The Epitheliome: agent-based modelling of the social behaviour of cells

We have developed a new computational modelling paradigm for predicting the emergent behaviour resulting from the interaction of cells in epithelial tissue. As proof-of-concept, an agent-based model, in which there is a one-to-one correspondence between biological cells and software agents, has been coupled to a simple physical model. Behaviour of the computational model is compared with the growth characteristics of epithelial cells in monolayer culture, using growth media with low and physiological calcium concentrations. Results show a qualitative fit between the growth characteristics produced by the simulation and the in vitro cell models

Experimental determination of the dispersion relation of magnetosonic waves

Magnetosonic waves are commonly observed in the vicinity of the terrestrial magnetic equator. It has been proposed that within this region they may interact with radiation belt electrons, accelerating some to high energies. These wave-particle interactions depend upon the characteristic properties of the wave mode. Hence, determination of the wave properties is a fundamental part of understanding these interaction processes. Using data collected during the Cluster Inner Magnetosphere Campaign, this paper identifies an occurrence of magnetosonic waves, discusses their generation and propagation properties from a theoretical perspective, and utilizes multispacecraft measurements to experimentally determine their dispersion relation. Their experimental dispersion is found to be in accordance with that based on cold plasma theory

Connecting ‘Human’ and ‘Social’ Discourses: The Human Development, Human Security, and Social Quality Approaches

__Abstract__ The human development approach emerged in the late 1980s in response to the negative effects of structural adjustment programmes applied to countries in the South. Led originally by two South Asian scholars, Mahbub ul Haq and Amartya Sen, in cooperation with a large international network, the approach is comparative in perspective and global in reach and has been incorporated into parts of the United Nations (UN) system, including the United Nations Development Programme. Over the years this approach has integrated three dimensions – human development, human rights and human security –, and looks at people’s well-being or ill-being, security and insecurity, in the context of issues arising from global interconnectedness and inequities. It has had significant influence, but one constraint has been that its focus on the ‘human’ is accompanied by a widely recognised gap in respect of ‘the social’ (Apthorpe 1997, Gasper 2011, Phillips 2011)

Tracing Nitrogen in Volcanic and Geothermal Volatiles from the Nicaraguan Volcanic Front

We report new chemical and isotopic data from 26 volcanic and geothermal gases, vapor condensates, and thermal water samples, collected along the Nicaraguan volcanic front. The samples were analyzed for chemical abundances and stable isotope compositions, with a focus on nitrogen abundances and isotope ratios. These data are used to evaluate samples for volatile contributions from magma, air, air-saturated water, and the crust. Samples devoid of crustal contamination (based upon He isotope composition) but slightly contaminated by air or air-saturated water are corrected using N2/Ar ratios in order to obtain primary magmatic values, composed of contributions from upper mantle and subducted hemipelagic sediment on the down-going plate. Using a mantle endmember with d15N= 5&and N2/He = 100 and a subducted sediment component with d15N=+7& and N2/He = 10,500, the average sediment contribution to Nicaraguan volcanic and geothermal gases was determined to be 71%. Most of the gases were dominated by sediment-derived nitrogen, but gas from Volca´n Mombacho, the southernmost sampling location, had a mantle signature (46% from subducted sediment, or 54% from the mantle) and an affinity with mantle-dominated gases discharging from Costa Rica localities to the south. High CO2/N2 exc. ratios (N2 exc. is the N2 abundance corrected for contributions from air) in the south are similar to those in Costa Rica, and reflect the predominant mantle wedge input, whereas low ratios in the north indicate contribution by altered oceanic crust and/or preferential release of nitrogen over carbon from the subducting slab. Sediment-derived nitrogen fluxes at the Nicaraguan volcanic front, estimated by three methods, are 7.8 · 108 mol N/a from 3He flux, 6.9 · 108 mol/a from SO2 flux, and 2.1 · 108 and 1.3 · 109 mol/a from CO2 fluxes calculated from 3He and SO2, respectively. These flux results are higher than previous estimates for Central America, reflecting the high sediment-derived volatile contribution and the high nitrogen content of geothermal and volcanic gases in Nicaragua. The fluxes are also similar to but higher than estimated hemipelagic nitrogen inputs at the trench, suggesting addition of N from altered oceanic basement is needed to satisfy these flux estimates. The similarity of the calculated input of N via the trench to our calculated outputs suggests that little or none of the subducted nitrogen is being recycled into the deeper mantle, and that it is, instead, returned to the surface via arc volcanism

