Pushing the precision limit of ground-based eclipse photometry

Until recently, it was considered by many that ground-based photometry could not reach the high cadence sub-mmag regime because of the presence of the atmosphere. Indeed, high frequency atmospheric noises (mainly scintillation) limit the precision that high SNR photometry can reach within small time bins. If one is ready to damage the sampling of his photometric time-series, binning the data (or using longer exposures) allows to get better errors, but the obtained precision will be finally limited by low frequency noises. To observe several times the same planetary eclipse and to fold the photometry with the orbital period is thus generally considered as the only option to get very well sampled and precise eclipse light curve from the ground. Nevertheless, we show here that reaching the sub-mmag sub-min regime for one eclipse is possible with a ground-based instrument. This has important implications for transiting planets characterization, secondary eclipses measurement and small planets detection from the ground.Comment: Transiting Planets Proceeding IAU Symposium No.253, 2008. 7 pages, 4 figure

Condensation temperature of interacting Bose gases with and without disorder

The momentum-shell renormalization group (RG) is used to study the condensation of interacting Bose gases without and with disorder. First of all, for the homogeneous disorder-free Bose gas the interaction-induced shifts in the critical temperature and chemical potential are determined up to second order in the scattering length. The approach does not make use of dimensional reduction and is thus independent of previous derivations. Secondly, the RG is used together with the replica method to study the interacting Bose gas with delta-correlated disorder. The flow equations are derived and found to reduce, in the high-temperature limit, to the RG equations of the classical Landau-Ginzburg model with random-exchange defects. The random fixed point is used to calculate the condensation temperature under the combined influence of particle interactions and disorder.Comment: 7 pages, 2 figure

The Fate of Local Food Systems in the Global Industrialization Market: Food and Social Justice in the Rural South

This paper investigates the connection between local food systems, health disparities, and social justice in the rural South. It begins with the relationship between food insecurity and health disparities that disproportionately affect racial and ethnic minority populations, and non-minority women and children. First, we discuss the concept of health disparities within the context of bioethics and public health ethics in order to explore the link between the food system and health as a social justice issue. Second, we define health disparities and discuss how they have historically plagued and disadvantaged racial minority populations. Third, we examine these disparities within the context of the structure of the food system and the related social justice issues. We conclude that food insecurity in the rural south is ethically unacceptable because it harms the disadvantaged populations living in these areas. It worsens their vulnerability, truncates their flourishing, and makes their optimal health a mirage

MR coil sensitivity inhomogeneity correction for plaque characterization in carotid arteries

We are involved in a comprehensive program to characterize atherosclerotic disease using multiple MR images having different contrast mechanisms (T1W, T2W, PDW, magnetization transfer, etc.) of human carotid and animal model arteries. We use specially designed intravascular and surface array coils that give high signal-to-noise but suffer from sensitivity inhomogeneity. With carotid surface coils, challenges include: (1) a steep bias field with an 80% change; (2) presence of nearby muscular structures lacking high frequency information to distinguish bias from anatomical features; (3) many confounding zero-valued voxels subject to fat suppression, blood flow cancellation, or air, which are not subject to coil sensitivity; and (4) substantial noise. Bias was corrected using a modification of the adaptive fuzzy c-mean method reported by Pham et al. (IEEE TMI, 18:738-752), whereby a bias field modeled as a mechanical membrane was iteratively improved until cluster means no longer changed. Because our images were noisy, we added a noise reduction filtering step between iterations and used approximate to5 classes. In a digital phantom having a bias field measured from our MR system, variations across an area comparable to a carotid artery were reduced from 50% t

Neuregulin-1 attenuates mortality associated with experimental cerebral malaria.

BackgroundCerebral Malaria (CM) is a diffuse encephalopathy caused by Plasmodium falciparum infection. Despite availability of antimalarial drugs, CM-associated mortality remains high at approximately 30% and a subset of survivors develop neurological and cognitive disabilities. While antimalarials are effective at clearing Plasmodium parasites they do little to protect against CM pathophysiology and parasite-induced brain inflammation that leads to seizures, coma and long-term neurological sequelae in CM patients. Thus, there is urgent need to explore therapeutics that can reduce or prevent CM pathogenesis and associated brain inflammation to improve survival. Neuregulin-1 (NRG-1) is a neurotrophic growth factor shown to protect against brain injury associated with acute ischemic stroke (AIS) and neurotoxin exposure. However, this drug has not been tested against CM-associated brain injury. Since CM-associated brain injuries and AIS share similar pathophysiological features, we hypothesized that NRG-1 will reduce or prevent neuroinflammation and brain damage as well as improve survival in mice with late-stage experimental cerebral malaria (ECM).MethodsWe tested the effects of NRG-1 on ECM-associated brain inflammation and mortality in P. berghei ANKA (PbA)-infected mice and compared to artemether (ARM) treatment; an antimalarial currently used in various combination therapies against malaria.ResultsTreatment with ARM (25 mg/kg/day) effectively cleared parasites and reduced mortality in PbA-infected mice by 82%. Remarkably, NRG-1 therapy (1.25 ng/kg/day) significantly improved survival against ECM by 73% despite increase in parasite burden within NRG-1-treated mice. Additionally, NRG-1 therapy reduced systemic and brain pro-inflammatory factors TNFalpha, IL-6, IL-1alpha and CXCL10 and enhanced anti-inflammatory factors, IL-5 and IL-13 while decreasing leukocyte accumulation in brain microvessels.ConclusionsThis study suggests that NRG-1 attenuates ECM-associated brain inflammation and injuries and may represent a novel supportive therapy for the management of CM