Alfalfa Varieties for Ohio

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Psychopathic Personality as a Moderator of the Relationship Between Atypical Sexuality and Sexual Coercion Proclivity in the General Population

Being sexually coerced can have long-lasting psychological impacts on victims; with perpetration strongly predicted by elevated psychopathic traits. Owing to recent legislative developments in the United Kingdom that criminalize coercive control under the Domestic Abuse Act (2021), this study offers a timely investigation into the mechanisms of sexual coercion in domestic abuse across sexual abuse and coercive control. We used moderation analysis (n = 405) to investigate whether sexual coercion proclivity was predicted by facets of atypical sexuality (non-clinical elevated levels of sex drive, sexual sadism, and sexual masochism), and whether this relationship was moderated by psychopathic personality traits specifically the factor one components, which encompasses interpersonal and affective characteristics). Psychopathic personality traits significantly moderated the positive association between sex drive and sexual coercion proclivity, and between sexual sadism and sexual coercion proclivity in males (but not females), but psychopathic personality traits had no such moderating effect in the sexual masochism model. Results are discussed in terms of identifying risk factors of sexual coercion within a general population sample and international application. Open data and a preprint of this paper are available at [https://osf.io/xkcah/?view_only=134ff9c93ad24ba286515b348ce79c0c]

Positive airway pressure ventilation and complications in pediatric tracheocutaneous fistula repair

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152684/1/lary27834_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/152684/2/lary27834.pd

The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development.

Schistosomiasis affects millions of people in developing countries and is responsible for more than 200,000 deaths annually. Because of toxicity and limited spectrum of activity of alternatives, there is effectively only one drug, praziquantel, available for its treatment. Recent data suggest that drug resistance could soon be a problem. There is therefore the need to identify new drug targets and develop drugs for the treatment of schistosomiasis. Analysis of the Schistosoma mansoni genome sequence for proteins involved in detoxification processes found that it encodes a single cytochrome P450 (CYP450) gene. Here we report that the 1452 bp open reading frame has a characteristic heme-binding region in its catalytic domain with a conserved heme ligating cysteine, a hydrophobic leader sequence present as the membrane interacting region, and overall structural conservation. The highest sequence identity to human CYP450s is 22%. Double stranded RNA (dsRNA) silencing of S. mansoni (Sm)CYP450 in schistosomula results in worm death. Treating larval or adult worms with antifungal azole CYP450 inhibitors results in worm death at low micromolar concentrations. In addition, combinations of SmCYP450-specific dsRNA and miconazole show additive schistosomicidal effects supporting the hypothesis that SmCYP450 is the target of miconazole. Treatment of developing S. mansoni eggs with miconazole results in a dose dependent arrest in embryonic development. Our results indicate that SmCYP450 is essential for worm survival and egg development and validates it as a novel drug target. Preliminary structure-activity relationship suggests that the 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol moiety of miconazole is necessary for activity and that miconazole activity and selectivity could be improved by rational drug design

Working Toward a Post-Adoptive Model (PAM): Initial Steps for a Meta-Analysis of Post-Adoptive System Use

System use is a focal concept in information systems (IS) research in light of the fact that the benefits of information systems can only be realized when people use them after adoption. In the past decade, IS researchers have attempted to enhance the conceptualizations of system use from various perspectives. Nevertheless, our understanding of post-adoptive system use still remains at the early stage and scattered. In this research, we attempt to develop an initial post-adoptive model (PAM) based on early and preliminary steps toward a meta-analysis of the system use literature in the top IS journals. These initial steps give us a starting point for a full meta-analysis of this stream of research. Moving forward, we will conduct this analysis so as to develop a picture about the status quo of existing research on post-adoptive system use. Ultimately, our goals are to begin a synthesis of existing research models and point out directions for future research in the area of post-adoptive system use

