Desarrollo de una taxonomía de las intervenciones farmacéuticas en pacientes VIH+ basados en el modelo CMO

Objective: To agree on a proposal for pharmaceutical interventions and establish their classification taxonomy according to the CMO-Pharmaceutical Care Model (Capacity-Motivation- Opportunity). Method: A study conducted between March and May, 2016. Two phases of development were defined. A literature review was initially conducted. Then, the DELPHI-Rand-UCLA methodology was used in order to reach a consensus about those interventions selected, and to define the taxonomy. Fifteen (15) experts, specialists in Pharmaceutical Care for HIV+ patients, were selected. This selection was explicitly conducted, following a protocol in order to avoid any bias. An initial proposal was developed according to the interventions extracted from Phase 1. These were tentatively classified according to the CMO Model, in a category based on their design and utility. Three issues were raised from the initial question: Do you agree with the proposed classification? If not, there was an option to re-categorize. Additionally, they were asked about the importance, priority and impact to achieve pharmacotherapeutic objectives that they would assign to it. Interventions were classified according to the degree of agreement. Once a consensus was reached, the final taxonomy was established. Results: Eighteen (18) articles were finally considered. The initial proposal included 20 pharmaceutical interventions with the following classification: seven in Capacity, eight in Motivation, and five in Opportunity. Those interventions considered to have greater importance and priority were: Review and Validation, Safety, and Adherence. The interventions with the greatest impact were: Review and Validation, Coordination, Adherence, and Motivation. On the other hand, the lowest scores for importance were for: Planning and Social Coordination; and in terms of impact: Social Coordination. Conclusions: The taxonomy reached by consensus will allow to classify pharmaceutical interventions with the new model, and therefore to conduct an improved research and patient care

Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region

The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases. The release of EVs by Trypanosoma cruzi, the causative agent of Chagas disease, has recently been described, with different protein cargoes including the MASP multigene family of proteins MASPs are specific to this parasite and characterized by a conserved C-terminal (C-term) region and an N-terminal codifying for a signal peptide (SP). In this investigation, we identified immature MASP proteins containing the MASP SP in EVs secreted by the infective forms of the parasite. Those EVs are responsible for the formation of immune complexes (ICs) containing anti-MASP SP IgGs in patients with different (cardiac, digestive and asymptomatic) chronic Chagas disease manifestations. Moreover, purified EVs as well as the MASP SP inhibit the action of the complement system and also show a significant association with the humoral response in patients with digestive pathologies. These findings reveal a new route for the secretion of MASP proteins in T. cruzi, which uses EVs as vehicles for immature and misfolded proteins, forming circulating immune complexes. Such complexes could be used in the prognosis of digestive pathologies of clinical forms of Chagas disease.Fil: Díaz Lozano, Isabel María. Universidad de Granada; EspañaFil: De Pablos, Luis Miguel. Universidad de Granada; España. University Of York;Fil: Longhi, Silvia Andrea. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires; ArgentinaFil: Osuna, Antonio. Universidad de Granada; Españ

Notas florísticas del Valle del Jerte (Cáceres) ,II.

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Nuevas adiciones a la bibliografía de Carlos Pau.

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Cerinthe gymnandra Gasparr. (Doraginaceae) on Ihe Iberian Peninsula

CARRAscO, Nl. A. >994. Cecínthe gy¡nttand'-a Gasparr. on the Ibetian Península. Bot. Co,nplutensis, ls.- 75-82. Estudiamos Cerinthe gynmandra Gasparr. en la Península Ibérica, presentando en una tabla comparativa las características de las cuatro variedades de la especie. Comentamos además dos táxones descritos sobre materiales españoles: C. gymnandra Gasparr. var. ibetica Caballero y C. major L. var. valentina Pau, incluidos actualmente en C. gvrnnandra Gasparr. var. gymnandra.CARRAscO, Nl. A. >994. Cecínthe gy¡nttand'-a Gasparr. on the Ibetian Península. Bot. Co,nplutensis, ls.- 75-82. Estudiamos Cerinthe gynmandra Gasparr. en la Península Ibérica, presentando en una tabla comparativa las características de las cuatro variedades de la especie. Comentamos además dos táxones descritos sobre materiales españoles: C. gymnandra Gasparr. var. ibetica Caballero y C. major L. var. valentina Pau, incluidos actualmente en C. gvrnnandra Gasparr. var. gymnandra

Notas fiorísticas del valle del Jerte (Cáceres)

Sin resume

Aportaciones al conocimiento de la flora de Ciudad Real (España), II.

MONGE, C., & CARRASCO, M. A. Aportaciones al conocimiento de la flora de Ciudad Real (España), II. Roe. Complutensis 16: 109-1 13. Presentamos en este trabajo lO táxones recolectados en las Sierras dcl Peral, del Cristo y Alhambra en la provincia de Ciudad Real (España). De ellas, nueve son primeras citas provinciales y cuatro de ellas se citan además por primera vez para La Mancha. Comentamos características taxonómicas de dos especies.MONGE, C., & CARRASCO, M. A. Aportaciones al conocimiento de la flora de Ciudad Real (España), II. Roe. Complutensis 16: 109-1 13. Presentamos en este trabajo lO táxones recolectados en las Sierras dcl Peral, del Cristo y Alhambra en la provincia de Ciudad Real (España). De ellas, nueve son primeras citas provinciales y cuatro de ellas se citan además por primera vez para La Mancha. Comentamos características taxonómicas de dos especies

Dynamic parameter estimation problem for ethanol production from seaweed

Ethanol has been studied extensively as one of the current and probably future energy vectors. Fermentation of hydrolysed oligosaccharides from macroalgae biomass to ethanol has been certified, and several processing options have been proposed. In the present work, we model the production of ethanol based on Laminaria, a seaweed genus that belongs to the so-called "brown algae" group, as the carbon source. In brown algae, the most relevant sugars that can be used as substrate for fermentation are mannitol -the alcohol form of the sugar mannose- and laminaran, a linear polysaccharide of(1,3)-β-Dglucopyranose. We consider the yeast Pichia angophorae as the fermenting microorganism. The model includes dynamic mass balances for biomass, ethanol, mannitol and laminaran. Growth is controlled via limiting functions that modify the biomass equation for temperature and oxygen transfer rate (OTR). It is also modified by including a term that considers inhibition by ethanol. Based on the proposed model, a dynamic parameter estimation problem is formulated, the objective function being weighted least-squares fit to data, subject to the mass balance equations. The data set for parameter estimation was obtained in batch liquid cultures, with experiments performed over 40 hours. Numerical results provide useful insights on ethanol production using macroalgae biomass as carbon sourceFil: Delpino, Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: de Genaro, Pablo Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Di Maggio, Jimena Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Estrada, Vanina Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Díaz, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentin