Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

The criminal profiling illusion:what's behind the smoke and mirrors?

There is a belief that criminal profilers can predict a criminal's characteristics from crime scene evidence. In this article, the authors argue that this belief may be an illusion and explain how people may have been misled into believing that criminal profiling (CP) works despite no sound theoretical grounding and no strong empirical support for this possibility. Potentially responsible for this illusory belief is the information that people acquire about CP, which is heavily influenced by anecdotes, repetition of the message that profiling works, the expert profiler label, and a disproportionate emphasis on correct predictions. Also potentially responsible are aspects of information processing such as reasoning errors, creating meaning out of ambiguous information, imitating good ideas, and inferring fact from fiction. The authors conclude that CP should not be used as an investigative tool because it lacks scientific support

Distal and proximal parenting as alternative parenting strategies during infants' early months of life: A cross-cultural study

Keller H, Borke J, Staufenbiel T, et al. Distal and proximal parenting as alternative parenting strategies during infants' early months of life: A cross-cultural study. International Journal of Behavioral Development. 2009;33(5):412-420.Cultures differ with respect to parenting strategies already during infancy. Distal parenting, i.e., face-to-face context and object stimulation, is prevalent in urban educated middle-class families of Western cultures; proximal parenting, i.e., body contact and body stimulation, is prevalent in rural, low-educated farmer families. Parents from urban educated families in cultures with a more interdependent history use both strategies. Besides these cultural preferences, little is known about the relations between these styles as well as the behavioural systems constituting them. In this study therefore, the relations between the styles and the constituting behaviours were analysed in samples that differ with respect to their preferences of distal and proximal parenting. The hypothesized differences between the samples and the negative relationship between distal and proximal parenting, as well as between the respective behavioural systems can clearly be demonstrated. Furthermore, the impact of the sociodemographic variables with respect to the parenting strategies can be shown. Results were discussed as supporting two alternative parenting strategies that serve different socialization goals