Rural indebtedness : concept, correlates and consequences: a study of four tribal villages in the North Lakhimpur subdivision, Assam

Indebtedness has been acknowledged as one of the most infamous stumbling blocks in the way of rural prosperity. It is cancerous, self-perpetuating, malignant and maleficent. It abates agricultural production, abashes social psyche, aggravates inequalities in the distribution of socioeconomic opportunities and benefits, arrests social progress and misdirects social efforts. In the Indian rural context, indebtedness characterizes: (i). unproductive usage of loan, (ii). usurious ensnaring of the borrower, (iii). captivation of productive resources, (iv). exercise of coercive and exploitative economic and social powers by the lender, (v). compulsion, plight, misery and feeling of guilt and helplessness, and (vi). erosion of social status of the borrower. In this study we propose an empirical study to measure indebtedness, identify its correlates and to assess the consequences of indebtedness on the productive and distributive performance on the rural economy. We have collected primary data from four tribal villages. The selection of these villages has been made purposively. We hold the opinion that the tribal population in the rural areas of Assam has been least exposed to the credit programmes launched by the public agencies and hence a study of indebtedness provides us with a deeper insight in the problem. We have observed that in the Indian context rural indebtedness is resonant with the overtones of unproductive usage, usurious ensnaring and deplorable condition of the poor farmers and agricultural labourers. We have surveyed four tribal villages and based on the data thus collected identified some measures of indebtedness that can help us operationally in analyzing the incidence, process and impacts of rural indebtedness. These measures are per capita loan and per capita loan per agricultural asset held by the households and these measures are good representatives of the degree of indebtedness. We have analyzed the productive and distributive effects of indebtedness and found that it leads to decline in agricultural productivity, captivation of productive resources and aggravation of inequalities in the rural community. Further, our finding is that indebtedness is initiated by unproductive expenditure. This in turn captivates agricultural assets, abates productivity and reduces the repaying capacity of the borrower. Our study may suggest that in order to ameliorate the conditions of the indebted rural mass we have to motivate them to minimize conspicuous consumption, especially if the households cannot afford it without borrowing. Educational planning may help us to attain this goal of making the rural mass aware of the merits of prudence and the demerits of conspicuous consumption. Further, to stop the captivation of productive assets, institutional loan should be provided on easy terms. This objective may be attained by making the cooperative and bank loans easily available.Rural indebtedness; correlates; consequences; measures of incidence; distributive effects; causal chain; Assam; primary data; tribal villages; poverty

Influence of enhanced Asian NOx emissions on ozone in the upper troposphere and lower stratosphere in chemistry–climate model simulations

The Asian summer monsoon (ASM) anticyclone is the most pronounced circulation pattern in the upper troposphere and lower stratosphere (UTLS) during northern hemispheric summer. ASM convection plays an important role in efficient vertical transport from the surface to the upper-level anticyclone. In this paper we investigate the potential impact of enhanced anthropogenic nitrogen oxide (NOx) emissions on the distribution of ozone in the UTLS using the fully coupled aerosol–chemistry–climate model, ECHAM5-HAMMOZ. Ozone in the UTLS is influenced both by the convective uplift of ozone precursors and by the uplift of enhanced-NOx-induced tropospheric ozone anomalies. We performed anthropogenic NOx emission sensitivity experiments over India and China. In these simulations, covering the years 2000–2010, anthropogenic NOx emissions have been increased by 38 % over India and by 73 % over China with respect to the emission base year 2000. These emission increases are comparable to the observed linear trends of 3.8 % per year over India and 7.3 % per year over China during the period 2000 to 2010. Enhanced NOx emissions over India by 38 % and China by 73 % increase the ozone radiative forcing in the ASM anticyclone (15–40° N, 60–120° E) by 16.3 and 78.5 mW m−2 respectively. These elevated NOx emissions produce significant warming over the Tibetan Plateau and increase precipitation over India due to a strengthening of the monsoon Hadley circulation. However, increase in NOx emissions over India by 73 % (similar to the observed increase over China) results in large ozone production over the Indo-Gangetic Plain and Tibetan Plateau. The higher ozone concentrations, in turn, induce a reversed monsoon Hadley circulation and negative precipitation anomalies over India. The associated subsidence suppresses vertical transport of NOx and ozone into the ASM anticyclone

