13,396 research outputs found
Kondo effect in complex mesoscopic structures
We study the Kondo effect of a quantum dot placed in a complex mesoscopic
structure. Assuming that electronic interactions are taking place solely on the
dot, and focusing on the infinite Hubbard interaction limit, we use a
decoupling scheme to obtain an explicit analytic approximate expression for the
dot Green function, which fulfills certain Fermi-liquid relations at zero
temperature. The details of the complex structure enter into this expression
only via the self-energy for the non-interacting case. The effectiveness of the
expression is demonstrated for the single impurity Anderson model and for the
T-shaped network.Comment: 12 pages 6 figure
Submillimeter continuum observations of Sagittarius B2 at subarcsecond spatial resolution
We report the first high spatial resolution submillimeter continuum
observations of the Sagittarius B2 cloud complex using the Submillimeter Array
(SMA). With the subarcsecond resolution provided by the SMA, the two massive
star-forming clumps Sgr B2(N) and Sgr B2(M) are resolved into multiple compact
sources. In total, twelve submillimeter cores are identified in the Sgr B2(M)
region, while only two components are observed in the Sgr B2(N) clump. The gas
mass and column density are estimated from the dust continuum emission. We find
that most of the cores have gas masses in excess of 100 M and column
densities above 10 cm. The very fragmented appearance of Sgr
B2(M), in contrast to the monolithic structure of Sgr B2 (N), suggests that the
former is more evolved. The density profile of the Sgr B2(N)-SMA1 core is well
fitted by a Plummer density distribution. This would lead one to believe that
in the evolutionary sequence of the Sgr B2 cloud complex, a massive star forms
first in an homogeneous core, and the rest of the cluster forms subsequently in
the then fragmenting structure.Comment: 4 pages, 2 figures, accepted by A&A letter
Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3β activation
published_or_final_versio
Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury
published_or_final_versio
Static analysis of elastic cable structures under mechanical load using discrete catenary theory
Two Kinds of Iterative Solutions for Generalized Sombrero-shaped Potential in -dimensional Space
Based on two different iteration procedures the groundstate wave functions
and energies for N-dimensional generalized Sombrero-shaped potentials are
solved. Two kinds of trial functions for the iteration procedure are defined.
The iterative solutions are convergent nicely to consistent results for
different choices of iteration procedures and trial functions.Comment: 16 pages, 3 figure
Improved lattice QCD with quarks: the 2 dimensional case
QCD in two dimensions is investigated using the improved fermionic lattice
Hamiltonian proposed by Luo, Chen, Xu, and Jiang. We show that the improved
theory leads to a significant reduction of the finite lattice spacing errors.
The quark condensate and the mass of lightest quark and anti-quark bound state
in the strong coupling phase (different from t'Hooft phase) are computed. We
find agreement between our results and the analytical ones in the continuum.Comment: LaTeX file (including text + 10 figures
Intra-articular spine injections of steroid as a contributing factor to glaucoma
Letter to the editorQueena Qin, Robert J. Casson, Daniel Myers, Sudha Cugat
PDZK1 inhibits the development and progression of renal cell carcinoma by suppression of SHP-1 phosphorylation
Renal cell carcinoma (RCC) is one of the most aggressive urologic cancers, however, the mechanism on supporting RCC carcinogenesis is still not clear. By using gene expression profile analysis and functional clustering, PDZ domain-containing 1 (PDZK1) was revealed to be downregulated in human clear cell renal cell carcinoma (ccRCC) samples, which was also verified in several independent public ccRCC data sets. Using PDZK1 overexpression and knockdown models in ccRCC cell lines, we demonstrated that PDZK1 inhibited cell proliferation, cell cycle G1/S phase transition, cell migration and invasion, indicating a tumor-suppressor role in the development and progression of ccRCC. Our study further demonstrated that PDZK1 inhibited cell proliferation and migration of ccRCC via targeting SHP-1. PDZK1 was further identified to suppress cell proliferation by blocking SHP-1 phosphorylation at Tyr536 via inhibition of the association between SHP-1 and PLCβ3, and then retarding Akt phosphorylation and promoting STAT5 phosphorylation in ccRCC cells. Moreover, the inhibitive effects of PDZK1 on SHP-1 phosphorylation and the tumor growth were verified in vivo by xenograft tumor studies. Accordingly, PDZK1 expression was negatively correlated with SHP-1 activation and phosphorylation, advanced pathologic stage, tumor weight and size, and prognosis of ccRCC patients. These findings have provided first lines of evidences that PDZK1 expression is negatively correlated with SHP-1 activation and poor clinical outcomes in ccRCC. PDZK1 was identified as a novel tumor suppressor in ccRCC by negating SHP-1 activity
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