6,212 research outputs found
Giant Magnetic Moments of Nitrogen Stabilized Mn Clusters and Their Relevance to Ferromagnetism in Mn Doped GaN
Using first principles calculations based on density functional theory, we
show that the stability and magnetic properties of small Mn clusters can be
fundamentally altered by the presence of nitrogen. Not only are their binding
energies substantially enhanced, but also the coupling between the magnetic
moments at Mn sites remains ferromagnetic irrespective of their size or shape.
In addition, these nitrogen stabilized Mn clusters carry giant magnetic moments
ranging from 4 Bohr magnetons in MnN to 22 Bohr magnetons in Mn_5N. It is
suggested that the giant magnetic moments of Mn_xN clusters may play a key role
in the ferromagnetism of Mn doped GaN which exhibit a wide range (10K - 940K)
of Curie temperatures
Theoretical He I Emissivities in the Case B Approximation
We calculate the He I case B recombination cascade spectrum using improved
radiative and collisional data. We present new emissivities over a range of
electron temperatures and densities. The differences between our results and
the current standard are large enough to have a significant effect not only on
the interpretation of observed spectra of a wide variety of objects but also on
determinations of the primordial helium abundance.Comment: Accepted to ApJ
The employee as 'Dish of the Dayâ:human resource management and the ethics of consumption
This article examines the ethical implications of the growing integration of consumption into the heart of the employment relationship. Human resource management (HRM) practices increasingly draw upon the values and practices of consumption, constructing employees as the âconsumersâ of âcafeteria-styleâ benefits and development opportunities. However, at the same time employees are expected to market themselves as items to be consumed on a corporate menu. In relation to this simultaneous position of consumer/consumed, the employee is expected to actively engage in the commodification of themselves, performing an appropriate organizational identity as a necessary part of being a successful employee. This article argues that the relationship between HRM and the simultaneously consuming/consumed employee affects the conditions of possibility for ethical relations within organizational life. It is argued that the underlying âethosâ for the integration of consumption values into HRM practices encourages a self-reflecting, self-absorbed subject, drawing upon a narrow view of individualised autonomy and choice. Referring to Levinasâ perspective that the primary ethical relation is that of responsibility and openness to the Other, it is concluded that these HRM practices affect the possibility for ethical being
Moderate Resolution Spectroscopy For The Space Infrared Telescope Facility (SIRTF)
A conceptual design for an infrared spectrometer capable of both low resolution (Îť/Î-Îť = 50; 2.5-200 microns) and moderate resolution (1000; 4-200 microns) and moderate resolution (1000; 4-200 microns) has been developed. This facility instrument will permit the spectroscopic study in the infrared of objects ranging from within the solar system to distant galaxies. The spectroscopic capability provided by this instrument for SIRTF will give astronomers orders of magnitude greater sensitivity for the study of faint objects than had been previously available. The low resolution mode will enable detailed studies of the continuum radiation. The moderate resolution mode of the instrument will permit studies of a wide range of problems, from the infrared spectral signatures of small outer solar system bodies such as Pluto and the satellites of the giant planets, to investigations of more luminous active galaxies and QS0s at substantially greater distances. A simple design concept has been developed for the spectrometer which supports the science investigation with practical cryogenic engineering. Operational flexibility is preserved with a minimum number of mechanisms. The five modules share a common aperture, and all gratings share a single scan mechanism. High reliability is achieved through use of flight-proven hardware concepts and redundancy. The design controls the heat load into the SIRTF cryogen, with all heat sources other than the detectors operating at 7K and isolated from the 4K cold station. Two-dimensional area detector arrays are used in the 2.5-120Îźm bands to simultaneously monitor adjacent regions in extended objects and to measure the background near point sources
Phase transition curves for mesoscopic superconducting samples
We compute the phase transition curves for mesoscopic superconductors.
Special emphasis is given to the limiting shape of the curve when the magnetic
flux is large. We derive an asymptotic formula for the ground state of the
Schr\"odinger equation in the presence of large applied flux. The expansion is
shown to be sensitive to the smoothness of the domain. The theoretical results
are compared to recent experiments.Comment: 8 pages, 1 figur
Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation.
