How preserved is emotion recognition in Alzheimer disease compared with behavioral variant frontotemporal dementia?

Background: Emotion deficits are a recognised biomarker for behavioural variant frontotemporal dementia (bvFTD), but recent studies have reported emotion deficits also in Alzheimer’s disease (AD). Methods: A hundred and twenty-three participants (33 AD, 60 bvFTD, 30 controls) were administered a facial emotion recognition test, to investigate the clinical factors influencing the diagnostic distinction on this measure. Binomial regression analysis revealed that facial emotion recognition in AD was influenced by disease duration and MMSE, whereas the same was not true for bvFTD. Based on this information, we median-split the AD group on disease duration (3 years) or MMSE (24) and compared the facial emotion recognition performance of mild-AD, moderate-AD, bvFTD patients and controls. Results: Results showed that very mild-AD performed consistently at control levels for all emotions. By contrast, mild/moderate-AD and bvFTD were impaired compared to controls on most emotions. Interestingly, mild/moderate-AD were significantly impaired compared to very mild-AD on total score, anger and sadness subscores. Logistic regression analyses corroborated these findings with ~94% of very mild-AD being successfully distinguished from bvFTD at presentation, while this distinction was reduced to ~78% for mild/moderate-AD. Conclusions: Facial emotion recognition in AD is influenced by disease progression, with very mild-AD being virtually intact for emotion performance. Mild/moderate-AD and bvFTD show consistent impairment in emotion recognition, with bvFTD being worse. A disease progression of over 3 years or a MMSE lower than 24 should warrant caution to put too much emphasis on emotion recognition performance in the diagnostic distinction of AD and bvFTD

Constraining the evolution of the CMB temperature with SZ measurements from Planck data

The CMB temperature-redshift relation, T_CMB(z)=T_0(1+z), is a key prediction of the standard cosmology, but is violated in many non standard models. Constraining possible deviations to this law is an effective way to test the LambdaCDM paradigm and to search for hints of new physics. We have determined T_CMB(z), with a precision up to 3%, for a subsample (104 clusters) of the Planck SZ cluster catalog, at redshift in the range 0.01-- 0.94, using measurements of the spectrum of the Sunyaev Zel'dovich effect obtained from Planck temperature maps at frequencies from 70 to 353 GHz. The method adopted to provide individual determinations of T_CMB(z) at cluster redshift relies on the use of SZ intensity change, Delta I_SZ(nu), at different frequencies, and on a Monte-Carlo Markov Chain approach. By applying this method to the sample of 104 clusters, we limit possible deviations of the form T_CMB(z)=T_0(1+z)^(1-beta) to be beta= 0.022 +/- 0.018, at 1 sigma uncertainty, consistent with the prediction of the standard model. Combining these measurements with previously published results we get beta=0.016+/-0.012.Comment: submitted to JCAP, 21 pages, 8 figure

Absolute calibration and beam reconstruction of MITO (a ground-based instrument in the millimetric region)

An efficient sky data reconstruction derives from a precise characterization of the observing instrument. Here we describe the reconstruction of performances of a single-pixel 4-band photometer installed at MITO (Millimeter and Infrared Testagrigia Observatory) focal plane. The strategy of differential sky observations at millimeter wavelengths, by scanning the field of view at constant elevation wobbling the subreflector, induces a good knowledge of beam profile and beam-throw amplitude, allowing efficient data recovery. The problems that arise estimating the detectors throughput by drift scanning on planets are shown. Atmospheric transmission, monitored by skydip technique, is considered for deriving final responsivities for the 4 channels using planets as primary calibrators.Comment: 14 pages, 6 fiugres, accepted for pubblication by New Astronomy (25 March

Malocclusion and rhinitis in children: an easy-going relationship or a yet to be resolved paradox? A systematic literature revision

Objective: The relation between nasal flow and malocclusion represents a practical concern to pediatricians, otorhinolaryngologists, orthodontists, allergists and speech therapists. If naso-respiratory function may influence craniofacial growth is still debated. Chronic mouth-breathing is reported to be associated also with a characteristic pattern of dental occlusion. On the other hand, also malocclusion may reduce nasal air flows promoting nasal obstruction. Hereby, the aim of this review was to describe the relationship between rhinitis and malocclusion in children. Methods: An electronic search was conducted using online database including Pubmed, Web of Science, Google Scholar and Embase. All studies published through to January 30, 2017 investigating the prevalence of malocclusion in children and adolescents (aged 0-20 years) affected by rhinitis and the prevalence of rhinitis in children with malocclusion were included. The protocol was registered at PROSPERO - International prospective register of systematic reviews under CRD42016053619. Results: Ten studies with 2733 patients were included in the analysis. The prevalence of malocclusion in children with rhinitis was specified in four of the studies ranging from as high as 78.2% to as low as 3%. Two out of the studies reported the prevalence of rhinitis in children with malocclusion with a rate ranging from 59.2 to 76.4%. Conclusion: The results of this review underline the importance of the diagnosis and treatment of the nasal obstruction at an early age to prevent an altered facial growth, but the data currently available on this topic do not allow to establish a possible causal relationship between rhinitis and malocclusion

