865 research outputs found
A study of the excreted porphyrins in human porphyria : with particular reference to the isolation and identification of the porphyrinpeptide complexes.
The largest white light flare ever observed: 25 April 1984, 0001 UT
The X13/3B flare of 25 April 1984, 0001 UT, was accompanied by intense white light emission that reached a peak power output approx 2x10 to the 29 erg/sec in the optical/near UV continuum; the total energy radiated in the continuum alone reached 10 to the 32 power ergs. This was the most powerful white light flare yet recorded, exceeding the peak output of the largest previously known event by more than one order of magnitude. The flare was a two-ribbon type with intense embedded kernels as observed in both Balmer-alpha line and Balmer continuum, and each of these flare ribbons covered separate umbrae shortly after the maximum of the event. The onset and peak of the white light emission coincided with the onset and peak of the associated E greater than 100 KeV hard X-ray burst, while the 1-8 angstrom soft X-ray emission reached its maximum 4 minutes after the peak in white light
Kerncraft: A Tool for Analytic Performance Modeling of Loop Kernels
Achieving optimal program performance requires deep insight into the
interaction between hardware and software. For software developers without an
in-depth background in computer architecture, understanding and fully utilizing
modern architectures is close to impossible. Analytic loop performance modeling
is a useful way to understand the relevant bottlenecks of code execution based
on simple machine models. The Roofline Model and the Execution-Cache-Memory
(ECM) model are proven approaches to performance modeling of loop nests. In
comparison to the Roofline model, the ECM model can also describes the
single-core performance and saturation behavior on a multicore chip. We give an
introduction to the Roofline and ECM models, and to stencil performance
modeling using layer conditions (LC). We then present Kerncraft, a tool that
can automatically construct Roofline and ECM models for loop nests by
performing the required code, data transfer, and LC analysis. The layer
condition analysis allows to predict optimal spatial blocking factors for loop
nests. Together with the models it enables an ab-initio estimate of the
potential benefits of loop blocking optimizations and of useful block sizes. In
cases where LC analysis is not easily possible, Kerncraft supports a cache
simulator as a fallback option. Using a 25-point long-range stencil we
demonstrate the usefulness and predictive power of the Kerncraft tool.Comment: 22 pages, 5 figure
Empirical ground-motion prediction equations for Northwestern Turkey using the aftershocks of the 1999 Kocaeli earthquake
We present ground motion models for northwestern
Turkey using the aftershocks of the Mw 7.4, 1999
Kocaeli earthquake. We consider 4047 velocity and
acceleration records for each component of motion,
from 528 earthquakes recorded by stations belonging to
regional networks. The ground motion models obtained
provide peak ground velocity, peak ground acceleration, and
spectral accelerations for 8 different frequencies between
1 and 10 Hz. The analysis of the error distribution shows
that the record-to-record component of variance is the
largest contribution to the standard deviation of the
calibrated ground- motion models. Furthermore, a clear
dependence of inter-event error on stress drop is observed.
The empirical ground-motion prediction equations, derived
for both the larger horizontal and vertical components, are
valid in the local magnitude range from 0.5 to 5.9, and for
hypocentral distances up to 190 km. Citation: Bindi, D.,
S. Parolai, H. Grosser, C. Milkereit, and E. Durukal (2007),
Empirical ground-motion prediction equations for northwestern
Turkey using the aftershocks of the 1999 Kocaeli earthquake
Source parameters and seismic moment-magnitude scaling for Northwestern Turkey
Abstract The source parameters of 523 aftershocks (0.5 ML 5.9) of the 1999
Kocaeli earthquake are determined by performing a two-step spectral fitting procedure.
The source spectrum, corrected for both site and propagation effects, is described
in terms of a standard x-square model multiplied by an exponential term of
frequency. The latter term is introduced to estimate the high-frequency (f 12 Hz)
fall-off of the acceleration source spectra by computing the j parameter. The seismic
moments obtained range between 1.05 1014 and 2.41 1017 N m, whereas the
Brune stress drops are between 0.002 and 40 MPa. The j value varies between 0.00
and 0.08 sec, indicating a decay of the acceleration level at the higher frequency
part of the spectrum greater than that assumed by the x 2 model. Both the stress
drop and the j parameter show the tendency of increasing with aftershock magnitude.
