Disturbance and Input-Output Decoupling of Systems

The disturbance decoupling and the simultaneous disturbance and input–output decoupling problems for singular systems are considered in the context of the matrix fraction description (MFD) of the system. Solvability conditions are obtained in terms of the composite matrix of a column reduced MFD of the system, a characterisation of the fixed poles of both problems is given and it is shown that the remaining poles can be arbitrarily assigned

Unimodular equivalence and similarity for linear systems

The problem of finding the mapping between unimoduar transformations relating two minimal matrix fraction descriptions (MFDs) of a transfer function, and the similarity transformations relating the respective minimal state-space representations is considered. It is shown that the problem is equivalent to finding the relation of MFDs of the input-state transfer functions of the two systems. This relation turns out to be an equivalence relation involving the unimodular and the similarity matrices relating the MFDs and the state-space systems, respectively. A canonical form for MFDs under this equivalence relation is obtained and it is shown that it leads to a canonical state-space representation, via a realisation procedure

Orientation of Implicit State Space Models and the Partitioning of Kronecker Structure

Early stages modelling of processes involves issues of classification of variables into inputs, outputs and internal variables, referred to as Model Orientation Problem (MOP) which may be addressed on state space implicit, or matrix pencil descriptions. Defining orientation is equivalent to producing state space models of the regular or singular type. In this paper we consider autonomous differential descriptions defined by matrix pencils and then search for strict equivalence transformations which introduce the partitioning of the implicit vector into states and possible inputs and outputs, referred to as system orientation. The Kronecker invariant structure of the matrix pencil description is shown to be central to the solution of system orientation and this is expressed as a problem of classification and partitioning of the Kronecker invariants. It is shown that the types of Kronecker invariants characterise the nature of the system orientation solutions. Studying the conditions, under which such oriented models may be derived, as well as their structural properties in terms of the Kronecker structure, is the issue considered here

Atypical Mycobacterial Infection Presenting as Persistent Skin Lesion in a Patient with Ulcerative Colitis

Immunosuppressive drugs are commonly used for the treatment of inflammatory bowel disease. Patients receiving immunosuppressants are susceptible to a variety of infections with opportunistic pathogens. We present a case of skin infection with Mycobacterium chelonae in a 60-year-old Caucasian woman with ulcerative colitis who had been treated with corticosteroids and azathioprine. The disease manifested with fever and rash involving the right leg. Infliximab was administered due to a presumptive diagnosis of pyoderma gangrenosum, leading to worsening of the clinical syndrome and admission to our hospital. Routine cultures from various sites were all negative. However, Ziehl-Neelsen staining of pus from the lesions revealed acid-fast bacilli, and culture yielded a rapidly growing mycobacterium further identified as M. chelonae. The patient responded to a clarithromycin-based regimen. Clinicians should be aware of skin lesions caused by atypical mycobacteria in immunocompromised patients with inflammatory bowel disease. Furthermore, they should be able to thoroughly investigate and promptly treat these conditions

P73 Preliminary results of the Study of Acute Liver Transplant (SALT): NSAID exposure and risk of acute liver failure leading to transplantation in 7 European countries

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The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population

The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified

Impact of Diabetes Susceptibility Loci on Progression From Pre-Diabetes to Diabetes in At-Risk Individuals of the Diabetes Prevention Trial–Type 1 (DPT-1)

OBJECTIVE—The unfolding of type 1 diabetes involves a number of steps: defective immunological tolerance, priming of anti-islet autoimmunity, and destruction of insulin-producing β-cells. A number of genetic loci contribute to susceptibility to type 1 diabetes, but it is unclear which stages of the disease are influenced by the different loci. Here, we analyzed the frequency of type 1 diabetes–risk alleles among individuals from the Diabetes Prevention Trial–Type 1 (DPT-1) clinical trial, which tested a preventive effect of insulin in at-risk relatives of diabetic individuals, all of which presented with autoimmune manifestations but only one-third of which eventually progressed to diabetes