570 research outputs found

    Playing with fermion couplings in Higgsless models

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    We discuss the fermion couplings in a four dimensional SU(2) linear moose model by allowing for direct couplings between the left-handed fermions on the boundary and the gauge fields in the internal sites. This is realized by means of a product of non linear σ\sigma-model scalar fields which, in the continuum limit, is equivalent to a Wilson line. The effect of these new non local couplings is a contribution to the ϵ3\epsilon_3 parameter which can be of opposite sign with respect to the one coming from the gauge fields along the string. Therefore, with some fine tuning, it is possible to satisfy the constraints from the electroweak data.Comment: Latex file, 20 pages, 4 eps figure

    The finite index basis property

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    We describe in this paper a connection between bifix codes, symbolic dynamical systems and free groups. This is in the spirit of the connection established previously for the symbolic systems corresponding to Sturmian words. We introduce a class of sets of factors of an infinite word with linear factor complexity containing Sturmian sets and regular interval exchange sets, namely the class of tree sets. We prove as a main result that for a uniformly recurrent tree set S, a finite bifix code X on the alphabet A is S-maximal of S-degree d if and only if it is the basis of a subgroup of index d of the free group on

    Glutamine-Derived Aspartate Biosynthesis in Cancer Cells: Role of Mitochondrial Transporters and New Therapeutic Perspectives

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    Aspartate has a central role in cancer cell metabolism. Aspartate cytosolic availability is crucial for protein and nucleotide biosynthesis as well as for redox homeostasis. Since tumor cells display poor aspartate uptake from the external environment, most of the cellular pool of aspar-tate derives from mitochondrial catabolism of glutamine. At least four transporters are involved in this metabolic pathway: the glutamine (SLC1A5_var), the aspartate/glutamate (AGC), the as-partate/phosphate (uncoupling protein 2, UCP2), and the glutamate (GC) carriers, the last three belonging to the mitochondrial carrier family (MCF). The loss of one of these transporters causes a paucity of cytosolic aspartate and an arrest of cell proliferation in many different cancer types. The aim of this review is to clarify why different cancers have varying dependencies on metabolite transporters to support cytosolic glutamine-derived aspartate availability. Dissecting the precise metabolic routes that glutamine undergoes in specific tumor types is of upmost importance as it promises to unveil the best metabolic target for therapeutic intervention

    Optical coherence tomography angiography findings in Huntington’s disease

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    Objectives: To evaluate the retinal and choriocapillaris vascular networks in macular region and the central choroidal thickness (CCT) in patients affected by Huntington disease (HD), using optical coherence tomography angiography (OCTA) and enhanced depth imaging spectral-domain OCT (EDI SD-OCT). Methods: We assessed the vessel density (VD) in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using OCTA, while CCT was measured by EDI SD-OCT. Results: Sixteen HD patients (32 eyes) and thirteen healthy controls (26 eyes) were enrolled in this prospective study. No significant difference in retinal and choriocapillaris VD was found between HD patients and controls while CCT turned to be thinner in patients respect to controls. There were no significant relationships between OCTA findings and neurological parameters. Conclusion: The changes in choroidal structure provide useful information regarding the possible neurovascular involvement in the physiopathology of HD. Choroidal vascular network could be a useful parameter to evaluate the vascular impairment that occurs in this neurodegenerative disease

    Behavior and Strengthening of RC Beam-Column Joints: Experimental Program and First Results of the Research Activity in the Framework of DPC-ReLUIS Project (Research Line 2)

