551 research outputs found
The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000-2015).
BACKGROUND: Seronegative villous atrophy (SNVA) is commonly attributed to coeliac disease (CD). However, there are other causes of SNVA. More recently angiotensin-2-receptor-blockers (A2RBs) have been reported as an association but data on SNVA have been limited to centres evaluating complex case referrals and not SNVA in general. OBJECTIVES: To provide clinical outcomes and associations in a large prospective study overseeing all newcomers with SNVA. DESIGN: Over a 15-year period (2000-2015) we evaluated 200 adult patients with SNVA at a UK centre. A diagnosis of either seronegative CD (SNCD) or seronegative non-CD (SN-non-CD) was reached. Baseline comparisons were made between the groups, with 343 seropositive CD subjects serving as controls. RESULTS: Of the 200 SNVA cases, SNCD represented 31% (n=62) and SN-non-CD 69% (n=138). The human leucocyte antigen (HLA)-DQ2 and/or DQ8 genotype was present in 61%, with a 51% positive predictive value for SNCD. The breakdown of identifiable causes in the SN-non-CD group comprised infections (27%, n=54), inflammatory/immune-mediated disorders (17.5%, n=35) and drugs (6.5%, n=13; two cases related to A2RBs). However, no cause was found in 18% (n=36) and of these 72% (n=26/36) spontaneously normalised duodenal histology while consuming a gluten-enriched diet. Following multivariable logistic regression analysis an independent factor associated with SN-non-CD was non-white ethnicity (OR 10.8, 95% CI 2.2 to 52.8); in fact, 66% of non-whites had GI infections. On immunohistochemistry all groups stained positive for CD8-T-cytotoxic intraepithelial lymphocytes. However, additional CD4-T helper intraepithelial lymphocytes were occasionally seen in SN-non-CD mimicking the changes associated with refractory CD. CONCLUSIONS: Most patients with SNVA do not have CD, in particular those who are not white. Furthermore, a subgroup with no obvious aetiology will show spontaneous histological resolution while consuming gluten. These findings suggest caution in empirically prescribing a gluten-free diet without investigation
Dark mammoth trunks in the merging galaxy NGC 1316 and a mechanism of cosmic double helices
NGC 1316 is a giant, elliptical galaxy containing a complex network of dark,
dust features. The morphology of these features has been examined in some
detail using a Hubble Space Telescope, Advanced Camera for Surveys image. It is
found that most of the features are constituted of long filaments. There also
exist a great number of dark structures protruding inwards from the filaments.
Many of these structures are strikingly similar to elephant trunks in H II
regions in the Milky Way Galaxy, although much larger. The structures, termed
mammoth trunks, generally are filamentary and often have shapes resembling the
letters V or Y. In some of the mammoth trunks the stem of the Y can be resolved
into two or more filaments, many of which showing signs of being intertwined. A
model of the mammoth trunks, related to a recent theory of elephant trunks, is
proposed. Based on magnetized filaments, the model is capable of giving an
account of the various shapes of the mammoth trunks observed, including the
twined structures.Comment: Accepted for publication in Astrophysics & Space Scienc
Confirmation of a pi_1^0 Exotic Meson in the \eta \pi^0 System
The exclusive reaction , at 18 GeV has been studied with a partial wave analysis on a sample
of 23~492 events from BNL experiment E852. A mass-dependent fit
is consistent with a resonant hypothesis for the wave, thus providing
evidence for a neutral exotic meson with , a mass of MeV, and a width of MeV. New
interpretations of the meson exotics in neutral system observed in
E852 and Crystal Barrel experiments are discussed.Comment: p3, rewording the paragraph (at the bottom) about the phase
variations. p4, rewording paragrath "The second method ..." . p4, at the
bottom of paragrath "The third method ..." added consistent with the results
of methods 1 and 2
Finite size and temperature effects in the AF Heisenberg model
The low temperature and large volume effects in the d=2+1 antiferromagnetic
quantum Heisenberg model are dominated by magnon excitations. The leading and
next-to-leading corrections are fully controlled by three physical constants,
the spin stiffness, the spin wave velocity and the staggered magnetization.