No evidence of self-similarity breakdown is observed between the source radius and
M0. Finally, both the seismic moment and the moment magnitude are compared with
the local magnitude to derive new moment–magnitude relationships for the area
Parvalbumin interneurons are differentially connected to principal cells in inhibitory feedback microcircuits along the dorso-ventral axis of the medial entorhinal cortex
The medial entorhinal cortex (mEC) shows a high degree of spatial tuning, predominantly grid cell activity, which is reliant on robust, dynamic inhibition provided by local interneurons (INs). In fact, feedback inhibitory microcircuits involving fast-spiking parvalbumin (PV) basket cells (BCs) are believed to contribute dominantly to the emergence of grid cell firing in principal cells (PrCs). However, the strength of PV BC-mediated inhibition onto PrCs is not uniform in this region, but high in the dorsal and weak in the ventral mEC. This is in good correlation with divergent grid field sizes, but the underlying morphologic and physiological mechanisms remain unknown. In this study, we examined PV BCs in layer (L)2/3 of the mEC characterizing their intrinsic physiology, morphology and synaptic connectivity in the juvenile rat. We show that while intrinsic physiology and morphology are broadly similar over the dorsoventral axis, PV BCs form more connections onto local PrCs in the dorsal mEC, independent of target cell type. In turn, the major PrC subtypes, pyramidal cell (PC) and stellate cell (SC), form connections onto PV BCs with lower, but equal probability. These data thus identify inhibitory connectivity as source of the gradient of inhibition, plausibly explaining divergent grid field formation along this dorsoventral axis of the mEC
On the Geroch-Traschen class of metrics
We compare two approaches to semi-Riemannian metrics of low regularity. The maximally 'reasonable' distributional setting of Geroch and Traschen is shown to be consistently contained in the more general setting of nonlinear distributional geometry in the sense of Colombea
Search for a Solution of the Pioneer Anomaly
In 1972 and 1973 the Pioneer 10 and 11 missions were launched. They were the
first to explore the outer solar system and achieved stunning breakthroughs in
deep-space exploration. But beginning in about 1980 an unmodeled force of \sim
8 \times 10^{-8} cm/s^2, directed approximately towards the Sun, appeared in
the tracking data. It later was unambiguously verified as being in the data and
not an artifact. The cause remains unknown (although radiant heat remains a
likely origin). With time more and more effort has gone into understanding this
anomaly (and also possibly related effects). We review the situation and
describe ongoing programs to resolve the issue.Comment: 24 pages 8 figure
Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics
The COVID-19 pandemic constitutes an ongoing worldwide threat to human society and has caused massive impacts on global public health, the economy and the political landscape. The key to gaining control of the disease lies in understanding the genetics of SARS-CoV-2 and the disease spectrum that follows infection. This study leverages traditional and intelligent bibliometric methods to conduct a multi-dimensional analysis on 5,632 COVID-19 genetic research papers, revealing that 1) the key players include research institutions from the United States, China, Britain and Canada; 2) research topics predominantly focus on virus infection mechanisms, virus testing, gene expression related to the immune reactions and patient clinical manifestation; 3) studies originated from the comparison of SARS-CoV-2 to previous human coronaviruses, following which research directions diverge into the analysis of virus molecular structure and genetics, the human immune response, vaccine development and gene expression related to immune responses; and 4) genes that are frequently highlighted include ACE2, IL6, TMPRSS2, and TNF. Emerging genes to the COVID-19 consist of FURIN, CXCL10, OAS1, OAS2, OAS3, and ISG15. This study demonstrates that our suite of novel bibliometric tools could help biomedical researchers follow this rapidly growing field and provide substantial evidence for policymakers' decision-making on science policy and public health administration
ML scale in Northwestern Turkey from 1999 Izmit aftershock: updates
Abstract We present an update of the local magnitude scale previously calibrated
for northwestern Turkey by Baumbach et al. (2003). The path coverage in the westernmost
part of the analyzed area has been increased, as well as the number of
amplitudes for distance greater than 110 km. Furthermore, a set of recordings from
accelerometric stations operated by the Kandilli Observatory and Earthquake Research
Institute (KOERI) has been merged with the recordings by the Sapanca-Bolu
and German Task Force seismological networks. In all, 4047 recordings from
528 earthquakes recorded by 31 seismometers and 23 accelerometers are considered
to calibrate the local magnitude scale over a hypocentral distance range from 10
to 190 km. By analyzing the unit covariance matrix and the resolution matrix, we
show how the source-to-station geometries of the seismic and strong-motion networks
affect the uncertainties of the computed station corrections, attenuation coefficients,
and magnitudes. The assumptions made concerning the reference station
correction, and the change in the amplification for the Wood–Anderson torsion seismograph
from 2800 to 2080 (Uhrhammer and Collins, 1990) introduced an offset of
about 0.34 in the magnitudes with respect to Baumbach et al. (2003), with the updated
local magnitude scale ranges from 0.50 to 5.91. The distribution of the residuals with
distance confirms that the extension of both the magnitude and distance ranges and
the improved path coverage have preserved the high quality that characterized the
data set analyzed by Baumbach et al. (2003)
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