The Production of Antibody by Invading B Cells Is Required for the Clearance of Rabies Virus from the Central Nervous System

Every year over 50,000 people die from rabies worldwide, primarily due to the poor availability of rabies vaccine in developing countries. However, even when vaccines are available, human deaths from rabies occur if exposure to the causative virus is not recognized and vaccination is not sought in time. This is because rabies virus immunity induced by the natural infection or current vaccines is generally not effective at removing disease-causing rabies virus from brain tissues. Our studies provide insight into why this is the case and how vaccination can be changed so that the immune response can clear the virus from brain tissues. We show that the type of immune response induced by a live-attenuated rabies virus vaccine may be the key. In animal models, live-attenuated rabies virus vaccines are effective at delivering the immune cells capable of clearing the virus into CNS tissues and promote recovery from a rabies virus infection that has spread to the brain while conventional vaccines based on killed rabies virus do not. The production of rabies-specific antibody by B cells that invade the CNS tissues is important for complete elimination of the virus. We hypothesize that similar mechanisms may promote rabies virus clearance from individuals who are diagnosed after the virus has reached, but not extensively spread, through the CNS

MENTORING PRACTICES IN PNU PARTNER SCHOOLS : TOWARDS POLICY CREATION IN CAPACITY BUILDING OF COOPERATING TEACHERS FOR EFFECTIVE MENTORING

The practice of mentoring student teachers seeks the much needed intervention and reform in the preparation of future teacher professionals who will eventually implement the K-12 Curriculum in the Philippines. The present study investigated on the perception of student teachers on the way they were mentored during their practice teaching in the selected partner schools. Additionally, this paper presents the beliefs and practices of cooperating teachers which student teachers perceive to be effective in the mentoring process. Data gathered from surveys and interviews with student teachers and cooperating teachers for this study pointed the strengths of the mentoring program as well as pitfalls that need to be addressed. The cooperating teachers in the different partner schools identified elements which are believed to be areas of concern that make them feel the need to undergo capability building. The findings presented here are intended to inform the development of policies in building cooperating teachers‟ capability for effective mentoring

Rural indebtedness : concept, correlates and consequences: a study of four tribal villages in the North Lakhimpur subdivision, Assam

Indebtedness has been acknowledged as one of the most infamous stumbling blocks in the way of rural prosperity. It is cancerous, self-perpetuating, malignant and maleficent. It abates agricultural production, abashes social psyche, aggravates inequalities in the distribution of socioeconomic opportunities and benefits, arrests social progress and misdirects social efforts. In the Indian rural context, indebtedness characterizes: (i). unproductive usage of loan, (ii). usurious ensnaring of the borrower, (iii). captivation of productive resources, (iv). exercise of coercive and exploitative economic and social powers by the lender, (v). compulsion, plight, misery and feeling of guilt and helplessness, and (vi). erosion of social status of the borrower. In this study we propose an empirical study to measure indebtedness, identify its correlates and to assess the consequences of indebtedness on the productive and distributive performance on the rural economy. We have collected primary data from four tribal villages. The selection of these villages has been made purposively. We hold the opinion that the tribal population in the rural areas of Assam has been least exposed to the credit programmes launched by the public agencies and hence a study of indebtedness provides us with a deeper insight in the problem. We have observed that in the Indian context rural indebtedness is resonant with the overtones of unproductive usage, usurious ensnaring and deplorable condition of the poor farmers and agricultural labourers. We have surveyed four tribal villages and based on the data thus collected identified some measures of indebtedness that can help us operationally in analyzing the incidence, process and impacts of rural indebtedness. These measures are per capita loan and per capita loan per agricultural asset held by the households and these measures are good representatives of the degree of indebtedness. We have analyzed the productive and distributive effects of indebtedness and found that it leads to decline in agricultural productivity, captivation of productive resources and aggravation of inequalities in the rural community. Further, our finding is that indebtedness is initiated by unproductive expenditure. This in turn captivates agricultural assets, abates productivity and reduces the repaying capacity of the borrower. Our study may suggest that in order to ameliorate the conditions of the indebted rural mass we have to motivate them to minimize conspicuous consumption, especially if the households cannot afford it without borrowing. Educational planning may help us to attain this goal of making the rural mass aware of the merits of prudence and the demerits of conspicuous consumption. Further, to stop the captivation of productive assets, institutional loan should be provided on easy terms. This objective may be attained by making the cooperative and bank loans easily available

