Asynchronous glacier dynamics during the Antarctic Cold Reversal in central Patagonia

We present 14 new 10Be cosmogenic nuclide exposure ages quantifying asynchronous readvances during the Antarctic Cold Reversal from glaciers in the Baker Valley region of central Patagonia. We constrain glacier and ice-dammed palaeolake dynamics using a landsystems approach, concentrating on outlet glaciers from the eastern Northern Patagonian Icefield (NPI) and Monte San Lorenzo (MSL). Soler Glacier (NPI) produced lateral moraines above Lago Bertrand from 15.1 ± 0.7 to 14.0 ± 0.6 ka, when it dammed the drainage of Lago General Carrera/Buenos Aires through Río Baker at a bedrock pinning point. At this time, Soler Glacier terminated into the 400 m “Deseado” level of the ice-dammed palaeolake. Later, Calluqueo Glacier (MSL) deposited subaerial and subaqueous moraines in the Salto Valley near Cochrane at 13.0 ± 0.6 ka. These moraines were deposited in an ice-dammed palaeolake unified through the Baker Valley (Lago Chalenko; 350 m asl). The Salto Valley glaciolacustrine landsystem includes subaqueous morainal banks, ice-scoured bedrock, glacial diamicton plastered onto valley sides, perched delta terraces, kame terraces, ice-contact fans, palaeoshorelines and subaerial push and lateral moraines. Boulders from the subaqueous Salto Moraine became exposed at 12.1 ± 0.6 years, indicating palaeolake drainage. These data show an asynchronous advance of outlet glaciers from the Northern Patagonian Icefield and Monte San Lorenzo during the Antarctic Cold Reversal. These advances occurred during a period of regional climatic cooling, but differential moraine extent and timing of advance was controlled by topography and calving processes

Development and acceptability of a co-produced online intervention to prevent alcohol misuse in adolescents: A think aloud study

Background: The prototype willingness model (PWM) may offer an appropriate basis for explaining and preventing adolescent alcohol misuse. An intervention was developed using a co-production approach, and consisted of an online quiz featuring 10 questions linked to the PWM. Objective: This study sought to determine the acceptability and relevance of the intervention content to young people, to incorporate their feedback into a final version. Methods: A qualitative think aloud study with follow-up semistructured interviews was undertaken with 16 young people aged 11-15 (50%). Transcripts were analyzed using thematic analysis. Results: The following 3 main themes relating the acceptability of the intervention were identified: “challenging expectations of alcohol education”; “motivations for drinking or not drinking,” and “the inevitability of drinking.” Participants found the intervention appealing because it was counter to their expectations. The content appeared to reflect their experiences of social pressure and drinking encounters. There was evidence that a focus on drinker/nondrinker prototypes was too narrow and that because adolescents perceived drinking as inevitable, it would be challenging to enact any plans to resist pressure to drink. Conclusions: An online intervention based on the PWM has the potential to engage and interest adolescents. A wide range of alcohol prototypes should be targeted and a focus on short-term harms should ensure that the intervention is credible to young people

Superoxide radicals can act synergistically with hypochlorite to induce damage to proteins

AbstractActivated phagocytes generate both superoxide radicals via a respiratory burst, and HOCl via the concurrent release of the haem enzyme myeloperoxidase. Amine and amide functions on proteins and carbohydrates are major targets for HOCl, generating chloramines (RNHCl) and chloramides (RC(O)NClR′), which can accumulate to high concentrations (>100 μM). Here we show that superoxide radicals catalyse the decomposition of chloramines and chloramides to reactive nitrogen-centred radicals, and increase the extent of protein fragmentation compared to that observed with either superoxide radicals or HOCl, alone. This synergistic action may be of significance at sites of inflammation, where both superoxide radicals and chloramines/chloramides are formed simultaneously

Varenicline and suicidal behaviour: a cohort study based on data from the General Practice Research Database

Objective To determine whether varenicline, a recently licensed smoking cessation product, is associated with an increased risk of suicide and suicidal behaviour compared with alternative treatments bupropion and nicotine replacement therapy

Variability in bacteriophage and antibiotic sensitivity in serial Pseudomonas aeruginosa isolates from cystic fibrosis airway cultures over 12 months

Antibiotic treatment for Pseudomonas aeruginosa (Pa) in cystic fibrosis is limited in efficacy and may lead to multi-drug resistance (MDR). Alternatives such as bacteriophages are being explored but well designed, and controlled trials are crucial. The rational selection of patients with bacteriophage susceptible infections is required for both safety and efficacy monitoring. We questioned whether bacteriophage susceptibility profiles were constant or variable over time, variability having been reported with antibiotics. Serial Pa isolates (n = 102) from 24 chronically infected cystic fibrosis (CF) patients over one year were investigated with plaque and antibiotic disc diffusion assays. Variable number tandem repeat (VNTR) analysis identified those patients with >1 isolate. A median (range) of 4 (3–6) isolates/patient were studied. Twenty-one (87.5%) individuals had a single VNTR type; three (12.5%) had two VNTR types at different times. Seventy-five percent of isolates were sensitive to bacteriophage at ≥ 1 concentration; 50% of isolates were antibiotic multidrug resistant. Serial isolates, even when representing a single VNTR type, varied in sensitivity to both bacteriophages and antibiotics. The rates of sensitivity to bacteriophage supports the development of this therapy; however, the variability in response has implications for the selection of patients in future trials which must be on the basis of current, not past, isolate testing

