Renal transplantation at the university of Colorado

From March 1962 to April 1963, 118 patients were treated with renal transplantation, 3 with kidneys from identical twins, 9 with cadaveric homografts, and 106 with homografts from volunteer donors. Sixty-two of the patients are still alive after nine months to almost five years. The only completely satisfactory group was that of the identical twin recipients. The results after homotransplantation have not materially improved during this time despite the acquisition of increased experience, adjustments of timing and dosage of azathioprine and prednisone, and attempts to identify biologically suitable donors in advance of operation by tissue typing. It is suggested that an impasse has been reached, beyond which further reduction in mortality and morbidity will depend primarily upon the effective application of new immunosuppressive techniques. © 1967 by The Williams and Wilkins Co

A search for interstellar anthracene toward the Perseus anomalous microwave emission region

We report the discovery of a new broad interstellar (or circumstellar) band at 7088.8 +- 2.0 \AA coincident to within the measurement uncertainties with the strongest band of the anthracene cation (C$_{14}$H$_{10}$$^+$) as measured in gas-phase laboratory spectroscopy at low temperatures (Sukhorukov et al.2004). The band is detected in the line of sight of star Cernis 52, a likely member of the very young star cluster IC 348, and is probably associated with cold absorbing material in a intervening molecular cloud of the Perseus star forming region where various experiments have recently detected anomalous microwave emission. From the measured intensity and available oscillator strength we find a column density of N$_{an^+}$= 1.1(+-0.4) x 10$^{13}$ cm$^{-2}$ implying that ~0.008% of the carbon in the cloud could be in the form of C$_{14}$H$_{10}$$^+$. A similar abundance has been recently claimed for the naphthalene cation (Iglesias-Groth et al. 2008) in this cloud. This is the first location outside the Solar System where specific PAHs are identified. We report observations of interstellar lines of CH and CH$^+$ that support a rather high column density for these species and for molecular hydrogen. The strength ratio of the two prominent diffuse interstellar bands at 5780 and 5797 \AA suggests the presence of a ``zeta'' type cloud in the line of sight (consistent with steep far-UV extinction and high molecular content). The presence of PAH cations and other related hydrogenated carbon molecules which are likely to occur in this type of clouds reinforce the suggestion that electric dipole radiation from fast spinning PAHs is responsible of the anomalous microwave emission detected toward Perseus.Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Societ

Verifiable Elections That Scale for Free

In order to guarantee a fair and transparent voting process, electronic voting schemes must be verifiable. Most of the time, however, it is important that elections also be anonymous. The notion of a verifiable shuffle describes how to satisfy both properties at the same time: ballots are submitted to a public bulletin board in encrypted form, verifiably shuffled by several mix servers (thus guaranteeing anonymity), and then verifiably decrypted by an appropriate threshold decryption mechanism. To guarantee transparency, the intermediate shuffles and decryption results, together with proofs of their correctness, are posted on the bulletin board throughout this process. In this paper, we present a verifiable shuffle and threshold decryption scheme in which, for security parameter k, L voters, M mix servers, and N decryption servers, the proof that the end tally corresponds to the original encrypted ballots is only O(k(L + M + N)) bits long. Previous verifiable shuffle constructions had proofs of size O(kLM + kLN), which, for elections with thousands of voters, mix servers, and decryption servers, meant that verifying an election on an ordinary computer in a reasonable amount of time was out of the question. The linchpin of each construction is a controlled-malleable proof (cm-NIZK), which allows each server, in turn, to take a current set of ciphertexts and a proof that the computation done by other servers has proceeded correctly so far. After shuffling or partially decrypting these ciphertexts, the server can also update the proof of correctness, obtaining as a result a cumulative proof that the computation is correct so far. In order to verify the end result, it is therefore sufficient to verify just the proof produced by the last server

Evidence for the naphthalene cation in a region of the interstellar medium with anomalous microwave emission

