5,949 research outputs found
A comparison of head and manual control for a position-control pursuit tracking task
Head control was compared with manual control in a pursuit tracking task involving proportional controlled-element dynamics. An integrated control/display system was used to explore tracking effectiveness in horizontal and vertical axes tracked singly and concurrently. Compared with manual tracking, head tracking resulted in a 50 percent greater rms error score, lower pilot gain, greater high-frequency phase lag and greater low-frequency remnant. These differences were statistically significant, but differences between horizontal- and vertical-axis tracking and between 1- and 2-axis tracking were generally small and not highly significant. Manual tracking results were matched with the optimal control model using pilot-related parameters typical of those found in previous manual control studies. Head tracking performance was predicted with good accuracy using the manual tracking model plus a model for head/neck response dynamics obtained from the literature
The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with G alpha(12/13) and RhoA
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In vivo evaluation of edge-loading in metal-on-metal hip resurfacing patients with pseudotumours
Objectives: Pseudotumours (abnormal peri-prosthetic soft-tissue reactions) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) have been associated with elevated metal ion levels, suggesting that excessive wear may occur due to edge-loading of these MoM implants. This study aimed to quantify in vivo edge-loading in MoMHRA patients with and without pseudotumours during functional activities. Methods: The duration and magnitude of edge-loading in vivo was quantified during functional activities by combining the dynamic hip joint segment contact force calculated from the three-dimensional (3D) motion analysis system with the 3D reconstruction of orientation of the acetabular component and each patient’s specific hip joint centre, based on CT scans. Results: Edge-loading in the hips with pseudotumours occurred with a four-fold increase in duration and magnitude of force compared with the hips without pseudotumours (p = 0.02). Conclusions: The study provides the first in vivo evidence to support that edge-loading is an important mechanism that leads to localised excessive wear (edge-wear), with subsequent elevation of metal ion levels in MoMHRA patients with pseudotumours
The Low- and Intermediate-Mass Stellar Population in the Small Magellanic Cloud: The Central Stars of Planetary Nebulae
We present a study on the central stars (CSs) of Planetary Nebulae (PNe)
observed in the Small Magellanic Cloud (SMC) with the Space Telescope Imaging
Spectrograph instrument on-board the HST. The stellar magnitudes have been
measured using broad-band photometry, and Zanstra analysis of the nebulae
provided the stellar temperatures. From the location of the CSs on the HR
diagram, and by comparing the observed CSs with current models of stellar
evolution, we infer the CSs masses. We examine closely the possibility of light
contamination in the bandpass from an unrecognized stellar companion, and we
establish strong constraints on the existence and nature of any binary
companion. We find an average mass of 0.63 Msun, which is similar to the mass
obtained for a sample of CSs in the LMC (0.65 Msun). However, the SMC and LMC
CS mass distributions differ slightly, the SMC sample lacking an
intermediate-mass stellar population (0.65 to 0.75 Msun). We discuss the
significance and possible reasons for the difference between the two mass
distributions. In particular, we consider the differences in the star formation
history between the clouds and the mass-loss rate dependence on metallicity.Comment: 30 pages, 6 figures, 5 tables. To be published in ApJ (October 20
Modelling the regulation of immunoglobulin class switching to IgE and IgG in human B cells to reduce animal use
Weighted network modules
The inclusion of link weights into the analysis of network properties allows
a deeper insight into the (often overlapping) modular structure of real-world
webs. We introduce a clustering algorithm (CPMw, Clique Percolation Method with
weights) for weighted networks based on the concept of percolating k-cliques
with high enough intensity. The algorithm allows overlaps between the modules.
First, we give detailed analytical and numerical results about the critical
point of weighted k-clique percolation on (weighted) Erdos-Renyi graphs. Then,
for a scientist collaboration web and a stock correlation graph we compute
three-link weight correlations and with the CPMw the weighted modules. After
reshuffling link weights in both networks and computing the same quantities for
the randomised control graphs as well, we show that groups of 3 or more strong
links prefer to cluster together in both original graphs.Comment: 19 pages, 7 figure
\u3ci\u3eMedicine Meets Virtual Reality 17\u3c/i\u3e
Chapter, A Virtual Reality Training Program for Improvement of Robotic Surgical Skills, co-authored by Mukul Mukherjee and Nicholas Stergiou, UNO faculty members.
Chapter, Consistency of Performance of Robot-Assisted Surgical Tasks in Virtual Reality, co-authored by Mukul Mukherjee and Nicholas Stergiou, UNO faculty members.
