128 research outputs found
Induced molecular dissociations as a radiation damage descriptor: nanodosimetry
Conferencia invitada; IBER 2015, 6-9th September, Aveiro – Portugal; http://iber2015.web.ua.pt/Traditional dosimetry is based on the proportionality between the energy absorbed by
the medium (absorbed dose) and the induced damage. This assumption applies for
relatively high irradiated volumes and requires some equilibrium conditions.
However, for small volumes being relatively far from the central irradiated areas
these conditions are not observed and radiation damage is mainly driven by low
energy secondary species (electrons and radicals) which induce molecular
dissociations via electronic and vibrational excitations, electron attachment and
chemical reactions. We will present here an integrated modelling procedure to
simulate particle radiation tracks including those of all generated secondary species
and their further interactions with the molecular constituent of the medium. For any
selected volume of interest, this model provides not only the total energy transferred
to that area but also the number and type of interactions taking place in it [1].Peer Reviewe
Comparative Evaluation of Action Recognition Methods via Riemannian Manifolds, Fisher Vectors and GMMs: Ideal and Challenging Conditions
We present a comparative evaluation of various techniques for action
recognition while keeping as many variables as possible controlled. We employ
two categories of Riemannian manifolds: symmetric positive definite matrices
and linear subspaces. For both categories we use their corresponding nearest
neighbour classifiers, kernels, and recent kernelised sparse representations.
We compare against traditional action recognition techniques based on Gaussian
mixture models and Fisher vectors (FVs). We evaluate these action recognition
techniques under ideal conditions, as well as their sensitivity in more
challenging conditions (variations in scale and translation). Despite recent
advancements for handling manifolds, manifold based techniques obtain the
lowest performance and their kernel representations are more unstable in the
presence of challenging conditions. The FV approach obtains the highest
accuracy under ideal conditions. Moreover, FV best deals with moderate scale
and translation changes
Modelling secondary particle tracks generated by high-energy protons in water
1 pág.; XXIX International Conference on Photonic, Electronic, and Atomic Collisions (ICPEAC2015); Open Access funded by Creative Commons Atribution Licence 3.0We present interaction probability data of low-energy secondary electrons and positrons produced due to the proton impact. The probability distribution functions serve as input data for the Low Energy Particle Track Simulation (LEPTS) approach which allows one to include the effect of low-energy species in medical applications of radiation and in ion-beam cancer therapy, in particular.This work has been supported by the Spanish Ministry of EconomĂa y Productividad (Project FIS2012-31320). We
also acknowledge partial funding from the
Portuguese Foundation for Science and Technology
(FCT-MCTES), research grant PEstOE/FIS/UI0068/2011,the
EU/ESF COST Actions Nano-IBCT - MP1002 and CELINA CM-
1301, and from the FP7 Multi-ITN Project ”Advanced
Radiotherapy, Generated by Exploiting Nanoprocesses and Technologies” (ARGENT) (Grant Agreement n◦608163).Peer Reviewe
Modeling secondary particle tracks generated by high-energy protons in water
ICPEAC 2015, Toledo, Spain on 22 –28 July 2015; http://www.icpeac2015.com/We present interaction probability data of low-energy secondary electrons and positrons produced due
to the proton impact. The probability distribution functions serve as input data for the Low Energy Particle Track
Simulation (LEPTS) approach which allows one to include the effect of low-energy species in medical applications
of radiation and in ion-beam cancer therapy, in particular.his work has been supported by the Spanish Ministry of EconomĂa
y Productividad (Project FIS2012-31320). We
also acknowledge partial funding from the
Portuguese Foundation for Science and Technology
(FCT-MCTES), research grant PEstOE/FIS/UI0068/2011,the
EU/ESF COST Actions
Nano-IBCT - MP1002 and CELINA CM-
1301, and from the FP7 Multi-ITN Project ”Advanced
Radiotherapy, Generated by Exploiting
Nanoprocesses and Technologies” (ARGENT)
(Grant Agreement nâ—¦608163).Peer Reviewe
Artemisinin-based combinations versus amodiaquine plus sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Faladje, Mali
<p>Abstract</p> <p>Background</p> <p>Because of the emergence of chloroquine resistance in Mali, artemether-lumefantrine (AL) or artesunate-amodiaquine (AS+AQ) are recommended as first-line therapy for uncomplicated malaria, but have not been available in Mali until recently because of high costs.</p> <p>Methods</p> <p>From July 2005 to January 2006, a randomized open-label trial of three oral antimalarial combinations, namely AS+AQ, artesunate plus sulphadoxine-pyrimethamine (AS+SP), and amodiaquine plus sulphadoxine-pyrimethamine (AQ+SP), was conducted in Faladje, Mali. Parasite genotyping by polymerase chain reaction (PCR) was used to distinguish new from recrudescent <it>Plasmodium falciparum </it>infections.