6,358 research outputs found

    Effect of Ozone Addition on Combustion Efficiency of Hydrogen: Liquid-Oxygen Propellant in Small Rockets

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    An experimental study shows that 2 percent by weight ozone in oxygen has little effect on overall reactivity for a range of oxidant-fuel weight ratios from 1 to 6. This conclusion is based on characteristic-velocity measurements in 200-pound-thrust chambers at a pressure of 300 pounds per square inch absolute with low-efficiency injectors. The presence of 9 percent ozone in oxygen also did not affect performance in an efficient chamber. Explosions were encountered when equipment or procedure permitted ozone to concentrate locally. These experiments indicate that even small amounts of ozone in oxygen can cause operational problems

    Duality for Jacobi group orbit spaces and elliptic solutions of the WDVV equations

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    From any given Frobenius manifold one may construct a so-called dual structure which, while not satisfying the full axioms of a Frobenius manifold, shares many of its essential features, such as the existence of a prepotential satisfying the WDVV equations of associativity. Jacobi group orbit spaces naturally carry the structures of a Frobenius manifold and hence there exists a dual prepotential. In this paper this dual prepotential is constructed and expressed in terms of the elliptic polylogarithm function of Beilinson and Levin

    Selection Of A Novel Aptamer Against Vitronectin Using Capillary Electrophoresis And Next Generation Sequencing

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    Breast cancer (BC) results in ≃40,000 deaths each year in the United States and even among survivors treatment of the disease may have devastating consequences, including increased risk for heart disease and cognitive impairment resulting from the toxic effects of chemotherapy. Aptamer-mediated drug delivery can contribute to improved treatment outcomes through the selective delivery of chemotherapy to BC cells, provided suitable cancer-specific antigens can be identified. We report here the use of capillary electrophoresis in conjunction with next generation sequencing to develop the first vitronectin (VN) binding aptamer (VBA-01; Kd 405 nmol/l, the first aptamer to vitronectin (VN; Kd = 405 nmol/l), a protein that plays an important role in wound healing and that is present at elevated levels in BC tissue and in the blood of BC patients relative to the corresponding nonmalignant tissues. We used VBA-01 to develop DVBA-01, a dimeric aptamer complex, and conjugated doxorubicin (Dox) to DVBA-01 (7:1 ratio) using pH-sensitive, covalent linkages. Dox conjugation enhanced the thermal stability of the complex (60.2 versus 46.5°C) and did not decrease affinity for the VN target. The resulting DVBA-01-Dox complex displayed increased cytotoxicity to MDA-MB-231 BC cells that were cultured on plasticware coated with VN (1.8 × 10⁻⁶mol/l) relative to uncoated plates (2.4 × 10⁻⁶ mol/l), or plates coated with the related protein fibronectin (2.1 × 10⁻⁶ mol/l). The VBA-01 aptamer was evaluated for binding to human BC tissue using immunohistochemistry and displayed tissue specific binding and apparent association with BC cells. In contrast, a monoclonal antibody that preferentially binds to multimeric VN primarily stained extracellular matrix and vessel walls of BC tissue. Our results indicate a strong potential for using VN-targeting aptamers to improve drug delivery to treat BC

    Void elimination in screen printed thick film dielectric pastes

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    The problem is to understand the mechanisms for the formation and evolution of defects in wet screen printed layers. The primary objective is to know how best to alter the properties of the paste (rather than the geometry of the screen printing process itself) in order to eliminate the defects. With these goals in mind the work done during the Study Group reported here was as follows; to describe a simple model for the closure of craters, a model for the partial closure of vias, a possible mechanism for the formation of pinholes and finally a more detailed consideration of the screen printing process

    Simulating quantum-optical phenomena with cold atoms in optical lattices

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    We propose a scheme involving cold atoms trapped in optical lattices to observe different phenomena traditionally linked to quantum-optical systems. The basic idea consists of connecting the trapped atomic state to a non-trapped state through a Raman scheme. The coupling between these two types of atoms (trapped and free) turns out to be similar to that describing light-matter interaction within the rotating-wave approximation, the role of matter and photons being played by the trapped and free atoms, respectively. We explain in particular how to observe phenomena arising from the collective spontaneous emission of atomic and harmonic oscillator samples such as superradiance and directional emission. We also show how the same setup can simulate Bose-Hubbard Hamiltonians with extended hopping as well as Ising models with long-range interactions. We believe that this system can be realized with state of the art technology

    Measurements of total alkalinity and inorganic dissolved carbon in the Atlantic Ocean and adjacent Southern Ocean between 2008 and 2010

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    Water column dissolved inorganic carbon and total alkalinity were measured during five hydrographic sections in the Atlantic Ocean and Drake Passage. The work was funded through the Strategic Funding Initiative of the UK's Oceans2025 programme, which ran from 2007 to 2012. The aims of this programme were to establish the regional budgets of natural and anthropogenic carbon in the North Atlantic, the South Atlantic, and the Atlantic sector of the Southern Ocean, as well as the rates of change of these budgets. This paper describes in detail the dissolved inorganic carbon and total alkalinity data collected along east–west sections at 47° N to 60° N, 24.5° N, and 24° S in the Atlantic and across two Drake Passage sections. Other hydrographic and biogeochemical parameters were measured during these sections, and relevant standard operating procedures are mentioned here. Over 95% of dissolved inorganic carbon and total alkalinity samples taken during the 24.5° N, 24° S, and the Drake Passage sections were analysed onboard and subjected to a first-level quality control addressing technical and analytical issues. Samples taken along 47° N to 60° N were analysed and subjected to quality control back in the laboratory. Complete post-cruise second-level quality control was performed using cross-over analysis with historical data in the vicinity of measurements, and data were submitted to the CLIVAR and Carbon Hydrographic Data Office (CCHDO), the Carbon Dioxide Information Analysis Center (CDIAC) and and will be included in the Global Ocean Data Analyses Project, version 2 (GLODAP 2), the upcoming update of Key et al. (2004)

    Homogeneous links, Seifert surfaces, digraphs and the reduced Alexander polynomial

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    We give a geometric proof of the following result of Juhasz. \emph{Let aga_g be the leading coefficient of the Alexander polynomial of an alternating knot KK. If ag<4|a_g|<4 then KK has a unique minimal genus Seifert surface.} In doing so, we are able to generalise the result, replacing `minimal genus' with `incompressible' and `alternating' with `homogeneous'. We also examine the implications of our proof for alternating links in general.Comment: 37 pages, 28 figures; v2 Main results generalised from alternating links to homogeneous links. Title change

    Study of the April 20, 2007 CME-Comet Interaction Event with an MHD Model

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    This study examines the tail disconnection event on April 20, 2007 on comet 2P/Encke, caused by a coronal mass ejection (CME) at a heliocentric distance of 0.34 AU. During their interaction, both the CME and the comet are visible with high temporal and spatial resolution by the STEREO-A spacecraft. Previously, only current sheets or shocks have been accepted as possible reasons for comet tail disconnections, so it is puzzling that the CME caused this event. The MHD simulation presented in this work reproduces the interaction process and demonstrates how the CME triggered a tail disconnection in the April 20 event. It is found that the CME disturbs the comet with a combination of a 180180^\circ sudden rotation of the interplanetary magnetic field (IMF), followed by a 9090^\circ gradual rotation. Such an interpretation applies our understanding of solar wind-comet interactions to determine the \textit{in situ} IMF orientation of the CME encountering Encke.Comment: 13 pages, 3 figures, accepted by the ApJ Letter
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