34 research outputs found
Electron energy loss and induced photon emission in photonic crystals
The interaction of a fast electron with a photonic crystal is investigated by
solving the Maxwell equations exactly for the external field provided by the
electron in the presence of the crystal. The energy loss is obtained from the
retarding force exerted on the electron by the induced electric field. The
features of the energy loss spectra are shown to be related to the photonic
band structure of the crystal. Two different regimes are discussed: for small
lattice constants relative to the wavelength of the associated electron
excitations , an effective medium theory can be used to describe the
material; however, for the photonic band structure plays an
important role. Special attention is paid to the frequency gap regions in the
latter case.Comment: 12 pages, 7 figure
Local and global behaviour of nonlinear equations with natural growth terms
This paper concerns a study of the pointwise behaviour of positive solutions
to certain quasi-linear elliptic equations with natural growth terms, under
minimal regularity assumptions on the underlying coefficients. Our primary
results consist of optimal pointwise estimates for positive solutions of such
equations in terms of two local Wolff's potentials.Comment: In memory of Professor Nigel Kalto
Observing the First Stars and Black Holes
The high sensitivity of JWST will open a new window on the end of the
cosmological dark ages. Small stellar clusters, with a stellar mass of several
10^6 M_sun, and low-mass black holes (BHs), with a mass of several 10^5 M_sun
should be directly detectable out to redshift z=10, and individual supernovae
(SNe) and gamma ray burst (GRB) afterglows are bright enough to be visible
beyond this redshift. Dense primordial gas, in the process of collapsing from
large scales to form protogalaxies, may also be possible to image through
diffuse recombination line emission, possibly even before stars or BHs are
formed. In this article, I discuss the key physical processes that are expected
to have determined the sizes of the first star-clusters and black holes, and
the prospect of studying these objects by direct detections with JWST and with
other instruments. The direct light emitted by the very first stellar clusters
and intermediate-mass black holes at z>10 will likely fall below JWST's
detection threshold. However, JWST could reveal a decline at the faint-end of
the high-redshift luminosity function, and thereby shed light on radiative and
other feedback effects that operate at these early epochs. JWST will also have
the sensitivity to detect individual SNe from beyond z=10. In a dedicated
survey lasting for several weeks, thousands of SNe could be detected at z>6,
with a redshift distribution extending to the formation of the very first stars
at z>15. Using these SNe as tracers may be the only method to map out the
earliest stages of the cosmic star-formation history. Finally, we point out
that studying the earliest objects at high redshift will also offer a new
window on the primordial power spectrum, on 100 times smaller scales than
probed by current large-scale structure data.Comment: Invited contribution to "Astrophysics in the Next Decade: JWST and
Concurrent Facilities", Astrophysics & Space Science Library, Eds. H.
Thronson, A. Tielens, M. Stiavelli, Springer: Dordrecht (2008
Academic language socialisation in high school writing conferences
This study examines multilingual high school writersâ individual talk with their teachers in two advanced English language development classes to observe how such talk shapes linguistically diverse adolescentsâ writing. Addressing adolescent writersâ language socialization through microethnographic discourse analysis, the author argues that teachersâ oral responses during writing conferences can either scaffold or deter studentsâ socialization into valued ways of using academic language for school writing. She suggests what forms of oral response provide scaffolding and what forms might limit multilingual adolescent learnersâ academic literacy. Constructive interactions engaged students in dialogue about their writing, and students included content or phrasing from the interaction in their texts. Unhelpful interactions failed to foster studentsâ language development in observable ways. Although teachers attempted to scaffold ideas and language, they often did not guide studentsâ discovery of appropriate forms or points. These interactions represent restrictive academic language socialization: while some students did create academic texts, they learned little about academic language use
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy1. The study of large patient cohorts incorporating longitudinal plasma sampling and extended follow-up is required to determine the role of ctDNA as a phylogenetic biomarker of relapse in early-stage non-small-cell lung cancer (NSCLC). Here we developed ctDNA methods tracking a median of 200 mutations identified in resected NSCLC tissue across 1,069 plasma samples collected from 197 patients enrolled in the TRACERx study2. A lack of preoperative ctDNA detection distinguished biologically indolent lung adenocarcinoma with good clinical outcome. Postoperative plasma analyses were interpreted within the context of standard-of-care radiological surveillance and administration of cytotoxic adjuvant therapy. Landmark analyses of plasma samples collected within 120 days after surgery revealed ctDNA detection in 25% of patients, including 49% of all patients who experienced clinical relapse; 3 to 6 monthly ctDNA surveillance identified impending disease relapse in an additional 20% of landmark-negative patients. We developed a bioinformatic tool (ECLIPSE) for non-invasive tracking of subclonal architecture at low ctDNA levels. ECLIPSE identified patients with polyclonal metastatic dissemination, which was associated with a poor clinical outcome. By measuring subclone cancer cell fractions in preoperative plasma, we found that subclones seeding future metastases were significantly more expanded compared with non-metastatic subclones. Our findings will support (neo)adjuvant trial advances and provide insights into the process of metastatic dissemination using low-ctDNA-level liquid biopsy
Long-term patterns of hillslope erosion by earthquake-induced landslides shape mountain landscapes
Widespread triggering of landslides by large storms or earthquakes is a dominant mechanism of erosion in mountain landscapes. If landslides occur repeatedly in particular locations within a mountain range, then they will dominate the landscape evolution of that section and could leave a fingerprint in the topography. Here, we track erosion provenance using a novel combination of the isotopic and molecular composition of organic matter deposited in Lake Paringa, New Zealand. We find that the erosion provenance has shifted markedly after four large earthquakes over 1000 years. Postseismic periods eroded organic matter from a median elevation of 722 +329/â293 m and supplied 43% of the sediment in the core, while interseismic periods sourced from lower elevations (459 +256/â226 m). These results are the first demonstration that repeated large earthquakes can consistently focus erosion at high elevations, while interseismic periods appear less effective at modifying the highest parts of the topography