Rural indebtedness : concept, correlates and consequences: a study of four tribal villages in the North Lakhimpur subdivision, Assam

Indebtedness has been acknowledged as one of the most infamous stumbling blocks in the way of rural prosperity. It is cancerous, self-perpetuating, malignant and maleficent. It abates agricultural production, abashes social psyche, aggravates inequalities in the distribution of socioeconomic opportunities and benefits, arrests social progress and misdirects social efforts. In the Indian rural context, indebtedness characterizes: (i). unproductive usage of loan, (ii). usurious ensnaring of the borrower, (iii). captivation of productive resources, (iv). exercise of coercive and exploitative economic and social powers by the lender, (v). compulsion, plight, misery and feeling of guilt and helplessness, and (vi). erosion of social status of the borrower. In this study we propose an empirical study to measure indebtedness, identify its correlates and to assess the consequences of indebtedness on the productive and distributive performance on the rural economy. We have collected primary data from four tribal villages. The selection of these villages has been made purposively. We hold the opinion that the tribal population in the rural areas of Assam has been least exposed to the credit programmes launched by the public agencies and hence a study of indebtedness provides us with a deeper insight in the problem. We have observed that in the Indian context rural indebtedness is resonant with the overtones of unproductive usage, usurious ensnaring and deplorable condition of the poor farmers and agricultural labourers. We have surveyed four tribal villages and based on the data thus collected identified some measures of indebtedness that can help us operationally in analyzing the incidence, process and impacts of rural indebtedness. These measures are per capita loan and per capita loan per agricultural asset held by the households and these measures are good representatives of the degree of indebtedness. We have analyzed the productive and distributive effects of indebtedness and found that it leads to decline in agricultural productivity, captivation of productive resources and aggravation of inequalities in the rural community. Further, our finding is that indebtedness is initiated by unproductive expenditure. This in turn captivates agricultural assets, abates productivity and reduces the repaying capacity of the borrower. Our study may suggest that in order to ameliorate the conditions of the indebted rural mass we have to motivate them to minimize conspicuous consumption, especially if the households cannot afford it without borrowing. Educational planning may help us to attain this goal of making the rural mass aware of the merits of prudence and the demerits of conspicuous consumption. Further, to stop the captivation of productive assets, institutional loan should be provided on easy terms. This objective may be attained by making the cooperative and bank loans easily available

A Combined Laboratory and Synchrotron In-Situ Photoemission Study of the Rutile TiO2 (110) / Water Interface

In-situ analysis of the TiO2 / water interface via NAP-XPS is demonstrated in both a lab based system (NAP-cell configuration) and synchrotron endstation (backfill configuration). Ultra-thin wetting layers (UTWL) of liquid water (~10 nm) are formed on a rutile TiO2 surface with minimal contamination present in addition to unique insight during the growth of the liquid films as indicated via NAP-XPS, in-situ sample temperature and background vapour pressure monitoring. Chemical changes at the solid / liquid interface are also demonstrated via healing of Ti3+ surface defect states. Photon depth profiling of the as grown liquid layers indicate that the formed films are ultra-thin (~10 nm) and likely to be continuous in nature. This work demonstrates a novel and flexible approach for studying the solid / liquid interface via NAP-XPS which is readily integrated with any form of NAP-XPS system, thereby making a critical interface of study available to a wide audience of researchers for use in operando electrochemical and photocatalytic research

Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.

