YV-plasty in the treatment of patients with recurrent bladder neck stenosis

Introduction. Bladder neck stenosis (BNS) is a late complication of surgical treatment for benign prostatic hyperplasia. Available methods of endoscopic correction in primary BNS have limited effectiveness, while in recurrent cases their use does not lead to satisfactory results at all. YV-plasty of the bladder neck (BN) is one of the available methods of treatment for recurrent BNS.Purpose of the study. To evaluate the treatment results of patients with recurrent BNS using endovideoscopic YV-plasty of the BN.Materials and methods. We retrospectively analyzed the treatment results of 8 patients with recurrent BNS who underwent endovideoscopic YV-plasty of the BN in the Urology Division No.1 of the St. Luke St. Petersburg Clinical Hospital from 2019 to 2021.Results. Endovideoscopic YV-plasty of the bladder neck was successfully performed in all 8 patients. The mean preoperative Qmax was 3.7 ml/s (1.8 – 5.7). At 6 months after surgery, the mean Qmax was 21.4 mL/s (16.7 – 24.1). The mean preoperative I-PSS score was 20.5 (17 – 24). The mean I-PSS score 6 months after surgery was 7.1 (5.0 – 9.0). No cases of de-novo stress urinary incontinence were registered.Conclusions. Endovideoscopic YV-plasty of the BN may be an effective and safe method of treatment of patients with recurrent BNS. However, further studies are needed to obtain long-term results

Capabilities of the GAMMA-400 gamma-ray telescope to detect gamma-ray bursts from lateral directions

The currently developing space-based gamma-ray telescope GAMMA-400 will measure the gamma-ray and electrons + positrons fluxes using the main top-down aperture in the energy range from ~20 MeV to several TeV in the highly elliptic orbit (without shadowing the telescope by the Earth and outside the radiation belts) continuously for a long time. The instrument will provide fundamentally new data on discrete gamma-ray sources, gamma-ray bursts (GRBs), sources and propagation of Galactic cosmic rays and signatures of dark matter due to its unique angular and energy resolutions in the wide energy range. The gamma-ray telescope consists of the anticoincidence system (AC), the converter-tracker (C), the time-of-flight system (S1 and S2), the position-sensitive and electromagnetic calorimeters (CC1 and CC2), the top and bottom scintillation detectors of the calorimeter (S3 and S4) and lateral detectors of the calorimeter (LD). In this paper, the capabilities of the GAMMA-400 gamma-ray telescope to measure fluxes of GRBs from lateral directions of CC2 are analyzed using Monte-Carlo simulations. The analysis is based on second-level trigger construction using signals from S3, CC2, S4 and LD detectors. For checking the numerical algorithm the data from space-based GBM and LAT instruments of the Fermi experiment are used, namely, three long bursts: GRB 080916C, GRB 090902B, GRB 090926A and one short burst GRB 090510A. The obtained results allow us to conclude that from lateral directions the GAMMA-400 space-based gamma-ray telescope will reliably measure the spectra of bright GRBs in the energy range from ~10 to ~100 MeV with the effective area of about 0.13 m2 (for each of the four sides of CC2) and total field of view of about 6 sr.Comment: 19 pages, 18 figures, the paper will be submitted to Advances in Space Researc

Giant penile melanoma

Primary penile melanoma is an extremely rare casuistic pathology associated with a poor prognosis. The article presents a clinical case of massive lesion of the penis with malignant melanoma, and discusses surgical methods for treating this pathology

Revealing the nature of morphological changes in carbon nanotube-polymer saturable absorber under high-power laser irradiation

Composites of single-walled carbon nanotubes (SWNTs) and water-soluble polymers (WSP) are the focus of significant worldwide research due to a number of applications in biotechnology and photonics, particularly for ultrashort pulse generation. Despite the unique possibility of constructing non-linear optical SWNT-WSP composites with controlled optical properties, their thermal degradation threshold and limit of operational power remain unexplored. In this study, we discover the nature of the SWNT-polyvinyl alcohol (PVA) film thermal degradation and evaluate the modification of the composite properties under continuous high-power ultrashort pulse laser operation. Using high-precision optical microscopy and micro-Raman spectroscopy, we have examined SWNT-PVA films before and after continuous laser radiation exposure (up to 40 hours) with a maximum optical fluence of 2.3 mJ·cm−2. We demonstrate that high-intensity laser radiation results in measurable changes in the composition and morphology of the SWNT-PVA film due to efficient heat transfer from SWNTs to the polymer matrix. The saturable absorber modification does not affect the laser operational performance. We anticipate our work to be a starting point for more sophisticated research aimed at the enhancement of SWNT-PVA films fabrication for their operation as reliable saturable absorbers in high-power ultrafast lasers

Первый опыт выполнения трансперинеальной биопсии предстательной железы без антибиотикопрофилактики

