Effect of barrel-to-barrel variation on color and phenolic composition of a red wine

Tangible variation of sensory characteristics is often observed in wine aged in similar barrels. Barrel-to-barrel variation in barrel-aged wines was investigated in respect of the most important phenolic compounds of oenological interest. A red wine was aged in 49 medium-toasted oak (Quercus petraea) barrels, from four cooperages, for 12 months. The resulting wines were evaluated for chromatic characteristics, anthocyanin-related parameters, total phenols, flavonoids and nonflavonoids phenols, flavanol monomers, and oligomeric and polymeric proanthocyanidins. PCA and ANOVA were applied to investigate the relationships between barrels and to assess cooperage and individual barrel effect. Three cooperages influenced the wine similarly during aging. Anthocyaninrelated parameters showed the highest variation, 25–37%, other phenolics varied 3–8.5%, and with two exceptions, chromatic characteristics changed 1.7–3%. The relationship between the number of barrels and the expected variation for each analytical parameter was calculated, as reference for future measurements involving barrel lots, either in wine production or experimental designinfo:eu-repo/semantics/publishedVersio

Molecular Aspects of Breast Cancer Metastasis to the Brain

Our knowledge of the biology underlying the development of brain metastases (BM) from breast cancer has improved over the last decade due to large clinical epidemiological studies, animal models of metastasis, and the use of high-resolution gene expression profiling technologies. However, there are still major gaps in our understanding of the mechanisms utilized by breast cancer cells to colonize the brain microenvironment, thus our arsenal of therapies remains relatively nonspecific, and the prognosis for breast cancer patients with BM remains poor. Additional insights into these mechanisms are necessary to facilitate the development of new preventive and curative therapeutic regimens to block this fatal disease. This paper aims to provide a general overview for the readers of what has been achieved in this field of research and its translation into clinical practice to date and to highlight exciting new areas of research that promise to inform the development of new targeted therapies for BM

Differential Geometry applied to Acoustics : Non Linear Propagation in Reissner Beams

Although acoustics is one of the disciplines of mechanics, its "geometrization" is still limited to a few areas. As shown in the work on nonlinear propagation in Reissner beams, it seems that an interpretation of the theories of acoustics through the concepts of differential geometry can help to address the non-linear phenomena in their intrinsic qualities. This results in a field of research aimed at establishing and solving dynamic models purged of any artificial nonlinearity by taking advantage of symmetry properties underlying the use of Lie groups. The geometric constructions needed for reduction are presented in the context of the "covariant" approach.Comment: Submitted to GSI2013 - Geometric Science of Informatio

UniXGen: A Unified Vision-Language Model for Multi-View Chest X-ray Generation and Report Generation

Generated synthetic data in medical research can substitute privacy and security-sensitive data with a large-scale curated dataset, reducing data collection and annotation costs. As part of this effort, we propose UniXGen, a unified chest X-ray and report generation model, with the following contributions. First, we design a unified model for bidirectional chest X-ray and report generation by adopting a vector quantization method to discretize chest X-rays into discrete visual tokens and formulating both tasks as sequence generation tasks. Second, we introduce several special tokens to generate chest X-rays with specific views that can be useful when the desired views are unavailable. Furthermore, UniXGen can flexibly take various inputs from single to multiple views to take advantage of the additional findings available in other X-ray views. We adopt an efficient transformer for computational and memory efficiency to handle the long-range input sequence of multi-view chest X-rays with high resolution and long paragraph reports. In extensive experiments, we show that our unified model has a synergistic effect on both generation tasks, as opposed to training only the task-specific models. We also find that view-specific special tokens can distinguish between different views and properly generate specific views even if they do not exist in the dataset, and utilizing multi-view chest X-rays can faithfully capture the abnormal findings in the additional X-rays. The source code is publicly available at: https://github.com/ttumyche/UniXGen

IMPLANTAÇÃO DE MARCOS GEODÉSICOS PARA PROJETOS DE CONSTRUÇÃO E RESTAURAÇÃO DE RODOVIAS

Para que uma rodovia ou qualquer outra aplicação em engenharia seja implementada, existe a necessidade de estabelecer um sistema de referência geodésico. Para estudo de caso, foram implantados marcos geodésicos com a função básica de referenciar um projeto de readequação da rodovia SC-438 entre os municípios de Painel e São Joaquim, no Estado de Santa Catarina. A implantação dos vértices deu-se por meio de rastreio dos sinais dos sistemas constituintes do GNSS (Global Navigation Satellite System), com origem das coordenadas no vértice SAT94025, pertencente à rede brasileira de monitoramento contínuo do GNSS e mantido pelo IBGE (Instituto Brasileiro de Geografia e Estatística). O sistema de projeção cartográfica utilizado para projetos de implantação rodoviária foi o sistema local transverso de mercator (LTM), que possui distorção linear menor que o sistema universal transverso de mercator (UTM), sendo mais adequado para a posterior locação da obra utilizando-se métodos clássicos. A altimetria apoiou-se nas referências de nível da rede de nivelamento geométrico de alta precisão do sistema geodésico brasileiro, cujo um dos circuitos passou pelo local de estudos. Foram estabelecidos, no trecho, 78 vértices para apoio a levantamentos topográficos e métodos mais modernos de levantamento como o RTK (Real Time Kinematic)

INFLUÊNCIA DA ALTITUDE NA DEFORMAÇÃO DE ÁREAS PROJETADAS NOS SISTEMAS PLANOS UTM, LTM E RTM

Atualmente, o sistema de projeção cartográfica mais utilizado é o UTM, por propor o uso de fórmulas simplificadas para cálculo que podem ser usadas facilmente em campo além de proporcionar precisões suficientes para a maioria dos trabalhos, com ressalvas quanto à utilização em obras de engenharia. Para obras que necessitem de uma melhor precisão para locação, eliminando as distorções inerentes a transformação de elementos sobre a superfície elipsóidica para a superfície plana, a melhor opção é a conversão das coordenadas planas UTM em coordenadas plano topográficas locais (levando em consideração a altitude), sendo admitidos em alguns tipos de serviços também os sistemas de projeção LTM e RTM. Na comparação feita, ao nível do mar a área que mais se aproximou do valor calculado para plano Topográfico Local foi o sistema LTM seguido pelo RTM e a maior diferença para o UTM. A comparação feita em altitude a que mais se aproximou da área computada do plano Topográfico Local foi a RTM, seguido pela LTM e a maior diferença permaneceu sendo a UTM. Analisando-se as diferenças relativas observou-se que houve uma ligeira piora nos resultados levando-se em consideração a altitude.Palavras-chave: Topografia. Geodésia. Cartografia. Sistemas de Projeção

A cross-sectional survey on respiratory disease in a cohort of Irish pig farms

Altres ajuts: Department of Agriculture, Food and the Marine PathSurvPig 14/S/832Respiratory disease is one of the most important factors impacting pig production worldwide. There is no available information on the prevalence of key pathogens implicated in Irish pig production. The objective of this study was to describe the prevalence of pleurisy, pneumonia, lung abscesses, pericarditis and liver milk spots in finisher pigs of a cohort of Irish pig farms, and to describe the seroprevalence of: influenza A virus (IAV), porcine reproductive and respiratory syndrome virus (PRRSv), Mycoplasma hyopneumoniae (Mhyo) and Actinobacillus pleuropneumoniae (APP). In brief, 56 farrow-to-finish farms (29% of the Irish breeding herd) were enrolled in the study in 2017. Data on lungs, heart, and liver lesions were assessed for each farm at slaughter. An average of 417 (range 129-1154) plucks per farm were assessed for pleurisy, pneumonia, lung abscesses, pericarditis, and liver milk spots. Blood samples from 32 finisher pigs were collected at slaughter for each farm. The observed prevalence of pleurisy and pneumonia was one of the lowest reported in similar studies in Europe (13 and 11% estimated average within farm, respectively). Pleurisy lesions were mostly moderate and severe. Pneumonia lesions affected a low level of lung surface (5.8%). Prevalence of pericarditis was mid-high (8%) and the prevalence of liver milk spots was high, with an average of 29% of the livers affected. For serology, 78.6% of the farms were positive for IAV, 50% were positive for PRRSv, 71.4% were positive for Mhyo, and 98.2% were positive for APP. Influenza virus was the main pathogen associated with pleurisy (P < 0.001) and Mhyo was the main pathogen associated with pneumonia (P < 0.001) and pericarditis (P = 0.024). Farms affected with pleurisy had moderate to severe lesions. Farms affected with pneumonia had mild lesions, which could be the effect of the generalised use of Mhyo vaccination in piglets. The seroprevalence of IAV, PRRSv, Mhyo and APP in the present study sample is similar to or lower than in other European countries. Further research on the PRRSv and APP strains circulating in Ireland is necessary to support the design of national or regional control plans

The influence of stellar-dynamical ejections and collisions on the relation between the maximum-star and star-cluster-mass

We perform the largest currently available set of direct N-body calculations of young star cluster models to study the dynamical influence, especially through the ejections of the most massive star in the cluster, on the current relation between the maximum-stellar-mass and the star-cluster-mass. We vary several initial parameters such as the initial half-mass radius of the cluster, the initial binary fraction, and the degree of initial mass segregation. Two different pairing methods are used to construct massive binaries for more realistic initial conditions of massive binaries. We find that lower mass clusters (<= 10^2.5 Msun) do not shoot out their heaviest star. In the case of massive clusters (>= 1000 Msun), no most-massive star escapes the cluster within 3 Myr regardless of the initial conditions if clusters have initial half-mass radii, r_0.5, >= 0.8 pc. However, a few of the initially smaller sized clusters (r_0.5 = 0.3 pc), which have a higher density, eject their most massive star within 3 Myr. If clusters form with a compact size and their massive stars are born in a binary system with a mass-ratio biased towards unity, the probability that the mass of the most massive star in the cluster changes due to the ejection of the initially most massive star can be as large as 20 per cent. Stellar collisions increase the maximum-stellar-mass in a large number of clusters when clusters are relatively dense (M_ecl >= 10^3 Msun and r_0.5 = 0.3 pc) and binary-rich. Overall, we conclude that dynamical effects hardly influence the observational maximum-stellar-mass -- cluster mass relation.Comment: 16 pages, 8 figures, 5 tables, accepted for publication in MNRA