3,485 research outputs found
LArPix: Demonstration of low-power 3D pixelated charge readout for liquid argon time projection chambers
We report the demonstration of a low-power pixelated readout system designed
for three-dimensional ionization charge detection and digital readout of liquid
argon time projection chambers (LArTPCs). Unambiguous 3D charge readout was
achieved using a custom-designed system-on-a-chip ASIC (LArPix) to uniquely
instrument each pad in a pixelated array of charge-collection pads. The LArPix
ASIC, manufactured in 180 nm bulk CMOS, provides 32 channels of
charge-sensitive amplification with self-triggered digitization and multiplexed
readout at temperatures from 80 K to 300 K. Using an 832-channel LArPix-based
readout system with 3 mm spacing between pads, we demonstrated low-noise
(500 e RMS equivalent noise charge) and very low-power (100
W/channel) ionization signal detection and readout. The readout was used
to successfully measure the three-dimensional ionization distributions of
cosmic rays passing through a LArTPC, free from the ambiguities of existing
projective techniques. The system design relies on standard printed circuit
board manufacturing techniques, enabling scalable and low-cost production of
large-area readout systems using common commercial facilities. This
demonstration overcomes a critical technical obstacle for operation of LArTPCs
in high-occupancy environments, such as the near detector site of the Deep
Underground Neutrino Experiment (DUNE).Comment: 19 pages, 10 figures, 1 ancillary animation. V3 includes minor
revisions based on referee comment
Regulating Access to Adult Content (with Privacy Preservation)
In the physical world we have well-established mechanisms for keeping children out of adult-only areas. In the virtual world this is generally replaced by self declaration. Some service providers resort to using heavy-weight identification mechanisms, judging adulthood as a side effect thereof. Collection of identification data arguably constitutes an unwarranted privacy invasion in this context, if carried out merely to perform adulthood estimation. This paper presents a mechanism that exploits the adult's more extensive exposure to public media, relying on the likelihood that they will be able to recall details if cued by a carefully chosen picture. We conducted an online study to gauge the viability of this scheme. With our prototype we were able to predict that the user was a child 99% of the time. Unfortunately the scheme also misclassified too many adults. We discuss our results and suggest directions for future research
Temperature Dependence of Exciton Diffusion in Conjugated Polymers
The temperature dependence of the exciton dynamics in a conjugated polymer is studied using time-resolved spectroscopy. Photoluminescence decays were measured in heterostructured samples containing a sharp polymer-fullerene interface, which acts as an exciton quenching wall. Using a 1D diffusion model, the exciton diffusion length and diffusion coefficient were extracted in the temperature range of 4-293 K. The exciton dynamics reveal two temperature regimes: in the range of 4-150 K, the exciton diffusion length (coefficient) of ~3 nm (~1.5 × 10-4 cm2/s) is nearly temperature independent. Increasing the temperature up to 293 K leads to a gradual growth up to 4.5 nm (~3.2 × 10-4 cm2/s). This demonstrates that exciton diffusion in conjugated polymers is governed by two processes: an initial downhill migration toward lower energy states in the inhomogenously broadened density of states, followed by temperature activated hopping. The latter process is switched off below 150 K.
The impact of realistic models of mass segregation on the event rate of extreme-mass ratio inspirals and cusp re-growth
One of the most interesting sources of gravitational waves (GWs) for LISA is
the inspiral of compact objects on to a massive black hole (MBH), commonly
referred to as an "extreme-mass ratio inspiral" (EMRI). The small object,
typically a stellar black hole (bh), emits significant amounts of GW along each
orbit in the detector bandwidth. The slowly, adiabatic inspiral of these
sources will allow us to map space-time around MBHs in detail, as well as to
test our current conception of gravitation in the strong regime. The event rate
of this kind of source has been addressed many times in the literature and the
numbers reported fluctuate by orders of magnitude. On the other hand, recent
observations of the Galactic center revealed a dearth of giant stars inside the
inner parsec relative to the numbers theoretically expected for a fully relaxed
stellar cusp. The possibility of unrelaxed nuclei (or, equivalently, with no or
only a very shallow cusp) adds substantial uncertainty to the estimates. Having
this timely question in mind, we run a significant number of direct-summation
body simulations with up to half a million particles to calibrate a much
faster orbit-averaged Fokker-Planck code. We then investigate the regime of
strong mass segregation (SMS) for models with two different stellar mass
components. We show that, under quite generic initial conditions, the time
required for the growth of a relaxed, mass segregated stellar cusp is shorter
than a Hubble time for MBHs with
(i.e. nuclei in the range of LISA). SMS has a significant impact boosting the
EMRI rates by a factor of for our fiducial models of Milky Way type
galactic nuclei.Comment: Accepted by CQG, minor changes, a bit expande
A biophysical model of prokaryotic diversity in geothermal hot springs
Recent field investigations of photosynthetic bacteria living in geothermal
hot spring environments have revealed surprisingly complex ecosystems, with an
unexpected level of genetic diversity. One case of particular interest involves
the distribution along hot spring thermal gradients of genetically distinct
bacterial strains that differ in their preferred temperatures for reproduction
and photosynthesis. In such systems, a single variable, temperature, defines
the relevant environmental variation. In spite of this, each region along the
thermal gradient exhibits multiple strains of photosynthetic bacteria adapted
to several distinct thermal optima, rather than the expected single thermal
strain adapted to the local environmental temperature. Here we analyze
microbiology data from several ecological studies to show that the thermal
distribution field data exhibit several universal features independent of
location and specific bacterial strain. These include the distribution of
optimal temperatures of different thermal strains and the functional dependence
of the net population density on temperature. Further, we present a simple
population dynamics model of these systems that is highly constrained by