Women exposed to a variety of viral and bacterial infections during pregnancy have an increased risk of giving birth to a child with autism, schizophrenia or other neurodevelopmental disorders. Preclinical maternal immune activation (MIA) models are powerful translational tools to investigate mechanisms underlying epidemiological links between infection during pregnancy and offspring neurodevelopmental disorders. Our previous studies documenting the emergence of aberrant behavior in rhesus monkey offspring born to MIA-treated dams extends the rodent MIA model into a species more closely related to humans. Here we present novel neuroimaging data from these animals to further explore the translational potential of the nonhuman primate MIA model. Nine male MIA-treated offspring and 4 controls from our original cohort underwent in vivo positron emission tomography (PET) scanning at approximately 3.5-years of age using [18F] fluoro-l-m-tyrosine (FMT) to measure presynaptic dopamine levels in the striatum, which are consistently elevated in individuals with schizophrenia. Analysis of [18F]FMT signal in the striatum of these nonhuman primates showed that MIA animals had significantly higher [18F]FMT index of influx compared to control animals. In spite of the modest sample size, this group difference reflects a large effect size (Cohen's dâ=â0.998). Nonhuman primates born to MIA-treated dams exhibited increased striatal dopamine in late adolescence-a hallmark molecular biomarker of schizophrenia. These results validate the MIA model in a species more closely related to humans and open up new avenues for understanding the neurodevelopmental biology of schizophrenia and other neurodevelopmental disorders associated with prenatal immune challenge
Liquid racism and the Danish Prophet Muhammad cartoons
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 The Author.This article examines reactions to the October 2005 publication of the Prophet Muhammad cartoons in the Danish newspaper Jyllands-Posten. It does so by using the concept of âliquid racismâ. While the controversy arose because it is considered blasphemous by many Muslims to create images of the Prophet Muhammad, the article argues that the meaning of the cartoons is multidimensional, that their analysis is significantly more complex than most commentators acknowledge, and that this complexity can best be addressed via the concept of liquid racism. The article examines the liquidity of the cartoons in relation to four readings. These see the cartoons as: (1) a criticism of Islamic fundamentalism; (2) blasphemous images; (3) Islamophobic and racist; and (4) satire and a defence of freedom of speech. Finally, the relationship between postmodernity and the rise of fundamentalism is discussed because the cartoons, reactions to them, and Islamic fundamentalism, all contain an important postmodern dimension.ESR
The concept of solidarity: emerging from the theoretical shadows?
The concept of solidarity has been relatively neglected by social scientists since Durkheim's pioneering work in the late 19th century. The discipline of politics has been guilty of overlooking this 'subjective' element of community life, but recent works by Stjernø and Brunkhorst reflect a growing awareness of the theoretical significance of the concept. Whereas early liberal attempts to theorise solidarity took the nation state to be the appropriate community for its realisation, the emergence of globalisation raises the possibility of human solidarity developing in the global community. Traditional forms of solidarity have been dissipated by the social changes accompanying globalisation, but they were often locked into the defence of particular interests. New forms may be emerging to rekindle the broader vision of human solidarity. Recent work by writers such as Habermas, Honneth, Rorty and Touraine focuses on widening and deepening democratic participation and/or the articulation of our ethical obligations in various ways. It is argued here that these perspectives need to be supplemented by a radical humanist approach grounded in a normative theory of human self-realisation
â20 tins of Stella for a fiverâ: The making of class through Labour and Coalition government alcohol policy
Alcohol use in the UK has been a key concern to both the Labour and Coalition governments, and commands considerable attention in the media and academic discussions. This article analyses how recent government policy discussions have defined particular forms of drinking as problematic, and how these definitions and associated policy initiatives can be seen as part of a wider symbolic economy through which people come to be valued differently, incorporating ideas of economic, cultural and social capital. Therefore, I argue that government policies and discussions of drinking are a key way in which class is constituted in contemporary Britain
Intracranial and extracranial efficacy of lorlatinib in patients with ALK-positive non-small-cell lung cancer previously treated with second-generation ALK TKIs
Lorlatinib; Cà ncer de pulmó de cèl¡lules no petites; ALK TKI de segona generacióLorlatinib; Cåncer de pulmón de cÊlulas no pequeùas; ALK TKI de segunda generaciónLorlatinib; Non-small-cell lung cancer; Second-generation ALK TKIsBackground
Lorlatinib, a potent, brain-penetrant, third-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI), has substantial activity against ALK-positive non-small-cell lung cancer (NSCLC). This study assessed the overall, intracranial, and extracranial efficacy of lorlatinib in ALK-positive NSCLC that progressed on second-generation ALK TKIs.
Patients and methods
In the ongoing phase II study (NCT01970865), patients with ALK-positive advanced NSCLC treated with âĽ1 prior second-generation ALK TKI Âą chemotherapy were enrolled in expansion cohorts (EXP) based on treatment history. Overall, intracranial and extracranial antitumor activity were assessed independently per modified Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.
Results
Of the 139 patients with âĽ1 prior second-generation ALK TKI (EXP3B-5), 28 received one prior second-generation ALK TKI (EXP3B), 65 two prior ALK TKIs (EXP4), and 46 three prior ALK TKIs (EXP5). In EXP3B-5, the objective response rate (ORR) [95% confidence intervals] was 39.6% (31.4-48.2), intracranial ORR (IC-ORR) was 56.1% (42.4-69.3), extracranial ORR (EC-ORR) was 36.7% (28.7-45.3), median duration of response (DOR) was 9.6 months [5.6-16.7; IC-DOR, 12.4 (6.0-37.1); EC-DOR, 9.7 (6.1-33.3)], median progression-free survival was 6.6 (5.4-7.4) months, and median overall survival was 20.7 months (16.1-30.3). In EXP3B, the ORR was 42.9% (24.5-62.8), the IC-ORR was 66.7% (29.9-92.5), and the EC-ORR was 32.1% (15.9-52.4). In EXP4 and EXP5, the ORR was 38.7% (29.6-48.5), the IC-ORR was 54.2% (39.2-68.6), and the EC-ORR was 37.8% (28.8-47.5).
Conclusions
Lorlatinib had clinically meaningful intracranial and extracranial antitumor activity in the post-second-generation ALK TKI setting, with elevated intracranial versus extracranial ORR, particularly in patients with fewer lines of therapy.This work was supported by Pfizer Inc. (no grant number)
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