Sulfate and MSA in the air and snow on the Greenland Ice Sheet

Sulfate and methanesulfonic acid (MSA) concentrations in aerosol, surface snow, and snowpit samples have been measured at two sites on the Greenland Ice Sheet. Seasonal variations of the concentrations observed for these chemical species in the atmosphere are reproduced in the surface snow and preserved in the snowpit sequence. The amplitude of the variations over a year are smaller in the snow than in the air, but the ratios of the concentrations are comparable. The seasonal variations for sulfate are different at the altitude of the Ice Sheet compared to those observed at sea level, with low concentrations in winter and short episodes of elevated concentrations in spring. In contrast, the variations in concentrations of MSA are similar to those measured at sea level, with a first sequence of elevated concentrations in spring and another one during summer, and a winter low resulting from low biogenic production. The ratio MSA/sulfate clearly indicates the influence of high-latitude sources for the summer maximum of MSA, but the large impact of anthropogenic sulfate precludes any conclusion for the spring maximum. The seasonal pattern observed for these species in a snowpit sampled according to stratigraphy indicates a deficit in the accumulation of winter snow at the summit of the Greenland Ice Sheet, in agreement with some direct observations. A deeper snowpit covering the years 1985–1992 indicates the consistency of the seasonal pattern for MSA over the years, which may be linked to transport and deposition processes

Evidence for a Functional Interaction between Integrins and G Protein-activated Inward Rectifier K+ Channels

Heteromultimeric G protein-activated inward rectifier K+ (GIRK) channels, abundant in heart and brain, help to determine the cellular membrane potential as well as the frequency and duration of electrical impulses. The sequence arginine-glycine-aspartate (RGD), located extracellularly between the first membrane-spanning region and the pore, is conserved among all identified GIRK subunits but is not found in the extracellular domain of any other cloned K+ channels. Many integrins, which, like channels, are integral membrane proteins, recognize this RGD sequence on other proteins, usually in the extracellular matrix. We therefore asked whether GIRK activity might be regulated by direct interaction with integrin. Here, we present evidence that mutation of the RGD site to RGE, particularly on the GIRK4 subunit, decreases or abolishes GIRK current. Furthermore, wild-type channels can be co-immunoprecipitated with integrin. The total cellular amount of expressed mutant GIRK channel protein is the same as the wild-type protein; however, the amount of mutant channel protein that localizes to the plasma membrane is decreased relative to wild-type, most likely accounting for the diminished GIRK current detected. GIRK channels appear to bind directly to integrin and to require this interaction for proper GIRK channel membrane localization and function

A comparison of soil moisture characteristics predicted by the Arya-Paris model with laboratory-measured data

Soil moisture characteristics predicted by the Arya-Paris model were compared with the laboratory measured data for 181 New Jersey soil horizons. For a number of soil horizons, the predicted and the measured moisture characteristic curves are almost coincident; for a large number of other horizons, despite some disparity, their shapes are strikingly similar. Uncertainties in the model input and laboratory measurement of the moisture characteristic are indicated, and recommendations for additional experimentation and testing are made

A modal model for diffraction gratings

A description of an algorithm for a rather general modal grating calculation is presented. Arbitrary profiles, depth, and permittivity are allowed. Gratings built up from sub-gratings are allowed, as are coatings on the sidewalls of lines, and arbitrary complex structure. Conical angles and good conductors are supported

The eta-photon transition form factor

The eta-photon transition form factor is evaluated in a formalism based on a phenomenological description at low values of the photon virtuality, and a QCD-based description at high photon virtualities, matching at a scale $Q_{0}^{2}$. The high photon virtuality description makes use of a Distribution Amplitude calculated in the Nambu-Jona-Lasinio model with Pauli-Villars regularization at the matching scale $Q_{0}^{2}$, and QCD evolution from $Q_{0}^{2}$ to higher values of $Q^{2}$. A good description of the available data is obtained. The analysis indicates that the recent data from the BaBar collaboration on pion and eta transition form factor can be well reproduced, if a small contribution of twist three at the matching scale $Q_{0}^{2}$ is included.Comment: 14 pages, 3 figures, revised version, minor corrections, references added, conclusions unchanged. Accepted for publication in Phys. Rev.

Can altering the structure of financial support payments aid work retention amongst lone parents? Qualitative evaluation of the In Work Retention Pilot

Wage supplementations in the form of temporary ‘in-work credits’ have been introduced in recent years for a number of claimant groups entering work, to encourage enhanced work entry and retention rates. For lone parents, the In Work Credit was piloted from April 2004 and then rolled out nationally in April 2008. It is a wage supplement paid at £40 a week (£60 in London) for 12 months to eligible lone parents moving in to work. From July 2008 to June 2010, a variant on this, the In Work Retention Pilot (IWRP), was trialled in two Jobcentre Plus districts. The IWRP was intended to test the effectiveness of using In Work Credit payments as an aid to job retention and progression, by changing the payment structure of the credits and offering additional advisory support on retention and advancement. This report presents findings from a qualitative evaluation of the IWRP, examining the delivery of the pilot and the views of lone parents and Jobcentre Plus staff on: the distinctive IWRP payment structure; the retention and progression challenges facing lone parents and the support received; and whether and how the IWRP made a difference to work behaviour and decisions. The study is based on interviews, focus groups and observations with Jobcentre Plus delivery staff and participating lone parents

Low Molecular Weight mRNA Encodes a Protein That Controls Serotonin 5-HT_(1c) and Acetylcholine M_1 Receptor Sensitivity in Xenopus Oocytes

Serotonin 5-HT_(1c) and acetylcholine M_1 receptors activate phosphoinositidase, resulting in an increased formation of IP_3 and 1,2 diacylglycerol. In Xenopus oocytes injected with mRNA encoding either of these receptors, Ca^(2+) released from intracellular stores in response to IP3 then opens Ca^(2+)-gated Cl^-channels. In the present experiments, oocytes expressing a transcript from a cloned mouse serotonin 5-HT_(1c) receptor were exposed to identical 15-s pulses of agonist, administered 2 min apart; the second current response was two to three times that of the first. However, in those oocytes coinjected with the 5-HT_(1c) receptor transcript and a low molecular weight fraction (0.3-1.5 kb) of rat brain mRNA, the second current response was ~50% of the first. Thus, the low molecular weight RNA encodes a protein (or proteins) that causes desensitization. Experiments using fura-2 or a Ca^(2+)-free superfusate indicated that desensitization of the 5-HT_(1c) receptor response does not result from a sustained elevation of intracellular Ca^(2+) level or require the entry of extracellular Ca^(2+). Photolysis of caged IP_3 demonstrated that an increase in IP_3 and a subsequent rise in Ca^(2+) do not produce desensitization of either the IP_3 or 5-HT_(1c) peak current responses. Furthermore, in oocytes coinjected with the low molecular weight RNA and a transcript from the rat M_1 acetylcholine receptor, the M_1 current response was greatly attenuated. Our data suggest that the proteins involved in attenuation of the M_1 current response and desensitization of the 5-HT_(1c) current response may be the same

Scotland, Catalonia and the “right” to self-determination: a comment suggested by Kathryn Crameri’s “Do Catalans Have the Right to Decide?

No abstract available