Among others, the free energy, the ground state energy, the low lying
excitations, staggered magnetization, staggered and uniform susceptibilities
are studied here. The special limits of very low temperature and infinite
volume are considered also.Comment: 44 pages, LATEX, no figure
Environmental metabarcoding reveals heterogeneous drivers of microbial eukaryote diversity in contrasting estuarine ecosystems
Assessing how natural environmental drivers affect biodiversity underpins our understanding of the relationships between complex biotic and ecological factors in natural ecosystems. Of all ecosystems, anthropogenically important estuaries represent a �melting pot� of environmental stressors, typified by extreme salinity variations and associated biological complexity. Although existing models attempt to predict macroorganismal diversity over estuarine salinity gradients, attempts to model microbial biodiversity are limited for eukaryotes. Although diatoms commonly feature as bioindicator species, additional microbial eukaryotes represent a huge resource for assessing ecosystem health. Of these, meiofaunal communities may represent the optimal compromise between functional diversity that can be assessed using morphology and phenotype�environment interactions as compared with smaller life fractions. Here, using 454 Roche sequencing of the 18S nSSU barcode we investigate which of the local natural drivers are most strongly associated with microbial metazoan and sampled protist diversity across the full salinity gradient of the estuarine ecosystem. In order to investigate potential variation at the ecosystem scale, we compare two geographically proximate estuaries (Thames and Mersey, UK) with contrasting histories of anthropogenic stress. The data show that although community turnover is likely to be predictable, taxa are likely to respond to different environmental drivers and, in particular, hydrodynamics, salinity range and granulometry, according to varied life-history characteristics. At the ecosystem level, communities exhibited patterns of estuary-specific similarity within different salinity range habitats, highlighting the environmental sequencing biomonitoring potential of meiofauna, dispersal effects or both
Decoherence and Programmable Quantum Computation
An examination of the concept of using classical degrees of freedom to drive
the evolution of quantum computers is given. Specifically, when externally
generated, coherent states of the electromagnetic field are used to drive
transitions within the qubit system, a decoherence results due to the back
reaction from the qubits onto the quantum field. We derive an expression for
the decoherence rate for two cases, that of the single-qubit Walsh-Hadamard
transform, and for an implementation of the controlled-NOT gate. We examine the
impact of this decoherence mechanism on Grover's search algorithm, and on the
proposals for use of error-correcting codes in quantum computation.Comment: submitted to Phys. Rev. A 35 double-spaced pages, 2 figures, in LaTe
Exotic Meson Production in the System observed in the Reaction at 18 GeV/c
This letter reports results from the partial wave analysis of the
final state in collisions at 18GeV/c.
Strong evidence is observed for production of two mesons with exotic quantum
numbers of spin, parity and charge conjugation, in the decay
channel . The mass MeV/c^2 and
width MeV/c^2 of the first state are consistent
with the parameters of the previously observed . The second
resonance with mass MeV/c^2 and width MeV/c^2 agrees very well with predictions from theoretical
models. In addition, the presence of is confirmed with mass MeV/c^2 and width MeV/c^2
and a new state, , is observed with mass
MeV/c^2 and width MeV/c^2. The decay properties of
these last two states are consistent with flux tube model predictions for
hybrid mesons with non-exotic quantum numbers
The effect of biomass ashes and potassium salts on MEA degradation for BECCS
This study investigates the comparative impact of inherently different biomass and coal ashes on the laboratory and pilot scale degradation of 30 wt% aqueous monoethanolamine (MEA), relevant to post-combustion CO2 capture. Thermal and oxidative degradation experiments were carried out at 135 °C and 40 °C respectively with CO2 loading (0.5 molCO2/molMEA), with and without the presence of ash. Nuclear magnetic resonance (NMR) data is provided for the major MEA degradation compounds such as N-(2-hydroxyethyl)formamide (HEF) and N-(2-hydroxyethyl)imidazole (HEI) along with the characterisation of a new MEA oxidative degradation product, N-(2-hydroxyethyl)imidazole-N-oxide (HEINO) which had been previously misassigned. Degradation products were quantified using 1H NMR and gas chromatography mass spectrometry (GC–MS) to assess the impact of potassium and various ashes from combustion (olive, white wood and two types of coal ash) on the rates of amine degradation. Woody biomass fly ashes were found to reduce the presence of the oxidative degradation products. Both types of coal fly ash and the olive biomass ash were found to enhance the formation the newly identified degradation product, HEINO. Solvent samples taken from a pilot scale facility support these laboratory findings
Finite one dimensional impenetrable Bose systems: Occupation numbers
Bosons in the form of ultra cold alkali atoms can be confined to a one
dimensional (1d) domain by the use of harmonic traps. This motivates the study
of the ground state occupations of effective single particle states
, in the theoretical 1d impenetrable Bose gas. Both the system on a
circle and the harmonically trapped system are considered. The and
are the eigenvalues and eigenfunctions respectively of the one body
density matrix. We present a detailed numerical and analytic study of this
problem. Our main results are the explicit scaled forms of the density
matrices, from which it is deduced that for fixed the occupations
are asymptotically proportional to in both the circular
and harmonically trapped cases.Comment: 22 pages, 8 figures (.eps), uses REVTeX
Low energy and dynamical properties of a single hole in the t-Jz model
We review in details a recently proposed technique to extract information
about dynamical correlation functions of many-body hamiltonians with a few
Lanczos iterations and without the limitation of finite size. We apply this
technique to understand the low energy properties and the dynamical spectral
weight of a simple model describing the motion of a single hole in a quantum
antiferromagnet: the model in two spatial dimension and for a double
chain lattice. The simplicity of the model allows us a well controlled
numerical solution, especially for the two chain case. Contrary to previous
approximations we have found that the single hole ground state in the infinite
system is continuously connected with the Nagaoka fully polarized state for
. Analogously we have obtained an accurate determination of the
dynamical spectral weight relevant for photoemission experiments. For
an argument is given that the spectral weight vanishes at the Nagaoka energy
faster than any power law, as supported also by a clear numerical evidence. It
is also shown that spin charge decoupling is an exact property for a single
hole in the Bethe lattice but does not apply to the more realistic lattices
where the hole can describe closed loop paths.Comment: RevTex 3.0, 40 pages + 16 Figures in one file self-extracting, to
appear in Phys. Rev
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