599 research outputs found
Summary report of Committee B
Topics discussed in this summary include: (1) general aviation and services; (2) aircraft design; and (3) simulation. It was concluded that private pilots need to be more knowledgeable about weather. Improvement is needed in providing general aviation pilots with changes in the weather reporting and forecasting systems. There should also be some simulation of various severe shear profiles in training simulators, although there is still a problem in simulating shear conditions using mathematical models and data
Modulation of extracellular ISG15 signaling by pathogens and viral effector proteins
ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. The signals that lead to the production of extracellular ISG15 and the relationship between its two core functions remain unclear. We show that both epithelial cells and lymphocytes can secrete ISG15, which then signals in either an autocrine or paracrine manner to LFA-1-expressing cells. Microbial pathogens and Toll-like receptor (TLR) agonists result in both IFN-β-dependent and -independent secretion of ISG15, and residues required for ISG15 secretion are mapped. Intracellular ISGylation inhibits secretion, and viral effector proteins, influenza B NS1, and viral de-ISGylases, including SARS-CoV-2 P
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An overview of ISCAT 2000
The Investigation of Sulfur Chemistry in the Antarctic Troposphere (ISCAT) took place over the timer period of 15 November to 31 December in the year 2000. The study location was the Amundsen Scott Station in Antarctica. ISCAT 2000 defines the second phase of a program designed to explore tropospheric chemistry in Antarctica. As in 1998, the 2000 ISCAT study revealed a strong oxidizing environment at South Pole (SP). During the 2000 investigation, however, the suite of measurements was greatly expanded. These new measurements established the recycling of reactive nitrogen as a critical component of this unique environment. This paper first presents the historical background leading up to the ISCAT 2000 observations; then it focuses on providing a summary of the year 2000 results and contrasts these with those recorded during 1998. Important developments made during the 2000 study included the recording of SP data for several species being emitted from the snowpack. These included NO, H 2O2 and CH2O. In this context, eddy-diffusion flux measurements provided the first quantitative estimates of the SP NO and NOx snow-to-atmosphere fluxes. This study also revealed that HNO 3 and HO2NO2 were major sink species for HOx and NOx radicals. And, it identified the critical factors responsible for SP NO levels exceeding those at other polar sites by nearly an order of magnitude. Finally, it reports on the levels of gas phase sulfur species and provides evidence indicating that the absence of DMS at SP is most likely due to its greatly shorten chemical lifetime in the near vicinity of the plateau. It is proposed that this is due to the influence of NO on the distribution of OH in the lower free troposphere over a region that extends well beyond the plateau itself. Details related to each of the above findings plus others can be found in the 11 accompanying Special Issue papers. © 2004 Elsevier Ltd. All rights reserved
The energy budget in Rayleigh-Benard convection
It is shown using three series of Rayleigh number simulations of varying
aspect ratio AR and Prandtl number Pr that the normalized dissipation at the
wall, while significantly greater than 1, approaches a constant dependent upon
AR and Pr. It is also found that the peak velocity, not the mean square
velocity, obeys the experimental scaling of Ra^{0.5}. The scaling of the mean
square velocity is closer to Ra^{0.46}, which is shown to be consistent with
experimental measurements and the numerical results for the scaling of Nu and
the temperature if there are strong correlations between the velocity and
temperature.Comment: 5 pages, 3 figures, new version 13 Mar, 200
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