Analytical computation of the off-axis Effective Area of grazing incidence X-ray mirrors

Focusing mirrors for X-ray telescopes in grazing incidence, introduced in the 70s, are characterized in terms of their performance by their imaging quality and effective area, which in turn determines their sensitivity. Even though the on-axis effective area is assumed in general to characterize the collecting power of an X-ray optic, the telescope capability of imaging extended X-ray sources is also determined by the variation in its effective area with the off-axis angle. [...] The complex task of designing optics for future X-ray telescopes entails detailed computations of both imaging quality and effective area on- and off-axis. Because of their apparent complexity, both aspects have been, so far, treated by using ray-tracing routines aimed at simulating the interaction of X-ray photons with the reflecting surfaces of a given focusing system. Although this approach has been widely exploited and proven to be effective, it would also be attractive to regard the same problem from an analytical viewpoint, to assess an optical design of an X-ray optical module with a simpler calculation than a ray-tracing routine. [...] We have developed useful analytical formulae for the off-axis effective area of a double-reflection mirror in the double cone approximation, requiring only an integration and the standard routines to calculate the X-ray coating reflectivity for a given incidence angle. [...] Algebraic expressions are provided for the mirror geometric area, as a function of the off-axis angle. Finally, the results of the analytical computations presented here are validated by comparison with the corresponding predictions of a ray-tracing code.Comment: 12 pages, 11 figures, accepted for publication in "Astronomy & Astrophysics", section "Instruments, observational techniques, and data processing". Updated version after grammatical revision and typos correctio

Simbol-X Hard X-ray Focusing Mirrors: Results Obtained During the Phase A Study

Simbol-X will push grazing incidence imaging up to 80 keV, providing a strong improvement both in sensitivity and angular resolution compared to all instruments that have operated so far above 10 keV. The superb hard X-ray imaging capability will be guaranteed by a mirror module of 100 electroformed Nickel shells with a multilayer reflecting coating. Here we will describe the technogical development and solutions adopted for the fabrication of the mirror module, that must guarantee an Half Energy Width (HEW) better than 20 arcsec from 0.5 up to 30 keV and a goal of 40 arcsec at 60 keV. During the phase A, terminated at the end of 2008, we have developed three engineering models with two, two and three shells, respectively. The most critical aspects in the development of the Simbol-X mirrors are i) the production of the 100 mandrels with very good surface quality within the timeline of the mission; ii) the replication of shells that must be very thin (a factor of 2 thinner than those of XMM-Newton) and still have very good image quality up to 80 keV; iii) the development of an integration process that allows us to integrate these very thin mirrors maintaining their intrinsic good image quality. The Phase A study has shown that we can fabricate the mandrels with the needed quality and that we have developed a valid integration process. The shells that we have produced so far have a quite good image quality, e.g. HEW <~30 arcsec at 30 keV, and effective area. However, we still need to make some improvements to reach the requirements. We will briefly present these results and discuss the possible improvements that we will investigate during phase B.Comment: 6 pages, 3 figures, invited talk at the conference "2nd International Simbol-X Symposium", Paris, 2-5 december, 200

Unexpected frequency of genomic alterations in histologically normal colonic tissue from colon cancer patients

As shown by genomic studies, colorectal cancer (CRC) is a highly heterogeneous disease, where copy number alterations (CNAs) may greatly vary among different patients. To explore whether CNAs may be present also in histologically normal tissues from patients affected by CRC, we performed CGH + SNP Microarray on 15 paired tumoral and normal samples. Here, we report for the first time the occurrence of CNAs as a common feature of the histologically normal tissue from CRC patients, particularly CNAs affecting different oncogenes and tumor-suppressor genes, including some not previously reported in CRC and others known as being involved in tumor progression. Moreover, from the comparison of normal vs paired tumoral tissue, we were able to identify three groups: samples with an increased number of CNAs in tumoral vs normal tissue, samples with a similar number of CNAs in both tissues, and samples with a decrease of CNAs in tumoral vs normal tissue, which may be likely due to a selection of the cell population within the tumor. In conclusion, our approach allowed us to uncover for the first time an unexpected frequency of genetic alteration in normal tissue, suggesting that tumorigenic genetic lesions are already present in histologically normal colonic tissue and that the use in array comparative genomic hybridization (CGH) studies of normal samples as reference for the paired tumors can lead to misrepresented genomic data, which may be incomplete or limited, especially if used for the research of target molecules for personalized therapy and for the possible correlation with clinical outcome