biophysical data and by physical features of the environment. This model can
explain in detail the observed diversity of different strains of the
photosynthetic bacteria. It also reproduces the observed thermal population
distributions, as well as certain features of population dynamics observed in
laboratory studies of the same organisms
Accounting students' IT applicaton skills over a 10-year period
This paper reports on the changing nature of a range of information technology (IT) application skills that students declare on entering an accounting degree over the period from 1996 to 2006. Accounting educators need to be aware of the IT skills students bring with them to university because of the implications this has for learning and teaching within the discipline and the importance of both general and specific IT skills within the practice and craft of accounting. Additionally, IT skills constitute a significant element within the portfolio of employability skills that are increasingly demanded by employers and emphasized within the overall Higher Education (HE) agenda. The analysis of students' reported IT application skills on entry to university, across a range of the most relevant areas of IT use in accounting, suggest that their skills have continued to improve over time. However, there are significant differential patterns of change through the years and within cohorts. The paper addresses the generalizability of these findings and discusses the implications of these factors for accounting educators, including the importance of recognising the differences that are potentially masked by the general increase in skills; the need for further research into the changing nature, and implications, of the gender gap in entrants' IT application skills; and the low levels of entrants' spreadsheet and database skills that are a cause for concern
Storytelling as 'unorthodox' agency:negotiating the 2012 family immigration rules (United Kingdom)
This article attends to the lived experience of binational families subject to the 2012 family immigration rules (FIR). It seeks to enrich the pre-existing discussions of family migration within the European Union (EU) and the United Kingdom, focusing on the ‘micro-political’ experiences of those whose lives have been adversely affected by their introduction. It draws on the life writings of binational families, suggesting that a micro-political focus reveals an ongoing neuropolitical experience that traditional accounts of moral agency are ill-equipped to negotiate. The article suggests an unorthodox interpretation of agency premised on storytelling, while probing the tensions that emerge when this lived experience is framed in such a manner. It concludes by positing a series of questions relating to the value of a neuropolitical labelling of the subject and suggests a need to further engage with traumatic interpretations of harm at the intersection of citizenship rights and mobility rights
The Transforming Rho Family GTPase Wrch-1 Disrupts Epithelial Cell Tight Junctions and Epithelial Morphogenesis
Wrch-1, an atypical and transforming Rho GTPase, regulates cellular activities including proliferation and actin organization, but its functions and effectors remain poorly characterized. We show here that Wrch-1 distributes along the apical and basolateral membranes in MDCK cells and binds the cell polarity protein Par6 in a GTP-dependent manner. Activated Wrch-1 negatively regulates the kinetics of tight junction (TJ) assembly during epithelial cell polarization but has no detectable effect on overall cell polarity in confluent monolayers. It also causes a dramatic cytoskeletal reorganization and multilayering in cells grown in two-dimensional culture and disrupts cystogenesis of cells grown in three-dimensional (3D) culture. Similarly, short hairpin RNA-mediated knockdown of Wrch-1 perturbs cystogenesis in 3D culture, suggesting that tight regulation of Wrch-1 activity is necessary for normal epithelial morphogenesis. A weakly transforming effector domain mutant of activated Wrch-1 that inhibits Par6 binding abrogates the ability of Wrch-1 to disrupt TJ formation, actin organization, and epithelial morphogenesis. We hypothesize that Wrch-1-induced morphological and growth transformation may occur in part through Par6-mediated disruption of TJs and actin organization
Q methodology and a Delphi poll: a useful approach to researching a narrative approach to therapy
Q methodology and a Delphi poll combined qualitative and quantitative methods to explore definitions of White and Epston's (1990) narrative approach to therapy among a group of UK practitioners. A Delphi poll was used to generate statements about narrative therapy. The piloting of statements by the Delphi panel identified agreement about theoretical ideas underpinning narrative therapy and certain key practices. A wider group of practitioners ranked the statements in a Q sort and made qualitative comments about their sorting. Quantitative methods (principal components analysis) were used to extract eight accounts of narrative therapy, five of which are qualitatively analysed in this paper. Agreement and differences were identified across a range of issues, including the social construction of narratives, privileging a political stance or narrative techniques and the relationship with other therapies, specifically systemic psychotherapy. Q methodology, combined with the Delphi poll, was a unique and innovative feature of this study
Comparing families of dynamic causal models
Mathematical models of scientific data can be formally compared using Bayesian model evidence. Previous applications in the biological sciences have mainly focussed on model selection in which one first selects the model with the highest evidence and then makes inferences based on the parameters of that model. This “best model” approach is very useful but can become brittle if there are a large number of models to compare, and if different subjects use different models. To overcome this shortcoming we propose the combination of two further approaches: (i) family level inference and (ii) Bayesian model averaging within families. Family level inference removes uncertainty about aspects of model structure other than the characteristic of interest. For example: What are the inputs to the system? Is processing serial or parallel? Is it linear or nonlinear? Is it mediated by a single, crucial connection? We apply Bayesian model averaging within families to provide inferences about parameters that are independent of further assumptions about model structure. We illustrate the methods using Dynamic Causal Models of brain imaging data
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