Objective: to study the safety of omitting the antibiotic prophylaxis before transperineal prostate biopsy.Materials and methods. The prospective randomized study included data, obtained during the diagnostical process of 85 patients, who underwent transperineal prostate biopsy in 2020. In the control group (n = 50) patients received 1 g Ceftriaxone IV 1 h before the biopsy. In the study group (n = 35) biopsy was performed without previous antibacterial prophylaxis. Age median was 63.2 (52-75) years.Results. No significant differences in the infection complications rate (UTI, soft tissues infections, prostatitis, fever, sepsis) were obtained between the groups. No patient developed UTI, prostatitis or sepsis, confirmed with urine culture.Conclusion. Performing transperineal prostate biopsy without antibiotic prophylaxis seems to be a safe alternative to common prophylaxis regiments, dedicated to infection complications prevention after prostate biopsy.Цель исследования - оценить безопасность проведения трансперинеальной биопсии предстательной железы без антибиотикопрофилактики.Материалы и методы. В проспективное рандомизированное исследование включены данные, полученные в ходе диагностического обследования 85 пациентов, которым с января по декабрь 2020 г. была выполнена промежностная биопсия предстательной железы. Пациенты контрольной группы (n = 50) за 1 ч до биопсии получали 1 г цефтриаксона внутривенно, а пациентам исследуемой группы (n = 35) антибиотикопрофилактика до манипуляции не проводилась. Медиана возраста пациентов составила 63,2 (52-75) года.Результаты. Достоверных различий в частоте возникновения инфекционных осложнений (инфекция мочевых путей, инфекция мягких тканей промежности, простатит, лихорадка, сепсис) между группами не получено. Ни у одного пациента не зафиксировано мочевых инфекций и простатита, подтвержденных данными культурального исследования, а также сепсиса.Заключение. Проведение трансперинеальной биопсии предстательной железы без использования антибиотикопрофилактики представляется безопасной альтернативой привычной трансректальной биопсии с антибактериальной профилактикой инфекционных осложнений, возникающих после данной процедуры

High power Q-switched thulium doped fibre laser using carbon nanotube polymer composite saturable absorber

We have proposed and demonstrated a Q-switched Thulium doped bre laser (TDFL) with a ‘Yin-Yang’ all- bre cavity scheme based on a combination of nonlinear optical loop mirror (NOLM) and nonlinear ampli ed loop mirror (NALM). Unidirectional lasing operation has been achieved without any intracavity isolator. By using a carbon nanotube polymer composite based saturable absorber (SA), we demonstrated the laser output power of ~197 mW and pulse energy of 1.7 μJ. To the best of our knowledge, this is the highest output power from a nanotube polymer composite SA based Q-switched Thulium doped bre laser

Современные подходы к таргетной биопсии предстательной железы

Prostate cancer (PCa) is in second place in oncological morbidity in males and is the fifth leading cause of death among the world's population. According to current world statistics, over the past 20 years there has been an increase in primary morbidity, as well as mortality from PCa. The key to diagnosing PCa is a prostate biopsy. Nevertheless, a systemic biopsy under transrectal ultrasound control is the subject of discussion and debate in oncourology, as it has significant drawbacks that affect the qualitative result of the diagnosis of PCa. Given the importance of adequate and staged PCa, various methods of targeted biopsy under magnetic resonance control have been proposed.This review will examine the main features and significance of targeted prostate biopsy, as well as the role of magnetic resonance imaging in the early diagnosis of PCa. The method of targeted biopsy of the prostate gland can improve the detection of PCa in relation to clinically significant forms. In addition, this method is extremely promising and requires further study to further improve the quality of early diagnosis of PCa, especially when selecting patients for radical surgical treatment.Рак предстательной железы (РПЖ) занимает 2-е место в структуре онкологической заболеваемости мужчин и 5-е место среди причин смерти населения в мире. Согласно данным мировой статистики в течение последних 20 лет отмечается рост первичной заболеваемости РПЖ, а также смертности от него. Основным методом диагностики РПЖ является биопсия предстательной железы. Тем не менее системная биопсия под трансректальным ультразвуковым контролем остается предметом дискуссии в онкоурологии, так как имеет значимые недостатки, которые влияют на качественный результат диагностики РПЖ. С учетом важности стадирования данного заболевания были предложены различные способы прицельной биопсии под магнитно-резонансным контролем.В настоящем обзоре рассмотрены основные особенности и значимость таргетной биопсии предстательной железы, а также роль магнитно-резонансной томографии в ранней диагностике РПЖ. Таргетная биопсия предстательной железы позволяет улучшить показатели выявления РПЖ в отношении клинически значимых форм. Данный способ является крайне перспективным и требует дальнейшего изучения для дальнейшего повышения качества ранней диагностики РПЖ, особенно при отборе пациентов для радикального хирургического лечения

Microbiological nutrient media the new format in the veterinary-sanitary assessment food and raw materials of animal origin

The main task of veterinary-sanitary examination is to prevent infectious and parasitic diseases that spread among humans and animals through food, feed and industrial products of animal and vegetable origin. This is very important conduct microbiological raw material quality control, food production and disinfection measures carried out, aimed at the reorganization of the production environment. In this connection, development of methods acquires relevance rapid microbiological analysis to identify organisms of sanitary illustrative and other pathogens in a variety of materials. The aim of this work is the comparative study of the effectiveness of the practical use of classical bacteriological culture media and nutrient media of a new format in the veterinary and sanitary evaluation of food and animal feed. As part of this work the traditional media (agar Baird-Parker) and culture media of the new format - 3M™ Petrifilm™ Staph Express Count Plate (STX) were subjected to comparative study in terms of sensitivity and the time required to identify cells S. aureus . The procedures described in ISO 31746-2012 and MUK 42.2884-11 were taken as research algorithms. For the purity of the experiment using artificially contaminated with Staphylococcus aureus cells of the raw milk of cows. 3M™ Petrifilm™ Staph Express Count Plate (STX) may be used in the food industry and regulatory authorities in monitoring to obtain objective information on the contamination of raw materials and food products dangerous pathogens in a very short period of time. This in turn is necessary for the removal of low-quality products from the retail network and avoid poor-quality raw materials to produce products without heat obrabotku. Takzhe it should be noted that due to the simplicity of seeding procedure there is no need for qualified personnel at the stage of sowing and the initial evaluation results. Also achieved significant savings in time, consumables and media at the stage of the primary planting material using the 3M™ Petrifilm™