FAVOR (FAst Variability Optical Registration) -- A Two-telescope Complex for Detection and Investigation of Short Optical Transients

An astronomical complex intended to detect optical transients (OTs) in a wide field and follow them up with high time resolution investigation is described.Comment: 4 pages, 3 figures. To be published in "Il Nuovo Cimento", Proceedings of the 4th Rome Workshop on Gamma-Ray Bursts in the Afterglow Era, eds. L. Piro, L. Amati, S. Covino, B. Gendr

Mirrors for X-ray telescopes: Fresnel diffraction-based computation of point spread functions from metrology

The imaging sharpness of an X-ray telescope is chiefly determined by the optical quality of its focusing optics, which in turn mostly depends on the shape accuracy and the surface finishing of the grazing-incidence X-ray mirrors that compose the optical modules. To ensure the imaging performance during the mirror manufacturing, a fundamental step is predicting the mirror point spread function (PSF) from the metrology of its surface. Traditionally, the PSF computation in X-rays is assumed to be different depending on whether the surface defects are classified as figure errors or roughness. [...] The aim of this work is to overcome this limit by providing analytical formulae that are valid at any light wavelength, for computing the PSF of an X-ray mirror shell from the measured longitudinal profiles and the roughness power spectral density (PSD), without distinguishing spectral ranges with different treatments. The method we adopted is based on the Huygens-Fresnel principle for computing the diffracted intensity from measured or modeled profiles. In particular, we have simplified the computation of the surface integral to only one dimension, owing to the grazing incidence that reduces the influence of the azimuthal errors by orders of magnitude. The method can be extended to optical systems with an arbitrary number of reflections - in particular the Wolter-I, which is frequently used in X-ray astronomy - and can be used in both near- and far-field approximation. Finally, it accounts simultaneously for profile, roughness, and aperture diffraction. We describe the formalism with which one can self-consistently compute the PSF of grazing-incidence mirrors, [...] Finally, we validate this by comparing the simulated PSF of a real Wolter-I mirror shell with the measured PSF in hard X-rays.Comment: Final version with typos correcte

Simultaneous Swift and REM monitoring of the blazar PKS0537-441 in 2005

The blazar PKS0537-441 has been observed by Swift between the end of 2004 and November 2005. The BAT monitored it recurrently for a total of 2.7 Ms, and the XRT and UVOT pointed it on seven occasions for a total of 67 ks, making it one of the AGNs best monitored by Swift. The automatic optical and infrared telescope REM has monitored simultaneously the source at all times. In January-February 2005 PKS0537-441 has been detected at its brightest in optical and X-rays: more than a factor of 2 brighter in X-rays and about a factor 60 brighter in the optical than observed in December 2004. The July 2005 observation recorded a fainter X-ray state. The simultaneous optical state, monitored by both Swift UVOT and REM, is high, and in the VRI bands it is comparable to what was recorded in early January 2005, before the outburst. In November 2005, the source subsided both in X-rays and optical to a quiescent state, having decreased by factors of ~4 and ~60 with respect to the January-February 2005 outburst, respectively. Our monitoring shows an overall well correlated optical and X-ray decay. On the shorter time scales (days or hours), there is no obvious correlation between X-ray and optical variations, but the former tend to be more pronounced, opposite to what is observed on monthly time scales. The widely different amplitude of the long term variability in optical and X-rays is very unusual and makes this observation a unique case study for blazar activity. The spectral energy distributions are interpreted in terms of the synchrotron and inverse Compton mechanisms within a jet where the plasma radiates via internal shocks and the dissipation depends on the distance of the emitting region from the central engine (abridged).Comment: 24 pages, 7 figures, 3 tables, in press in the Ap