In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation. However, other genes downstream of the Onecut proteins and involved in motor neuron diversification have remained unidentified. In the present study, we generated conditional mutant embryos carrying specific inactivation of Onecut genes in the developing motor neurons, performed RNA-sequencing to identify factors downstream of Onecut proteins in this neuron population, and employed additional transgenic mouse models to assess the role of one specific Onecut-downstream target, the transcription factor Nkx6.2. Nkx6.2 expression was up-regulated in Onecut-deficient motor neurons, but strongly downregulated in Onecut-deficient V2a interneurons, indicating an opposite regulation of Nkx6.2 by Onecut factors in distinct spinal neuron populations. Nkx6.2-null embryos, neonates and adult mice exhibited alterations of locomotor pattern and spinal locomotor network activity, likely resulting from defective survival of a subset of limb-innervating motor neurons and abnormal migration of V2a interneurons. Taken together, our results indicate that Nkx6.2 regulates the development of spinal neuronal populations and the formation of the spinal locomotor circuits downstream of the Onecut transcription factors

Do Web-based Mental Health Literacy Interventions Improve the Mental Health Literacy of Adult Consumers? Results From a Systematic Review

Background: Low levels of mental health literacy (MHL) have been identified as an important contributor to the mental health treatment gap. Interventions to improve MHL have used traditional media (eg, community talks, print media) and new platforms (eg, the Internet). Evaluations of interventions using conventional media show improvements in MHL improve community recognition of mental illness as well as knowledge, attitude, and intended behaviors toward people having mental illness. However, the potential of new media, such as the Internet, to enhance MHL has yet to be systematically evaluated. Objective: Study aims were twofold: (1) To systematically appraise the efficacy of Web-based interventions in improving MHL. (2) To establish if increases in MHL translated into improvement in individual health seeking and health outcomes as well as reductions in stigma toward people with mental illness. Methods: We conducted a systematic search and appraisal of all original research published between 2000 and 2015 that evaluated Web-based interventions to improve MHL. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were used to report findings. Results: Fourteen studies were included: 10 randomized controlled trials and 4 quasi-experimental studies. Seven studies were conducted in Australia. A variety of Web-based interventions were identified ranging from linear, static websites to highly interactive interventions such as social media games. Some Web-based interventions were specifically designed for people living with mental illness whereas others were applicable to the general population. Interventions were more likely to be successful if they included “active ingredients” such as a structured program, were tailored to specific populations, delivered evidenced-based content, and promoted interactivity and experiential learning.Conclusions: Web-based interventions targeting MHL are more likely to be successful if they include active ingredients. Improvements in MHL see concomitant improvements in health outcomes, especially for individuals with mild to moderate depression. The most promising interventions suited to this cohort appear to be MoodGYM and BluePages, 2 interventions from Australia. However, the relationship between MHL and formal and informal help seeking is less clear; self-stigma appears to be an important mediator with results showing that despite improvements in MHL and community attitudes to mental illness, individuals with mental illness still seek help at relatively low rates. Overall, the Internet is a viable method to improve MHL. Future studies could explore how new technology interfaces (eg, mobile phones vs computers) can help improve MHL, mental health outcomes, and reduce stigma

Combination disease-modifying treatment in spinal muscular atrophy: A proposed classification

We sought to devise a rational, systematic approach for defining/grouping survival motor neuron-targeted disease-modifying treatment (DMT) scenarios. The proposed classification is primarily based on a two-part differentiation: initial DMT, and persistence/discontinuation of subsequent DMT(s). Treatment categories were identified: monotherapy add-on, transient add-on, combination with onasemnogene abeparvovec, bridging to onasemnogene abeparvovec, and switching to onasemnogene abeparvovec. We validated this approach by applying the classification to the 443 patients currently in the RESTORE registry and explored the demographics of these different groups of patients. This work forms the basis to explore the safety and efficacy profile of the different combinations of DMT in SMA