporosis and sarcopenia with special emphasis on the clinical applications and limitations of each technique and with the intent to provide interesting insights into recent advances in the field of conventional imaging, novel high-resolution techniques and fracture risk

Graded elastic metasurface for enhanced energy harvesting

In elastic wave systems, combining the powerful concepts of resonance and spatial grading within structured surface arrays enable resonant metasurfaces to exhibit broadband wave trapping, mode conversion from surface (Rayleigh) waves to bulk (shear) waves, and spatial frequency selection. Devices built around these concepts allow for precise control of surface waves, often with structures that are subwavelength, and utilise Rainbow trapping that separates the signal spatially by frequency. Rainbow trapping yields large amplifications of displacement at the resonator positions where each frequency component accumulates. We investigate whether this amplification, and the associated control, can be used to create energy harvesting devices; the potential advantages and disadvantages of using graded resonant devices as energy harvesters is considered. We concentrate upon elastic plate models for which the A0 mode dominates, and take advantage of the large displacement amplitudes in graded resonant arrays of rods, to design innovative metasurfaces that trap waves for enhanced piezoelectric energy harvesting. Numerical simulation allows us to identify the advantages of such graded metasurface devices and quantify its efficiency, we also develop accurate models of the phenomena and extend our analysis to that of an elastic half-space and Rayleigh surface waves

Impulse Control Disorders by Dopamine Partial Agonists: A Pharmacovigilance-Pharmacodynamic Assessment Through the FDA Adverse Event Reporting System

BACKGROUND: The dopaminergic partial agonism of the so-called third-generation antipsychotics (TGAs; aripiprazole, brexpiprazole, cariprazine) is hypothesized to cause impulse control disorders (ICDs). Relevant warnings by the Food and Drug Administration (FDA) were posted on aripiprazole (2016) and brexpiprazole (2018). Our study investigated the FDA Adverse Event Reporting System and the pharmacodynamic CHEMBL database to further characterize TGA-induced ICDs. METHODS: We downloaded and pre-processed the FDA Adverse Event Reporting System up to December 2020. We adapted Bradford Hill criteria to assess each TGA's -and secondarily other antipsychotics'-causal role in inducing ICDs (pathological gambling, compulsive shopping, hyperphagia, hypersexuality), accounting for literature and disproportionality. ICD clinical features were analyzed, and their pathogenesis was investigated using receptor affinities. RESULTS: A total of 2708 reports of TGA-related ICDs were found, primarily recording aripiprazole (2545 reports, 94%) among the drugs, and gambling (2018 reports, 75%) among the events. Bradford-Hill criteria displayed evidence for a causal role of each TGA consistent across subpopulations and when correcting for biases. Significant disproportionalities also emerged for lurasidone with compulsive shopping, hyperphagia, and hypersexuality, and olanzapine and ziprasidone with hyperphagia. Time to onset varied between days and years, and positive dechallenge was observed in 20% of cases. Frequently, co-reported events were economic (50%), obsessive-compulsive (44%), and emotional conditions (34%). 5-Hydroxytryptamine receptor type 1a agonism emerged as an additional plausible pathogenetic mechanism. CONCLUSIONS: We detected an association between TGAs and ICDs and identified a new signal for lurasidone. ICD characteristics are behavior specific and may heavily impact on life. The role of 5-Hydroxytryptamine receptor type 1a agonism should be further explored

Total orthotopic small bowel transplantation in swine under FK 506

Previous experimental studies in rodents and in dogs have established the efficacy of FK 506 in controlling the immunologic events following small bowel or multivisceral transplantation.1–5 To complete the assessment of FK 506 in experimental small bowel transplantation, we present here our experience with the frequently used swine model