MAD-4-MITO, a Multi Array of Detectors for ground-based mm/submm SZ observations

The last few years have seen a large development of mm technology and ultra-sensitive detectors devoted to microwave astronomy and astrophysics. The possibility to deal with large numbers of these detectors assembled into multi--pixel imaging systems has greatly improved the performance of microwave observations, even from ground--based stations, especially combining the power of multi--band detectors with their new imaging capabilities. Hereafter, we will present the development of a multi--pixel solution devoted to Sunyaev--Zel'dovich observations from ground--based telescopes, that is going to be operated from the Millimetre and Infrared Testagrigia Observatory.Comment: 5 pages, 3 figures, to be published in th eProceedings of the 2K1BC Workshop, July 9-13, 2001 - Breuil-Cervini

Triple Experiment Spectrum of the Sunyaev-Zeldovich Effect in the Coma Cluster: H_0

The Sunyaev-Zeldovich (SZ) effect was previously measured in the Coma cluster by the Owens Valley Radio Observatory and Millimeter and IR Testa Grigia Observatory experiments and recently also with the Wilkinson Microwave Anisotropy Probe satellite. We assess the consistency of these results and their implications on the feasibility of high-frequency SZ work with ground-based telescopes. The unique data set from the combined measurements at six frequency bands is jointly analyzed, resulting in a best-fit value for the Thomson optical depth at the cluster center, tau_{0}=(5.35 \pm 0.67) 10^{-3}. The combined X-ray and SZ determined properties of the gas are used to determine the Hubble constant. For isothermal gas with a \beta density profile we derive H_0 = 84 \pm 26 km/(s\cdot Mpc); the (1\sigma) error includes only observational SZ and X-ray uncertainties.Comment: 11 pages, 1 figur

Constraints on the CMB temperature redshift dependence from SZ and distance measurements

The relation between redshift and the CMB temperature, $T_{CMB}(z)=T_0(1+z)$ is a key prediction of standard cosmology, but is violated in many non-standard models. Constraining possible deviations to this law is an effective way to test the $\Lambda$CDM paradigm and search for hints of new physics. We present state-of-the-art constraints, using both direct and indirect measurements. In particular, we point out that in models where photons can be created or destroyed, not only does the temperature-redshift relation change, but so does the distance duality relation, and these departures from the standard behaviour are related, providing us with an opportunity to improve constraints. We show that current datasets limit possible deviations of the form $T_{CMB}(z)=T_0(1+z)^{1-\beta}$ to be $\beta=0.004\pm0.016$ up to a redshift $z\sim 3$. We also discuss how, with the next generation of space and ground-based experiments, these constraints can be improved by more than one order of magnitude.Comment: 27 pages, 11 figure

A influência da pressão positiva expiratória final (PEEP) associada à intervenção fisioterapêutica na fase I da reabilitação cardiovascular

PURPOSE: To evaluate the effects of positive end expiratory pressure and physiotherapy intervention during Phase I of cardiac rehabilitation on the behavior of pulmonary function and inspiratory muscle strength in postoperative cardiac surgery. METHODS: A prospective randomized study, in which 24 patients were divided in 2 groups: a group that performed respiratory exercises with positive airway expiratory pressure associated with physiotherapy intervention (GEP, n = 8) and a group that received only the physiotherapy intervention (GPI, n = 16). Pulmonary function was evaluated by spirometry on the preoperative and on the fifth postoperative days; inspiratory muscle strength was measured by maximal inspiratory pressure on the same days. RESULTS: Spirometric variables were significantly reduced from the preoperative to the fifth postoperative day for the GPI, while the GEP had a significant reduction only for vital capacity (P < .05). When the treatments were compared, smaller values were observed in the GPI for peak flow on the fifth postoperative day. Significant reductions of maximal inspiratory pressure from preoperative to the first postoperative day were found in both groups. However, the reduction in maximal inspiratory pressure from the preoperative to the fifth postoperative day was significant only in the GPI (P < .05). CONCLUSIONS: These data suggest that cardiac surgery produces a reduction in inspiratory muscle strength, pulmonary volume, and flow. The association of positive expiratory pressure with physiotherapy intervention was more efficient in minimizing these changes, in comparison to the physiotherapy intervention alone. However, in both groups, the pulmonary volumes were not completely reestablished by the fifth postoperative day, and it was necessary to continue the treatment after hospital convalescence.OBJETIVO: Avaliar os efeitos da pressão positiva expiratória final e da intervenção fisioterápica na fase I da reabilitação cardiovascular sobre o comportamento da função pulmonar e da força muscular inspiratória e sobre o pós-operatório de cirurgia cardíaca. MÉTODO: Estudo prospectivo, randomizado, com 24 pacientes, separados em 2 grupos: GEP (n=8), que realizaram exercícios respiratórios com pressão positiva expiratória nas vias aéreas associados à intervenção fisioterápica; e GFI (n=16), que realizaram somente a intervenção fisioterápica. A função pulmonar foi avaliada pela espirometria no pré e 5º dia pós-operatório; a força muscular inspiratória pela pressão inspiratória máxima no pré, 1º e 5º dias pós-operatório. RESULTADOS: As variáveis espirométricas mostraram reduções significativas do pré para o 5º dia pós-operatório no GFI, porém no GEP, observou-se redução apenas para capacidade vital (