We report high resolution spectroscopy of the moderately reddened (A$_V$=3) early type star Cernis 52 located in a region of the Perseus molecular cloud complex with anomalous microwave emission. In addition to the presence of the most common diffuse interstellar bands (DIBs) we detect two new interstellar or circumstellar bands coincident to within 0.01% in wavelength with the two strongest bands of the naphthalene cation (C$_{10}$H$_{8}^+$) as measured in gas-phase laboratory spectroscopy at low temperatures and find marginal evidence for the third strongest band. Assuming these features are caused by the naphthalene cation, from the measured intensity and available oscillator strengths we find that 0.008 % of the carbon in the cloud could be in the form of this molecule. We expect hydrogen additions to cause hydronaphthalene cations to be abundant in the cloud and to contribute via electric dipole radiation to the anomalous microwave emission. The identification of new interstellar features consistent with transitions of the simplest polycyclic aromatic hydrocarbon adds support to the hypothesis that this type of molecules are the carriers of both diffuse interstellar bands and anomalous microwave emission.Comment: Accepted for publication in The Astrophysical Journa

A Simulation Environment and Reinforcement Learning Method for Waste Reduction

In retail (e.g., grocery stores, apparel shops, online retailers), inventory managers have to balance short-term risk (no items to sell) with long-term-risk (over ordering leading to product waste). This balancing task is made especially hard due to the lack of information about future customer purchases. In this paper, we study the problem of restocking a grocery store’s inventory with perishable items over time, from a distributional point of view. The objective is to maximize sales while minimizing waste, with uncertainty about the actual consumption by costumers. This problem is of a high relevance today, given the growing demand for food and the impact of food waste on the environment, the economy, and purchasing power. We frame inventory restocking as a new reinforcement learning task that exhibits stochastic behavior conditioned on the agent’s actions, making the environment partially observable. We make two main contributions. First, we introduce a new reinforcement learning environment, RetaiL, based on real grocery store data and expert knowledge. This environment is highly stochastic, and presents a unique challenge for reinforcement learning practitioners. We show that uncertainty about the future behavior of the environment is not handled well by classical supply chain algorithms, and that distributional approaches are a good way to account for the uncertainty. Second, we introduce GTDQN, a distributional reinforcement learning algorithm that learns a generalized lambda distribution over the reward space. GTDQN provides a strong baseline for our environment. It outperforms other distributional reinforcement learning approaches in this partially observable setting, in both overall reward and generated waste

A Simulation Environment and Reinforcement Learning Method for Waste Reduction

In retail (e.g., grocery stores, apparel shops, online retailers), inventory managers have to balance short-term risk (no items to sell) with long-term-risk (over ordering leading to product waste). This balancing task is made especially hard due to the lack of information about future customer purchases. In this paper, we study the problem of restocking a grocery store’s inventory with perishable items over time, from a distributional point of view. The objective is to maximize sales while minimizing waste, with uncertainty about the actual consumption by costumers. This problem is of a high relevance today, given the growing demand for food and the impact of food waste on the environment, the economy, and purchasing power. We frame inventory restocking as a new reinforcement learning task that exhibits stochastic behavior conditioned on the agent’s actions, making the environment partially observable. We make two main contributions. First, we introduce a new reinforcement learning environment, RetaiL, based on real grocery store data and expert knowledge. This environment is highly stochastic, and presents a unique challenge for reinforcement learning practitioners. We show that uncertainty about the future behavior of the environment is not handled well by classical supply chain algorithms, and that distributional approaches are a good way to account for the uncertainty. Second, we introduce GTDQN, a distributional reinforcement learning algorithm that learns a generalized lambda distribution over the reward space. GTDQN provides a strong baseline for our environment. It outperforms other distributional reinforcement learning approaches in this partially observable setting, in both overall reward and generated waste

Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes

The existence of four subpopulations in resting porcine T lymphocytes is documented. In addition to the two known subpopulations which are typified by a mutually exclusive expression of either the CD8 or the CD4 differentiation antigen, CD4-CD8+ and CD4+CD8- T lymphocytes, respectively, two unusual subpopulations were prominent not only in peripheral blood, but also in lymphoid tissues: CD4-CD8- T lymphocytes expressing neither of these antigens and CD4+CD8+ T lymphocytes coexpressing both antigens. While CD4+CD8+ lymphoblasts have been found also in other species, resting T lymphocytes with that phenotype are without precedent among all species analyzed to date. This unique composition of the porcine T lymphocyte population has to be taken into consideration when the swine is used as a large animal model in experimental medicine

Succinct Malleable NIZKs and an Application to Compact Shuffles

Depending on the application, malleability in cryptography can be viewed as either a flaw or — especially if sufficiently understood and restricted — a feature. In this vein, Chase, Kohlweiss, Lysyanskaya, and Meiklejohn recently defined malleable zero-knowledge proofs, and showed how to control the set of allowable transformations on proofs. As an application, they construct the first compact verifiable shuffle, in which one such controlled-malleable proof suffices to prove the correctness of an entire multi-step shuffle. Despite these initial steps, a number of natural open problems remain: (1) their construction of controlled-malleable proofs relies on the inherent malleability of Groth-Sahai proofs and is thus not based on generic primitives; (2) the classes of allowable transformations they can support are somewhat restrictive; and (3) their construction of a compactly verifiable shuffle has proof size O(N 2 + L) (where N is the number of votes and L is the number of mix authorities), whereas in theory such a proof could be of size O(N + L). In this paper, we address these open problems by providing a generic construction of controlledmalleable proofs using succinct non-interactive arguments of knowledge, or SNARGs for short. Our construction has the advantage that we can support a very general class of transformations (as we no longer rely on the transformations that Groth-Sahai proofs can support), and that we can use it to obtain a proof of size O(N + L) for the compactly verifiable shuffle

The Avidity Spectrum of T Cell Receptor Interactions Accounts for T Cell Anergy in a Double Transgenic Model

The mechanism of self-tolerance in the CD4+ T cell compartment was examined in a double transgenic (Tg) model in which T cell receptor (TCR)-α/β Tg mice with specificity for the COOH-terminal peptide of moth cytochrome c in association with I-Ek were crossed with antigen Tg mice. Partial deletion of cytochrome-reactive T cells in the thymus allowed some self-specific CD4+ T cells to be selected into the peripheral T cell pool. Upon restimulation with peptide in vitro, these cells upregulated interleukin (IL)-2 receptor but showed substantially lower cytokine production and proliferation than cells from TCR Tg controls. Proliferation and cytokine production were restored to control levels by addition of saturating concentrations of IL-2, consistent with the original in vitro definition of T cell anergy. However, the response of double Tg cells to superantigen stimulation in the absence of exogenous IL-2 was indistinguishable from that of TCR Tg controls, indicating that these self-reactive cells were not intrinsically hyporesponsive. Measurement of surface expression of Tg-encoded TCR α and β chains revealed that cells from double Tg mice expressed the same amount of TCR-β as cells from TCR Tg controls, but only 50% of TCR-α, implying expression of more than one α chain. Naive CD4+ T cells expressing both Tg-encoded and endogenous α chains also manifested an anergic phenotype upon primary stimulation with cytochrome c in vitro, suggesting that low avidity for antigen can produce an anergic phenotype in naive cells. The carboxyfluorescein diacetate succinimidyl ester cell division profiles in response to titered peptide ± IL-2 indicated that expression of IL-2 receptor correlated with peptide concentration but not TCR level, whereas IL-2 production was profoundly affected by the twofold decrease in specific TCR expression. Addition of exogenous IL-2 recruited double Tg cells into division, resulting in a pattern of cell division indistinguishable from that of controls. Thus, in this experimental model, cells expressing more than one α chain escaped negative selection to a soluble self-protein in the thymus and had an anergic phenotype indistinguishable from that of low avidity naive cells. The data are consistent with the notion that avidity-mediated selection for self-reactivity in the thymus may lead to the appearance of anergy within the peripheral, self-reactive T cell repertoire, without invoking the induction of hyporesponsiveness to TCR-mediated signals