Universal Features in the Genome-level Evolution of Protein Domains

Protein domains are found on genomes with notable statistical distributions, which bear a high degree of similarity. Previous work has shown how these distributions can be accounted for by simple models, where the main ingredients are probabilities of duplication, innovation, and loss of domains. However, no one so far has addressed the issue that these distributions follow definite trends depending on protein-coding genome size only. We present a stochastic duplication/innovation model, falling in the class of so-called Chinese Restaurant Processes, able to explain this feature of the data. Using only two universal parameters, related to a minimal number of domains and to the relative weight of innovation to duplication, the model reproduces two important aspects: (a) the populations of domain classes (the sets, related to homology classes, containing realizations of the same domain in different proteins) follow common power-laws whose cutoff is dictated by genome size, and (b) the number of domain families is universal and markedly sublinear in genome size. An important ingredient of the model is that the innovation probability decreases with genome size. We propose the possibility to interpret this as a global constraint given by the cost of expanding an increasingly complex interactome. Finally, we introduce a variant of the model where the choice of a new domain relates to its occurrence in genomic data, and thus accounts for fold specificity. Both models have general quantitative agreement with data from hundreds of genomes, which indicates the coexistence of the well-known specificity of proteomes with robust self-organizing phenomena related to the basic evolutionary ``moves'' of duplication and innovation

Geometrically constrained magnetic wall

The structure and properties of a geometrically constrained magnetic wall in a constriction separating two wider regions are investigated theoretically. They are shown to differconsiderably from those of an unconstrained wall, so that the geometrically constrained magnetic wall truly constitutes a new kind of magnetic wall, besides the well known Bloch and Neel walls. In particular, the width of a constrained wall cann become very small if the characteristic length of the constriction is small, as is actually the case in an atomic point contact. This provides a simple, natural explanation for the large magnetoresistance observed in ferromagnetic atomic point contacts.Comment: RevTeX, 4 pages, 4 eps figures; v2: revised version; v3: ref. adde

Hole Expansion Simulations of TWIP Steel Sheet Sample

In this work, the stretch flangeability of a TWIP steel sheet sample was investigated both experimentally and numerically through the hole expansion test. Uniaxial tension and disk compression tests were performed to characterize the flow behavior and plastic anisotropy for the TWIP steel sheet sample. The punch load-stroke curve, hole diameter and specimen surface strain distribution near the hole was measured. Then finite element simulations of the hole expansion test were carried out using the finite element code ABAQUS with three yield criteria: von Mises, Hill 1948 and Yld2000-2d. The predicted and experimental results were compared in terms of the final hole radii and the strain distribution.open111Nsciescopu

High Kinetic Inductance Superconducting Nanowire Resonators for Circuit QED in a Magnetic Field

We present superconducting microwave-frequency resonators based on NbTiN nanowires. The small cross section of the nanowires minimizes vortex generation, making the resonators resilient to magnetic fields. Measured intrinsic quality factors exceed $2\times 10^5$ in a $6$ T in-plane magnetic field, and $3\times 10^4$ in a $350$ mT perpendicular magnetic field. Due to their high characteristic impedance, these resonators are expected to develop zero-point voltage fluctuations one order of magnitude larger than in standard coplanar waveguide resonators. These properties make the nanowire resonators well suited for circuit QED experiments needing strong coupling to quantum systems with small electric dipole moments and requiring a magnetic field, such as electrons in single and double quantum dots

Accurate evolutions of inspiralling and magnetized neutron-stars: equal-mass binaries

By performing new, long and numerically accurate general-relativistic simulations of magnetized, equal-mass neutron-star binaries, we investigate the role that realistic magnetic fields may have in the evolution of these systems. In particular, we study the evolution of the magnetic fields and show that they can influence the survival of the hypermassive-neutron star produced at the merger by accelerating its collapse to a black hole. We also provide evidence that even if purely poloidal initially, the magnetic fields produced in the tori surrounding the black hole have toroidal and poloidal components of equivalent strength. When estimating the possibility that magnetic fields could have an impact on the gravitational-wave signals emitted by these systems either during the inspiral or after the merger we conclude that for realistic magnetic-field strengths B<~1e12 G such effects could be detected, but only marginally, by detectors such as advanced LIGO or advanced Virgo. However, magnetically induced modifications could become detectable in the case of small-mass binaries and with the development of gravitational-wave detectors, such as the Einstein Telescope, with much higher sensitivities at frequencies larger than ~2 kHz.Comment: 18 pages, 10 figures. Added two new figures (figures 1 and 7). Small modifications to the text to match the version published on Phys. Rev.

Flavor SU(4) breaking between effective couplings

Using a framework in which all elements are constrained by Dyson-Schwinger equation studies in QCD, and therefore incorporates a consistent, direct and simultaneous description of light- and heavy-quarks and the states they constitute, we analyze the accuracy of SU(4)-flavor symmetry relations between {\pi}{\rho}{\pi}, K{\rho}K and D{\rho}D couplings. Such relations are widely used in phenomenological analyses of the interactions between matter and charmed mesons. We find that whilst SU(3)-flavor symmetry is accurate to 20%, SU(4) relations underestimate the D{\rho}D coupling by a factor of five.Comment: 5 pages, two figure