Symmetrical Catalytically Active Colloids Collectively Induce Convective Flow

Although much attention has focused on self-motile asymmetrical catalytically active “Janus” colloids as a route to enable new fluidic transport applications, the motion of symmetrical catalytically active colloids is less investigated. This is despite isotropically active colloids being more accessible and commonly used as supports for heterogeneous catalysis. Here, we addressed this by systematically investigating the motion of platinum-coated colloids capable of isotropically decomposing hydrogen peroxide. We observed the onset of collective convective flow as the colloidal volume fraction increased above a threshold. The ballistic velocities induced by the collective flow were quantified by particle tracking and were found to increase with the volume fraction. We also determined the associated increase in the Péclet number as evidence of the potential to use convection as a simple method to enhance mass transport rates. By determining the persistence lengths, we were able to correlate the magnitude of convective flow with the overall catalytic activity per unit volume. This suggests that the mechanism for the collective flow is driven by chemical activity-induced local density differences. Finally, we discussed these results in the context of potential new fluidic applications and highlighted the role that activity-induced convection may play in experiments designed to investigate self-motile catalytic systems

Correction to: “Constraining climate forecasts: The role of prior assumptions”

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Silk fibroin as a functional biomaterial for tissue engineering

Tissue engineering (TE) is the approach to combine cells with scaffold materials and appropriate growth factors to regenerate or replace damaged or degenerated tissue or organs. The scaffold material as a template for tissue formation plays the most important role in TE. Among scaffold materials, silk fibroin (SF), a natural protein with outstanding mechanical properties, biodegradability, biocompatibility, and bioresorbability has attracted significant attention for TE applications. SF is commonly dissolved into an aqueous solution and can be easily reconstructed into different material formats, including films, mats, hydrogels, and sponges via various fabrication techniques. These include spin coating, electrospinning, freeze drying, physical, and chemical crosslinking techniques. Furthermore, to facilitate fabrication of more complex SF-based scaffolds with high precision techniques including micro-patterning and bio-printing have recently been explored. This review introduces the physicochemical and mechanical properties of SF and looks into a range of SF-based scaffolds that have been recently developed. The typical TE applications of SF-based scaffolds including bone, cartilage, ligament, tendon, skin, wound healing, and tympanic membrane, will be highlighted and discussed, followed by future prospects and challenges needing to be addressed

Core Structure of Global Vortices in Brane World Models

We study analytically and numerically the core structure of global vortices forming on topologically deformed brane-worlds with a single toroidally compact extra dimension. It is shown that for an extra dimension size larger than the scale of symmetry breaking the magnitude of the complex scalar field at the vortex center can dynamically remain non-zero. Singlevaluedness and regularity are not violated. Instead, the winding escapes to the extra dimension at the vortex center. As the extra dimension size decreases the field magnitude at the core dynamically decreases also and in the limit of zero extra dimension size we reobtain the familiar global vortex solution. Extensions to other types of defects and gauged symmetries are also discussed.Comment: 6 two column pages, 3 figure

High-energy gamma-ray emission from the inner jet of LS I+61 303: the hadronic contribution revisited

LS I+61 303 has been detected by the Cherenkov telescope MAGIC at very high energies, presenting a variable flux along the orbital motion with a maximum clearly separated from the periastron passage. In the light of the new observational constraints, we revisit the discussion of the production of high-energy gamma rays from particle interactions in the inner jet of this system. The hadronic contribution could represent a major fraction of the TeV emission detected from this source. The spectral energy distribution resulting from p-p interactions is recalculated. Opacity effects introduced by the photon fields of the primary star and the stellar decretion disk are shown to be essential in shaping the high-energy gamma-ray light curve at energies close to 200 GeV. We also present results of Monte Carlo simulations of the electromagnetic cascades developed very close to the periastron passage. We conclude that a hadronic microquasar model for the gamma-ray emission in LS I +61 303 can reproduce the main features of its observed high-energy gamma-ray flux.Comment: 6 pages. Sligth improvements made. Accepted version by Astrophysics and Space Scienc

Patterning the neuronal cells via inkjet printing of self-assembled peptides on silk scaffolds

The patterning of neuronal cells and guiding neurite growth are important for neuron tissue engineering and cell-based biosensors. In this paper, inkjet printing has been employed to pattern self-assembled I3QGK peptide nanofibers on silk substrates for guiding the growth of neuron-like PC12 cells. Atomic force microscopy (AFM) confirmed the dynamic self-assembly of I3QGK into nanofiber structures. The printed self-assembled peptide strongly adheres to regenerated silk fibroin (RSF) substrates through charge-charge interactions. It was observed that in the absence of I3QGK, PC12 cells exhibited poor attachment to RSF films, while for RSF surfaces coated or printed with peptide nanofibers, cellular attachment was significantly improved in terms of both cell density and morphology. AFM results revealed that peptide nanofibers can promote the generation of axons and terminal buttons of PC12 cells, indicating that I3QGK nanofibers not only promote cellular attachment but also facilitate differentiation into neuronal phenotypes. Inkjet printing allows complex patterning of peptide nanofibers onto RSF substrates, which enabled us to engineer cell alignment and provide an opportunity to direct axonal development in vitro. The live/dead assay showed that printed I3QGK patterns exhibit no cytotoxicity to PC12 cells demonstrating potential for future nerve tissue engineering applications

U(1) Gauge Field of the Kaluza-Klein Theory in the Presence of Branes

We investigate the zero mode dimensional reduction of the Kaluza-Klein unifications in the presence of a single brane in the infinite extra dimension. We treat the brane as fixed, not a dynamical object, and do not require the orbifold symmetry. It seems that, contrary to the standard Kaluza-Klein models, the 4D effective action is no longer invariant under the U(1) gauge transformations due to the explicit breaking of isometries in the extra dimension by the brane. Surprisingly, however, the linearized perturbation analysis around the RS vacuum shows that the Kaluza-Klein gauge field does possess the U(1) gauge symmetry at the linear level. In addition, the graviscalar also behaves differently from the 4D point of view. Some physical implications of our results are also discussed.Comment: 10 pages, revtex, no figure, version to appear in Phys. Rev. D, possible caveats of our results due to the zero mode ansatz we used are explained in more detai

Magnetic alginate/chitosan nanoparticles for targeted delivery of curcumin into human breast cancer cells.

Curcumin is a promising anti-cancer drug, but its applications in cancer therapy are limited, due to its poor solubility, short half-life and low bioavailability. In this study, curcumin loaded magnetic alginate/chitosan nanoparticles were fabricated to improve the bioavailability, uptake efficiency and cytotoxicity of curcumin to Human Caucasian Breast Adenocarcinoma cells (MDA-MB-231). Alginate and chitosan were deposited on Fe₃O₄ magnetic nanoparticles based on their electrostatic properties. The nanoparticle size ranged from 120⁻200 nm, within the optimum range for drug delivery. Controllable and sustained release of curcumin was obtained by altering the number of chitosan and alginate layers on the nanoparticles. Confocal fluorescence microscopy results showed that targeted delivery of curcumin with the aid of a magnetic field was achieved. The fluorescence-activated cell sorting (FACS) assay indicated that MDA-MB-231 cells treated with curcumin loaded nanoparticles had a 3⁻6 fold uptake efficiency to those treated with free curcumin. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay indicated that the curcumin loaded nanoparticles exhibited significantly higher cytotoxicity towards MDA-MB-231 cells than HDF cells. The sustained release profiles, enhanced uptake efficiency and cytotoxicity to cancer cells, as well as directed targeting make MACPs promising candidates for cancer therapy