Wnt signalling and cancer stem cells

[Abstract] Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult tissues. Aberrant activation of Wnt signalling pathways has been directly linked to the genesis of different tumours. Here, the components and molecular mechanisms implicated in the transduction of Wnt signal, along with important results supporting a central role for this signalling pathway in stem cell function regulation and carcinogenesis will be briefly reviewed.Ministerio de Ciencia e Innovación; SAF2008-0060

Sub-critical crack growth and clad integrity in a PWR reactor pressure vessel

SIGLEAvailable from British Library Document Supply Centre- DSC:9091.9F(ND-R--1532(S)) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Effects of cathodic protection potential and stress ratio on fatigue thresholds of structural steels in sea water

Report also known as ND-M--3888(S)Available from British Library Document Supply Centre- DSC:6244.2239(OTO--89-019) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Source-Level Debugging for Multiple Languages with Modest Programming Effort

Abstract. We present techniques that enable source-level debugging for multiple languages at the cost of only modest programming effort. The key idea is to avoid letting debugging requirements constrain the internal structure of the compiler. Constraints are minimized primarily by hiding the source-language type system and target-machine representations from the debugger. This approach enables us to support a new language and compiler while reusing existing elements: a multi-language, multi-platform debugger; the compiler’s implementation of source-language types and expressions; information already present in the compiler’s private data structures; and our compile-time support library, which helps the compiler meet its obligations to the debugger without exposing languagedependent details. We evaluate our approach using two case studies: the production compiler lcc and an instructional compiler for MiniJava.