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    The 2005-2008 DPC-Reluis Project, funded by the Italian Department of Civil Protection (DPC), is made up of ten Research Lines (RL). RL 2 specifically focuses on the seismic performance of existing RC buildings and is, in turn, organised in nine different Tasks. In the paper, the design of the research activities being carried out within the Task 7 by the four involved Research Units (RU UNIBAS, RU UNIUD, RU UNISA, and RU UNINA) and some first results are reported. Main objective of Task 7 is to investigate on the experimental behaviour of beam-column joints without or with strengthening, thus providing a contribution to a more reliable evaluation of the seismic vulnerability of Reinforced Concrete existing buildings. To this purpose the main activities carried out have been devoted to design and set up of wide experimental programs on beam-column joints relevant to typical existing RC buildings having different Earthquake Resistant Design (ERD) level, to make a literature review of the state of the art on the subject, to perform numerical simulations based on some analytical models available in literature in order to fully understand the mechanical behaviour. Further, some results of the tests already carried out are reported, analysed and compared in order to understand the failure mechanism and evaluate the seismic performance of joints with and without ERD

    Life satisfaction during temporary housing after an earthquake: Comparing three cases in Italy

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    A disaster has a considerable impact on people who have lost their homes. We analyzed the life satisfaction of displaced people accommodated in temporary housing after three strong earthquakes that occurred in Italy in 2009 (Abruzzo), 2012 (Emilia), and 2016–17 (Central Italy). Information was obtained through an anonymous survey on a large number of variables related to socio-demographic features, temporary housing type and quality, social support and protection network, personal psychological resources and preparedness, and psychophysical health. Responses were collected through face-to-face and telephone interviews, stand-alone paper-and-pencil questionnaires, or online (N = 261). In the whole-sample analysis, the significant predictors of life satisfaction were earthquake preparedness, which earthquake out of three was experienced, protection network, accommodation type and quality, and general health status, thus highlighting the complex and multi-faceted nature of the underpinnings of life satisfaction in people displaced after an earthquake. However, different predictors explained life satisfaction in the analysis of each earthquake, pointing to the need to consider their specificity and the local context. Nevertheless, the perceived quality of the accommodation was a significant predictor both in the whole-sample analysis and in the analysis of two earthquakes (2009 Abruzzo and 2012 Emilia), highlighting the importance of providing temporary houses with appropriate properties (privacy, space, thermal and acoustic insulation, light, quality of materials, surroundings) and placed in locations that allow the resumption of life activities (e.g., education, work, socialization, health and public facilities and services)

    Experimental study for evaluation of a suitable ground displacement monitoring system: Pilot hole Campi Flegrei Deep Drilling Project case

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    The paper presents an experimental study carried out in 2012 during the drilling activity for a pilot hole performed in the framework of the Campi Flegrei Deep Drilling Project. A monitoring network has been installed to test and choose a suitable ground deformation system for the subsequent deep drilling of about 3.5 km in the Campi Flegrei Caldera (Italy). We describe the seismic network installed to characterize the structure of the pilot hole area and the ground deformation monitoring system chosen for the small drilling area. Data analysis and results obtained indicate that Total Station is a suitable tool for this case.Published4V. Dinamica dei processi pre-eruttiviN/A or not JC

    LIPSS applied to wide bandgap semiconductors and dielectrics: assessment and future perspectives

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    With the aim of presenting the processes governing the Laser-Induced Periodic Surface Structures (LIPSS), its main theoretical models have been reported. More emphasis is given to those suitable for clarifying the experimental structures observed on the surface of wide bandgap semiconductors (WBS) and dielectric materials. The role played by radiation surface electromagnetic waves as well as Surface Plasmon Polaritons in determining both Low and High Spatial Frequency LIPSS is briefly discussed, together with some experimental evidence. Non-conventional techniques for LIPSS formation are concisely introduced to point out the high technical possibility of enhancing the homogeneity of surface structures as well as tuning the electronic properties driven by point defects induced in WBS. Among these, double-or multiple-fs-pulse irradiations are shown to be suitable for providing further insight into the LIPSS process together with fine control on the formed surface structures. Modifications occurring by LIPSS on surfaces of WBS and dielectrics display high potentialities for their cross-cutting technological features and wide applications in which the main surface and electronic properties can be engineered. By these assessments, the employment of such nanostructured materials in innovative devices could be envisaged
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