A kinetic and theoretical study of the borate catalysed reactions of hydrogen peroxide: the role of dioxaborirane as the catalytic intermediate for a wide range of substrates

Our recent work has provided new insights into the equilibria and species that exist in aqueous solution at different pHs for the boric acid – hydrogen peroxide system, and the role of these species in oxidation reactions. Most recently, (M. C. Durrant, D. M. Davies and M. E. Deary, Org. Biomol. Chem., 2011, 9,7249–7254), we have produced strong theoretical and experimental evidence for the existence of a previously unreported monocyclic three membered peroxide species, dioxaborirane, that is the likely catalytic species in borate mediated electrophilic reactions of hydrogen peroxide in alkaline solution. In the present paper, we extend our study of the borate–peroxide system to look at a wide range of substrates that include substituted dimethyl anilines, methyl-p-tolyl sulfoxide, halides, hydrogen sulfide anion, thiosulfate ,thiocyanate, and hydrazine. The unusual selectivity–reactivity pattern of borate catalysed reactions compared with hydrogen peroxide and inorganic or organic peracids previously observed for theorganic sulfides (D. M. Davies, M. E. Deary, K. Quill and R. A. Smith, Chem.–Eur. J., 2005, 11, 3552–3558) is also seen with substituted dimethyl aniline nucleophiles. This provides evidence that the pattern is not due to any latent electrophilic tendency of the organic sulfides and further supports dioxaborirane being the likely reactive intermediate, thus broadening the applicability of this catalytic system. Moreover, density functional theory calculations on our proposed mechanism involving dioxaborirane are consistent with the experimental results for these substrates. Results obtained at high concentrations of both borate and hydrogen peroxide require the inclusion the diperoxodiborate dianion in the kinetic analysis .A scheme detailing our current understanding of the borate–peroxide system is presented

Effect of the Milky Way on Magellanic Cloud structure

A combination of analytic models and n-body simulations implies that the structural evolution of the Large Magellanic Cloud (LMC) is dominated by its dynamical interaction with the Milky Way. Although expected at some level, the scope of the involvement has significant observational consequences. First, LMC disk orbits are torqued out of the disk plane, thickening the disk and populating a spheroid. The torque results from direct forcing by the Milky Way tide and, indirectly, from the drag between the LMC disk and its halo resulting from the induced precession of the LMC disk. The latter is a newly reported mechanism that can affect all satellite interations. However, the overall torque can not isotropize the stellar orbits and their kinematics remains disk-like. Such a kinematic signature is observed for nearly all LMC populations. The extended disk distribution is predicted to increase the microlensing toward the LMC. Second, the disk's binding energy slowly decreases during this process, puffing up and priming the outer regions for subsequent tidal stripping. Because the tidally stripped debris will be spatially extended, the distribution of stripped stars is much more extended than the HI Magellanic Stream. This is consistent with upper limits to stellar densities in the gas stream and suggests a different strategy for detecting the stripped stars. And, finally, the mass loss over several LMC orbits is predicted by n-body simulation and the debris extends to tens of kiloparsecs from the tidal boundary. Although the overall space density of the stripped stars is low, possible existence of such intervening populations have been recently reported and may be detectable using 2MASS.Comment: 15 pages, color Postscript figures, uses emulateapj.sty. Also available from http://www-astro.phast.umass.edu/~weinberg/weinberg-pubs.htm

Development of an adolescent alcohol misuse intervention based on the Prototype Willingness Model: A Delphi study

Purpose of the paper: The purpose of this paper is to report on the use of the Delphi method to gain expert feedback on the identification of behaviour change techniques (BCTs) and development of a novel intervention to reduce adolescent alcohol misuse, based on the Prototype Willingness Model (PWM) of health risk behaviour. Methodology: Four BCTs based on the PWM were identified and incorporated into a draft intervention that aimed to change alcohol prototypes and enable adolescents to deal with social pressure. Using the Delphi process, successive questionnaires were distributed to 20 international experts to build consensus on the theoretical validity of the intervention. Findings: Fifteen experts completed round one and eleven completed round two of the Delphi study. A high level of consensus was achieved. Four priority areas were identified to improve the intervention: 1) incorporating extra techniques to address social pressure, 2) increasing intensity, 3) providing incentives, and 4) addressing credibility. Limitations: The sample of experts was self-selected and four participants were lost between the first and second round of the study. Implications: The effectiveness of the identified BCTs will be evaluated within an intervention to reduce alcohol misuse in adolescents. Further work should build towards a more unified approach to developing interventions based on the PWM. The Delphi method is likely to be particularly useful when there is no existing consensus about which BCTs to use that reflect certain theoretical constructs or that best target a specific population or behaviour. Originality/ value: This paper is the first to address the identification of specific BCTs based on the PWM and thus makes an important contribution to the application of this model to interventions. This novel application of the Delphi method also makes a useful addition to the growing field of intervention development and design