2,310 research outputs found
Universal scaling relation in high-temperature superconductors
Scaling laws express a systematic and universal simplicity among complex
systems in nature. For example, such laws are of enormous significance in
biology. Scaling relations are also important in the physical sciences. The
seminal 1986 discovery of high transition-temperature (high-T_c)
superconductivity in cuprate materials has sparked an intensive investigation
of these and related complex oxides, yet the mechanism for superconductivity is
still not agreed upon. In addition, no universal scaling law involving such
fundamental properties as T_c and the superfluid density \rho_s, a quantity
indicative of the number of charge carriers in the superconducting state, has
been discovered. Here we demonstrate that the scaling relation \rho_s \propto
\sigma_{dc} T_c, where the conductivity \sigma_{dc} characterizes the
unidirectional, constant flow of electric charge carriers just above T_c,
universally holds for a wide variety of materials and doping levels. This
surprising unifying observation is likely to have important consequences for
theories of high-T_c superconductivity.Comment: 11 pages, 2 figures, 2 table
Algorithms for Cut Problems on Trees
We study the {\sc multicut on trees} and the {\sc generalized multiway Cut on
trees} problems. For the {\sc multicut on trees} problem, we present a
parameterized algorithm that runs in time , where is the positive root of the polynomial
. This improves the current-best algorithm of Chen et al. that runs
in time . For the {\sc generalized multiway cut on trees}
problem, we show that this problem is solvable in polynomial time if the number
of terminal sets is fixed; this answers an open question posed in a recent
paper by Liu and Zhang. By reducing the {\sc generalized multiway cut on trees}
problem to the {\sc multicut on trees} problem, our results give a
parameterized algorithm that solves the {\sc generalized multiway cut on trees}
problem in time , where time
Reporting and evaluating genetic association studies
Genetic association studies have become an important part of our scientific landscape. This commentary discusses some basic scientific issues which should be considered when reporting and evaluating such studies including SNP Discovery, Genotyping and Haplotype Analysis; Population Size, Matching of Cases and Controls, and Population Stratification; Phenotype Definition and Multiple Related Phenotypes; Multiple Testing; Replication; Genome-wide Association Studies (GWAS); and the Role of Functional Studies. All of these elements are important in evaluating such studies and should be carefully considered when these studies are conceived and carried out
Recommended from our members
SEIS: Insight's Seismic Experiment for Internal Structure of Mars.
By the end of 2018, 42 years after the landing of the two Viking seismometers on Mars, InSight will deploy onto Mars' surface the SEIS (Seismic Experiment for Internal Structure) instrument; a six-axes seismometer equipped with both a long-period three-axes Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These six sensors will cover a broad range of the seismic bandwidth, from 0.01 Hz to 50 Hz, with possible extension to longer periods. Data will be transmitted in the form of three continuous VBB components at 2 sample per second (sps), an estimation of the short period energy content from the SP at 1 sps and a continuous compound VBB/SP vertical axis at 10 sps. The continuous streams will be augmented by requested event data with sample rates from 20 to 100 sps. SEIS will improve upon the existing resolution of Viking's Mars seismic monitoring by a factor of ∼ 2500 at 1 Hz and ∼ 200 000 at 0.1 Hz. An additional major improvement is that, contrary to Viking, the seismometers will be deployed via a robotic arm directly onto Mars' surface and will be protected against temperature and wind by highly efficient thermal and wind shielding. Based on existing knowledge of Mars, it is reasonable to infer a moment magnitude detection threshold of M w ∼ 3 at 40 ∘ epicentral distance and a potential to detect several tens of quakes and about five impacts per year. In this paper, we first describe the science goals of the experiment and the rationale used to define its requirements. We then provide a detailed description of the hardware, from the sensors to the deployment system and associated performance, including transfer functions of the seismic sensors and temperature sensors. We conclude by describing the experiment ground segment, including data processing services, outreach and education networks and provide a description of the format to be used for future data distribution.Electronic supplementary materialThe online version of this article (10.1007/s11214-018-0574-6) contains supplementary material, which is available to authorized users
Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in <i>C. elegans</i>
Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra. Disease loci causing hereditary forms of PD are known, but most cases are attributable to a combination of genetic and environmental risk factors. Increased incidence of PD is associated with rural living and pesticide exposure, and dopaminergic neurodegeneration can be triggered by neurotoxins such as 6-hydroxydopamine (6-OHDA). In C. elegans, this drug is taken up by the presynaptic dopamine reuptake transporter (DAT-1) and causes selective death of the eight dopaminergic neurons of the adult hermaphrodite. Using a forward genetic approach to find genes that protect against 6-OHDA-mediated neurodegeneration, we identified tsp-17, which encodes a member of the tetraspanin family of membrane proteins. We show that TSP-17 is expressed in dopaminergic neurons and provide genetic, pharmacological and biochemical evidence that it inhibits DAT-1, thus leading to increased 6-OHDA uptake in tsp-17 loss-of-function mutants. TSP-17 also protects against toxicity conferred by excessive intracellular dopamine. We provide genetic and biochemical evidence that TSP-17 acts partly via the DOP-2 dopamine receptor to negatively regulate DAT-1. tsp-17 mutants also have subtle behavioral phenotypes, some of which are conferred by aberrant dopamine signaling. Incubating mutant worms in liquid medium leads to swimming-induced paralysis. In the L1 larval stage, this phenotype is linked to lethality and cannot be rescued by a dop-3 null mutant. In contrast, mild paralysis occurring in the L4 larval stage is suppressed by dop-3, suggesting defects in dopaminergic signaling. In summary, we show that TSP-17 protects against neurodegeneration and has a role in modulating behaviors linked to dopamine signaling
Past Achievements and Future Challenges in 3D Photonic Metamaterials
Photonic metamaterials are man-made structures composed of tailored micro- or
nanostructured metallo-dielectric sub-wavelength building blocks that are
densely packed into an effective material. This deceptively simple, yet
powerful, truly revolutionary concept allows for achieving novel, unusual, and
sometimes even unheard-of optical properties, such as magnetism at optical
frequencies, negative refractive indices, large positive refractive indices,
zero reflection via impedance matching, perfect absorption, giant circular
dichroism, or enhanced nonlinear optical properties. Possible applications of
metamaterials comprise ultrahigh-resolution imaging systems, compact
polarization optics, and cloaking devices. This review describes the
experimental progress recently made fabricating three-dimensional metamaterial
structures and discusses some remaining future challenges
Behavioral Modernity and the Cultural Transmission of Structured Information: The Semantic Axelrod Model
Cultural transmission models are coming to the fore in explaining increases
in the Paleolithic toolkit richness and diversity. During the later
Paleolithic, technologies increase not only in terms of diversity but also in
their complexity and interdependence. As Mesoudi and O'Brien (2008) have shown,
selection broadly favors social learning of information that is hierarchical
and structured, and multiple studies have demonstrated that teaching within a
social learning environment can increase fitness. We believe that teaching also
provides the scaffolding for transmission of more complex cultural traits.
Here, we introduce an extension of the Axelrod (1997} model of cultural
differentiation in which traits have prerequisite relationships, and where
social learning is dependent upon the ordering of those prerequisites. We
examine the resulting structure of cultural repertoires as learning
environments range from largely unstructured imitation, to structured teaching
of necessary prerequisites, and we find that in combination with individual
learning and innovation, high probabilities of teaching prerequisites leads to
richer cultural repertoires. Our results point to ways in which we can build
more comprehensive explanations of the archaeological record of the Paleolithic
as well as other cases of technological change.Comment: 24 pages, 7 figures. Submitted to "Learning Strategies and Cultural
Evolution during the Paleolithic", edited by Kenichi Aoki and Alex Mesoudi,
and presented at the 79th Annual Meeting of the Society for American
Archaeology, Austin TX. Revised 5/14/1
Ab initio alpha-alpha scattering
Processes involving alpha particles and alpha-like nuclei comprise a major
part of stellar nucleosynthesis and hypothesized mechanisms for thermonuclear
supernovae. In an effort towards understanding alpha processes from first
principles, we describe in this letter the first ab initio calculation of
alpha-alpha scattering. We use lattice effective field theory to describe the
low-energy interactions of nucleons and apply a technique called the adiabatic
projection method to reduce the eight-body system to an effective two-cluster
system. We find good agreement between lattice results and experimental phase
shifts for S-wave and D-wave scattering. The computational scaling with
particle number suggests that alpha processes involving heavier nuclei are also
within reach in the near future.Comment: 6 pages, 6 figure
- …