</p> <p>Results</p> <p>397 children 6 to 59 months of age with uncomplicated <it>Plasmodium falciparum </it>malaria were enrolled, and followed for 28 days to assess treatment efficacy. Baseline characteristics were similar in all three treatment groups. The uncorrected rates of adequate clinical and parasitologic response (ACPR) were 55.7%, 90.8%, and 97.7% in AS+AQ, AS+SP, and AQ+SP respectively (p < 0.001); after PCR correction ACPR rates were similar among treatment groups: 95.4%, 96.9%, and 99.2% respectively (p = 0.17). Mean haemoglobin concentration increased across all treatment groups from Day 0 (9.82 ± 1.68 g/dL) to Day 28 (10.78 ± 1.49 g/dL) (p < 0.001), with the greatest improvement occurring in children treated with AQ+SP. On Day 2, the prevalence of parasitaemia was significantly greater among children treated with AQ+SP (50.8%) than in children treated with AS+AQ (10.5%) or AS+SP (10.8%) (p < 0.001). No significant difference in gametocyte carriage was found between groups during the follow-up period.</p> <p>Conclusion</p> <p>The combination of AQ+SP provides a potentially low cost alternative for treatment of uncomplicated <it>P. falciparum </it>infection in Mali and appears to have the added value of longer protective effect against new infection.</p
Historical Contingencies Modulate the Adaptability of Rice Yellow Mottle Virus
The rymv1-2 and rymv1-3 alleles of the RYMV1 resistance to Rice yellow mottle virus (RYMV), coded by an eIF(iso)4G1 gene, occur in a few cultivars of the Asiatic (Oryza sativa) and African (O. glaberrima) rice species, respectively. The most salient feature of the resistance breaking (RB) process is the converse genetic barrier to rymv1-2 and rymv1-3 resistance breakdown. This specificity is modulated by the amino acid (glutamic acid vs. threonine) at codon 49 of the Viral Protein genome-linked (VPg), a position which is adjacent to the virulence codons 48 and 52. Isolates with a glutamic acid (E) do not overcome rymv1-3 whereas those with a threonine (T) rarely overcome rymv1-2. We found that isolates with T49 had a strong selective advantage over isolates with E49 in O. glaberrima susceptible cultivars. This explains the fixation of the mutation T49 during RYMV evolution and accounts for the diversifying selection estimated at codon 49. Better adapted to O. glaberrima, isolates with T49 are also more prone than isolates with E49 to fix rymv1-3 RB mutations at codon 52 in resistant O. glaberrima cultivars. However, subsequent genetic constraints impaired the ability of isolates with T49 to fix rymv1-2 RB mutations at codons 48 and 52 in resistant O. sativa cultivars. The origin and role of the amino acid at codon 49 of the VPg exemplifies the importance of historical contingencies in the ability of RYMV to overcome RYMV1 resistance
Sulfate Activation in Mitosomes Plays an Important Role in the Proliferation of Entamoeba histolytica
Mitochondrion-related organelles, mitosomes and hydrogenosomes, are found in a phylogenetically broad range of organisms. Their components and functions are highly diverse. We have previously shown that mitosomes of the anaerobic/microaerophilic intestinal protozoan parasite Entamoeba histolytica have uniquely evolved and compartmentalized a sulfate activation pathway. Although this confined metabolic pathway is the major function in E. histolytica mitosomes, their physiological role remains unknown. In this study, we examined the phenotypes of the parasites in which genes involved in the mitosome functions were suppressed by gene silencing, and showed that sulfate activation in mitosomes is important for sulfolipid synthesis and cell proliferation. We also demonstrated that both Cpn60 and unusual mitochondrial ADP/ATP transporter (mitochondria carrier family, MCF) are important for the mitosome functions. Immunoelectron microscopy demonstrated that the enzymes involved in sulfate activation, Cpn60, and mitochondrial carrier family were differentially distributed within the electron dense, double membrane-bounded organelles. The importance and topology of the components in E. histolytica mitosomes reinforce the notion that they are not “rudimentary” or “residual” mitochondria, but represent a uniquely evolved crucial organelle in E. histolytica
Immunogenicity of Fractional Doses of Tetravalent A/C/Y/W135 Meningococcal Polysaccharide Vaccine: Results from a Randomized Non-Inferiority Controlled Trial in Uganda
Meningitis are infections of the lining of the brain and spinal cord and can cause high fever, blood poisoning, and brain damage, as well as result in death in up to 10% of cases. Epidemics of meningitis occur almost every year in parts of sub-Saharan Africa, throughout a high-burden area spanning Senegal to Ethiopia dubbed the “Meningitis Belt.” Most epidemics in Africa are caused by Neisseria meningitidis (mostly serogroup A and W135). Mass vaccination campaigns attempt to control epidemics by administering meningococcal vaccines targeted against these serogroups, among others. However, global shortages of these vaccines are currently seen. We studied the use of fractional (1/5 and 1/10) doses of a licensed vaccine to assess its non-inferiority compared with the normal full dose. In a randomized trial in Uganda, we found that immune response and safety using a 1/5 dose were comparable to full dose for three serogroups (A, Y, W135), though not a fourth (C). In light of current shortages of meningococcal vaccines and their importance in fighting meningitis epidemics around the world, we suggest fractional doses be taken under consideration in mass vaccination campaigns
Diagnostique visuel des carences nutritionnelles du cotonnier.
bitstream/item/99846/1/COTON-4-ECHANGE-EXPERIENCE-Diagnostique-visuel.pd
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