Human security and social quality: contrasts and complementaries

Two authors who have been leaders of the "social quality approach" that emerged in European social policy circles in the 1990s, and two authors who have worked with the "human development" and "human security" approaches that emerged in international development policy circles in the 1980s and 90s, collaborate in this paper in order to outline and compare the two traditions. The "human development" tradition has focused on the quality of individual human lives, understood as influenced by interconnections that transcend conventional disciplinary boundaries; its "human security" branch goes deeper into study of human vulnerability and the textures of daily life. The "social quality" tradition tries to understand individual lives as lived within a societal fabric, to identify and measure key elements of that fabric, and to develop a correspondingly grounded public policy approach. The paper is a first step in a project to assess the possible complementarity, in theorising and practical application, of these two streams of work

Statistics of Coulomb blockade peak spacings for a partially open dot

We show that randomness of the electron wave functions in a quantum dot contributes to the fluctuations of the positions of the conductance peaks. This contribution grows with the conductance of the junctions connecting the dot to the leads. It becomes comparable with the fluctuations coming from the randomness of the single particle spectrum in the dot while the Coulomb blockade peaks are still well-defined. In addition, the fluctuations of the peak spacings are correlated with the fluctuations of the conductance peak heights.Comment: 13 pages, 1 figur

The Large Magellanic Cloud and the Distance Scale

The Magellanic Clouds, especially the Large Magellanic Cloud, are places where multiple distance indicators can be compared with each other in a straight-forward manner at considerable precision. We here review the distances derived from Cepheids, Red Variables, RR Lyraes, Red Clump Stars and Eclipsing Binaries, and show that the results from these distance indicators generally agree to within their errors, and the distance modulus to the Large Magellanic Cloud appears to be defined to 3% with a mean value of 18.48 mag, corresponding to 49.7 Kpc. The utility of the Magellanic Clouds in constructing and testing the distance scale will remain as we move into the era of Gaia.Comment: 23 pages, accepted for publication in Astrophysics and Space Science. From a presentation at the conference The Fundamental Cosmic Distance Scale: State of the Art and the Gaia Perspective, Naples, May 201

Can forest management based on natural disturbances maintain ecological resilience?

Given the increasingly global stresses on forests, many ecologists argue that managers must maintain ecological resilience: the capacity of ecosystems to absorb disturbances without undergoing fundamental change. In this review we ask: Can the emerging paradigm of natural-disturbance-based management (NDBM) maintain ecological resilience in managed forests? Applying resilience theory requires careful articulation of the ecosystem state under consideration, the disturbances and stresses that affect the persistence of possible alternative states, and the spatial and temporal scales of management relevance. Implementing NDBM while maintaining resilience means recognizing that (i) biodiversity is important for long-term ecosystem persistence, (ii) natural disturbances play a critical role as a generator of structural and compositional heterogeneity at multiple scales, and (iii) traditional management tends to produce forests more homogeneous than those disturbed naturally and increases the likelihood of unexpected catastrophic change by constraining variation of key environmental processes. NDBM may maintain resilience if silvicultural strategies retain the structures and processes that perpetuate desired states while reducing those that enhance resilience of undesirable states. Such strategies require an understanding of harvesting impacts on slow ecosystem processes, such as seed-bank or nutrient dynamics, which in the long term can lead to ecological surprises by altering the forest's capacity to reorganize after disturbance

Reducing reversal errors in localizing the source of sound in virtual environment without head tracking

International audienceThis paper presents a study about the effect of using additional audio cueing and Head-Related Transfer Function (HRTF) on human performance in sound source localization task without using head movement. The existing techniques of sound spatialization generate reversal errors. We intend to reduce these errors by introducing sensory cues based on sound effects. We conducted and experimental study to evaluate the impact of additional cues in sound source localization task. The results showed the benefit of combining the additional cues and HRTF in terms of the localization accuracy and the reduction of reversal errors. This technique allows significant reduction of reversal errors compared to the use of the HRTF separately. For instance, this technique could be used to improve audio spatial alerting, spatial tracking and target detection in simulation applications when head movement is not included