The Wyoming Survey for H-alpha. I. Initial Results at z ~ 0.16 and 0.24

The Wyoming Survey for H-alpha, or WySH, is a large-area, ground-based, narrowband imaging survey for H-alpha-emitting galaxies over the latter half of the age of the Universe. The survey spans several square degrees in a set of fields of low Galactic cirrus emission. The observing program focuses on multiple dz~0.02 epochs from z~0.16 to z~0.81 down to a uniform (continuum+line) luminosity at each epoch of ~10^33 W uncorrected for extinction (3sigma for a 3" diameter aperture). First results are presented here for 98+208 galaxies observed over approximately 2 square degrees at redshifts z~0.16 and 0.24, including preliminary luminosity functions at these two epochs. These data clearly show an evolution with lookback time in the volume-averaged cosmic star formation rate. Integrals of Schechter fits to the extinction-corrected H-alpha luminosity functions indicate star formation rates per co-moving volume of 0.009 and 0.014 h_70 M_sun/yr/Mpc^3 at z~0.16 and 0.24, respectively. The formal uncertainties in the Schechter fits, based on this initial subset of the survey, correspond to uncertainties in the cosmic star formation rate density at the >~40% level; the tentative uncertainty due to cosmic variance is 25%, estimated from separately carrying out the analysis on data from the first two fields with substantial datasets.Comment: To appear in the Astronomical Journa

The emergence of international food safety standards and guidelines: understanding the current landscape through a historical approach

Following the Second World War, the Food and Agriculture Organization (FAO) and the World Health Organization (WHO) teamed up to construct an International Codex Alimentarius (or 'food code') which emerged in 1963. The Codex Committee on Food Hygiene (CCFH) was charged with the task of developing microbial hygiene standards, although it found itself embroiled in debate with the WHO over the nature these standards should take. The WHO was increasingly relying upon the input of biometricians and especially the International Commission on Microbial Specifications for Foods (ICMSF) which had developed statistical sampling plans for determining the microbial counts in the final end products. The CCFH, however, was initially more focused on a qualitative approach which looked at the entire food production system and developed codes of practice as well as more descriptive end-product specifications which the WHO argued were 'not scientifically correct'. Drawing upon historical archival material (correspondence and reports) from the WHO and FAO, this article examines this debate over microbial hygiene standards and suggests that there are many lessons from history which could shed light upon current debates and efforts in international food safety management systems and approaches

The extracellular polysaccharide Pel makes the attachment of P. aeruginosa to surfaces symmetric and short-ranged

Biofilms are surface-mounted, multicellular communities of microbes. Biofilms are often associated with chronic infections that resist treatment, evade the immune system, and damage host tissue. An essential characteristic of the biofilm state is that constituent organisms are bound in a polymeric matrix. This matrix gives the system spatial structure and clusters bacteria near each other, facilitating intercellular interactions. The Pseudomonas aeruginosa strain PAO1 is widely studied as a model biofilm-forming organism. The polymeric matrix of PAO1 biofilms is dominated by two bacteria-produced extracellular polymers, Pel and Psl. We use a combination of optical and atomic force microscopy to examine the roles of these polymers in very early biofilm development. In agreement with other researchers, we find that Psl mediates strong attachment to a glass surface. We find that Pel alone can mediate some attachment, but not as permanent as that mediated by Psl. Unexpectedly, we find that Pel promotes symmetric attachment, in the form of rod-shaped bacteria lying down flat on the surface, and that the presence of Pel makes attachment forces more short-ranged than they are with Psl alone. We suggest that these effects may result from synergistic interactions of Pel with the Psl polymeric matrix

Enriching the values of micro and small business research projects: co-creation service provision as perceived by academic, business and student

This is an Accepted Manuscript of an article published by Taylor & Francis in Studies in Higher Education, first published online 3 September 2014, available online: http://www.tandfonline.com/doi/full/10.1080/03075079.2014.942273.The National Committee of Inquiry into Higher Education (1996) chaired by Lord Dearing envisioned a university sector central to the UK’s knowledge-based economy. With successive government support the university-business partnership ideology has been put into practice. Widening participation has increased in emphasis over recent years, providing key innovations and skills to support business growth. Yet business schools activities in business growth is marginal against other university schools. The paper reports on an empirical study analyzing the university/business values derived from one small business engagement project. Data collected through semi-structured interviews, observations, memos, and discussions were coupled with critical evaluation of work and action-based learning (ABL) literature. Analysis reveals evidence of multiple value adding factors; it emerged that the existence of knowledge, present or generated through blended learning techniques, was a key value adding element. The findings enabled the construction of a universal process model providing a project framework, detailing areas of collaborative efforts and associated recompenses; this included ease in project advancements and a noticeably advanced project outcome. The study highlights these values in terms of individual and organizational learning, originality and quality of outputs. Given the growing importance of Small to Medium-sized Enterprises (SMEs) to the UK economy, understanding the value co-created by collaborative projects in delivering both work-based and ABL for graduates/students, academics and enterprise management is important.Peer reviewedFinal Accepted Versio