The 17th annual Medicine Meets Virtual Reality (MMVR17) was held January 19-22, 2009, in Long Beach, CA, USA. The conference is well established as a forum for emerging data-centered technologies for medical care and education. Each year, it brings together an international community of computer scientists and engineers, physicians and surgeons, medical educators and students, military medicine specialists and biomedical futurists. MMVR emphasizes inter-disciplinary collaboration in the development of more efficient and effective physician training and patient care. The MMVR17 proceedings collect 108 papers by conference lecture and poster presenters. These papers cover recent developments in biomedical simulation and modeling, visualization and data fusion, haptics, robotics, sensors and other related information-based technologies. Key applications include medical education and surgical training, clinical diagnosis and therapy, physical rehabilitation, psychological assessment, telemedicine and more. From initial vision and prototypes, through assessment and validation, to clinical and academic utilization and commercialization - MMVR explores the state-of-the-art and looks toward healthcare’s future. The proceedings volume will interest physicians, surgeons and other medical professionals interested in emerging and future tools for diagnosis and therapy; educators responsible for training the next generation of doctors and scientists; IT and medical device engineers creating state-of-the-art and next-generation simulation, imaging, robotics and communication systems; data technologists creating systems for gathering, processing and distributing medical intelligence; military medicine specialists addressing the challenges of warfare and defense health needs; and biomedical futurists and investors who want to understand where the field is headed.https://digitalcommons.unomaha.edu/facultybooks/1233/thumbnail.jp
Central Stars of Planetary Nebulae in the Large Magellanic Cloud: A Far-UV Spectroscopic Analysis
We observed seven central stars of planetary nebulae (CSPN) in the Large
Magellanic Cloud (LMC) with the Far Ultraviolet Spectroscopic Explorer (FUSE),
and performed a model-based analysis of these spectra in conjunction with
Hubble Space Telescope (HST) spectra in the UV and optical range to determine
the stellar and nebular parameters. Most of the objects show wind features, and
they have effective temperatures ranging from 38 to 60 kK with mass-loss rates
of ~= 5x10^-8 Msun/yr. Five of the objects have typical LMC abundances. One
object (SMP LMC 61) is a [WC4] star, and we fit its spectra with He/C/O-rich
abundances typical of the [WC] class, and find its atmosphere to be
iron-deficient. Most objects have very hot (T ~> 2000 K) molecular hydrogen in
their nebulae, which may indicate a shocked environment. One of these (SMP LMC
62) also displays OVI 1032-38 nebular emission lines, rarely observed in PN.Comment: 53 pages, 15 figures (11 color). Accepted for publication in Ap
Neon and Sulfur Abundances of Planetary Nebulae in the Magellanic Clouds
The chemical abundances of neon and sulfur for 25 planetary nebulae (PNe) in
the Magellanic Clouds are presented. These abundances have been derived using
mainly infrared data from the Spitzer Space Telescope. The implications for the
chemical evolution of these elements are discussed. A comparison with similarly
obtained abundances of Galactic PNe and HII regions and Magellanic Clouds HII
regions is also given. The average neon abundances are 6.0x10(-5) and
2.7x10(-5) for the PNe in the Large and Small Magellanic Clouds respectively.
These are ~1/3 and 1/6 of the average abundances of Galactic planetary nebulae
to which we compare. The average sulfur abundances for the LMC and SMC are
respectively 2.7x10(-6) and 1.0x10(-6). The Ne/S ratio (23.5) is on average
higher than the ratio found in Galactic PNe (16) but the range of values in
both data sets is similar for most of the objects. The neon abundances found in
PNe and HII regions agree with each other. It is possible that a few (3-4) of
the PNe in the sample have experienced some neon enrichment, but for two of
these objects the high Ne/S ratio can be explained by their very low sulfur
abundances. The neon and sulfur abundances derived in this paper are also
compared to previously published abundances using optical data and
photo-ionization models.Comment: 13 pages, 4 tables, 5 figures. Accepted for publication in Ap
Identifying dynamical modules from genetic regulatory systems: applications to the segment polarity network
BACKGROUND
It is widely accepted that genetic regulatory systems are 'modular', in that the whole system is made up of smaller 'subsystems' corresponding to specific biological functions. Most attempts to identify modules in genetic regulatory systems have relied on the topology of the underlying network. However, it is the temporal activity (dynamics) of genes and proteins that corresponds to biological functions, and hence it is dynamics that we focus on here for identifying subsystems.
RESULTS
Using Boolean network models as an exemplar, we present a new technique to identify subsystems, based on their dynamical properties. The main part of the method depends only on the stable dynamics (attractors) of the system, thus requiring no prior knowledge of the underlying network. However, knowledge of the logical relationships between the network components can be used to describe how each subsystem is regulated. To demonstrate its applicability to genetic regulatory systems, we apply the method to a model of the Drosophila segment polarity network, providing a detailed breakdown of the system.
CONCLUSION
We have designed a technique for decomposing any set of discrete-state, discrete-time attractors into subsystems. Having a suitable mathematical model also allows us to describe how each subsystem is regulated and how robust each subsystem is against perturbations. However, since the subsystems are found directly from the attractors, a mathematical model or underlying network topology is not necessarily required to identify them, potentially allowing the method to be applied directly to experimental expression data
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